DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SP1173 and MFSD6

DIOPT Version :9

Sequence 1:	NP_648053.1	Gene:	SP1173 / 38744	FlyBaseID:	FBgn0035710	Length:	741	Species:	Drosophila melanogaster
Sequence 2:	NP_001362915.1	Gene:	MFSD6 / 54842	HGNCID:	24711	Length:	791	Species:	Homo sapiens

Alignment Length:	717	Identity:	132/717 - (18%)
Similarity:	241/717 - (33%)	Gaps:	208/717 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 RVNKTLISLKFVVFFVITGLTALHVLHATKPLL------LGLNFSEYRTITILAPFVSILGPLIA 68
            ::|..|:..|...||..:...:|:      |||      ||::.|:...:..:..|:........
Human    63 KINNDLLISKVFYFFFYSAYGSLY------PLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFW 121

  Fly    69 GPWADRLAAKNPNTFGKTLRVLTAVFLLISAFIYAFLFAVPEVTRRGEIREPLVSFGCDETGGFL 133
            |..|||...      ||       :.||.|...:.                 |.:.|.    ||:
Human   122 GVVADRFKK------GK-------IVLLFSLLCWV-----------------LFNLGI----GFV 152

  Fly   134 FQERCGSNATCSRWDQKEGKINLTRCTYSCQNPKLYEPLYVAWLAEVPTVAPSTEQSSEFDYEDE 198
                               |....||.     ||:....:....:...|:.|:....:.|
Human   153 -------------------KPATLRCV-----PKIRPTTHPTNASHQLTILPTNSSFTSF----- 188

  Fly   199 GSTAVTESLRTRRDVESSDPADSAGVEAISGEVPLHRSIRQVKKPPTKVYVQPPHVCLTERNQNG 263
              ..::..:|.:|::..                             |::.|.......|..|.|.
Human   189 --LTISPKMREKRNLLE-----------------------------TRLNVSDTVTLPTAPNMNS 222

  Fly   264 EDVVKHCHAYTEDTTSVVMDALMGSAISQEEHYDDYEGWCQYPLEGFQCHIPEEQVNYMKDFKHY 328
            |..::   ..|.:.|:.:||..:.|:.:                      .|....:..|:....
Human   223 EPTLQ---PQTGEITNRMMDLTLNSSTA----------------------TPVSPGSVTKETTTV 262

  Fly   329 MQNDSNCKPMIECQVVNPYHEQSVLSDSECTNTTGSVQDTLVGYTTIRLIGDIFPMAALTLLNTA 393
            :...:...|  ..||:..|.:|             .|:...:....:.:||:.|..:::|:::|
Human   263 IVTTTKSLP--SDQVMLVYDQQ-------------EVEAIFLVILVVVIIGEFFSASSVTIVDT- 311

  Fly   394 IVIAVRETSEGRGEVCRQYVWGAIGYVVLFSPLDLFFFQNEPNHDAALV------------ALII 446
              :.::...:.|.....|.:||::|:.:....:.:..   :..|...|:            ..|:
Human   312 --VTLQYLGKHRDRYGLQRMWGSLGWGLAMLSVGIGI---DYTHIEVLIDGKGCKPPEYRNYQIV 371

  Fly   447 FIVSFVLGAVVLLCATQMPLSPPEWWWHTKTGMLV-VPM------SAIRRYTPEI---------- 494
            |||..||..:.|:.|||.......:......|..| :|.      :.....||..
Human   372 FIVFGVLMTMALIVATQFRFRYNHFKNDDSKGKEVEIPQVERNNSTESSEETPTTTSHSQAFNFW 436

  Fly   495 -LVLTLVSILFGTF----------WSSIHSYLWWTFTDVD------AVCYSGL--ILILVLFFNV 540
             |:..|.|:.:|:.          :..:.::|:|...|::      .|| |.|  :..|..:|..
Human   437 DLIKLLCSVQYGSVLFVAWFMGFGYGFVFTFLYWHLEDLNGTTTLFGVC-SVLSHVSELTAYFFS 500

  Fly   541 DKFIEYCGHSNIFIGGLAIFVIRFTALSDAQTKWLTVIMETIEPAVIGLIWITIILYMRHAMPRK 605
            .|.||..||..:...|||....|:..:|..:..|..:.||.::......||...|.|:..|:|.:
Human   501 HKLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPE 565

  Fly   606 LTATGQAIAVLAFFGLGKGFGALIGLARDERDPKLEFWSCTYQWLAI-VACVVALIYFGIYNLIL 669
            |..:.|.|......|||:|.||:||      ...:.::.....:..| :||:|.|:.|.:...:.
Human   566 LRTSAQGILQGLHLGLGRGCGAMIG------GVLVNYFGAAATFRGIGMACLVILLLFALIQWLA 624

  Fly   670 AP 671
            .|
Human   625 VP 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SP1173	NP_648053.1	MFS	15..88	CDD:304372	18/78 (23%)
SP1173	NP_648053.1	Chromate_transp	<552..632	CDD:302665	25/79 (32%)
MFSD6	NP_001362915.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..47
		MFS_MFSD6	70..622	CDD:340893	129/704 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	407..427		3/19 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	662..687
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	723..791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3762
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810