DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SP1173 and CG31663

DIOPT Version :9

Sequence 1:	NP_648053.1	Gene:	SP1173 / 38744	FlyBaseID:	FBgn0035710	Length:	741	Species:	Drosophila melanogaster
Sequence 2:	NP_001259884.1	Gene:	CG31663 / 33363	FlyBaseID:	FBgn0051663	Length:	966	Species:	Drosophila melanogaster

Alignment Length:	779	Identity:	167/779 - (21%)
Similarity:	290/779 - (37%)	Gaps:	190/779 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 VNKTLISLKFVVFFVITGLTALHVLHATKPL-LLGLNFSEYRTITILAPFVSILGPLIAGPWADR 74
            :|..||.|| :..||:.|.|:..:.:.|..: .:||...|...|.:..||.:.|.|.|.|...|:
  Fly    33 INPNLIMLK-ITLFVMYGATSSLLPYLTIHMQSIGLTVEEIAIIYLALPFTTFLSPPITGFLVDK 96

  Fly    75 LAAKNPNTFGKTLRVLTAVFLLISAFIYAFLFAVPEVTRRGEIREPLVSFGCDETGGFLFQERCG 139
                    |||...|:....||.:.|.::.|| :|:....|.:....|....|.....::...|.
  Fly    97 --------FGKYKPVVVMSLLLNAIFHHSLLF-IPQQEIPGVVPSAFVLRHPDSGDIEVWWSPCP 152

  Fly   140 SNATCSRWDQKEGKINLTRCTYSC-----QNPKLY--EPLY----------------VAWLAEVP 181
            |. .|.  ::.|.::.:.:|...|     .||:||  .|.|                .|..|...
  Fly   153 SR-ECP--EEPELELAVHQCVDYCLMQEQVNPQLYTNTPAYDVRPAATTSTTQRSQLTATTARTT 214

  Fly   182 TVAPSTEQSSEFDYEDEGSTAVTESLRTRRDVESSDPADSAGVEAISGEVPLHRSIRQVKKPPTK 246
            |:.||:|.||        |.|.|.|..|       .||.|  :.|:.......| .::|....:.
  Fly   215 TMEPSSESSS--------SPAPTTSTTT-------SPASS--LPALFATQTRSR-YQEVLNMSST 261

  Fly   247 VYVQPPHVCLTERNQNGEDVVKHCHAYTEDTTSVVMDALMGSAISQEE-------HYDDYEGWCQ 304
            ::  ||...|.:..:.|   |:...:.:.:.:::.|..|..:..||::       |.|:.:  ..
  Fly   262 MF--PPMSQLKDALEEG---VEPGQSSSAELSAMSMQGLNLTNSSQKKLLWSSWVHSDNDD--AT 319

  Fly   305 YPLEGFQCH----IPEEQV-------------NYMKDFKH-YMQN-----------DSNCKPM-- 338
            |.:  .|.|    .|.||:             :.::.|.| |:..           |..|..:
  Fly   320 YFM--LQMHPDLADPTEQLGMEIEQDANETVTDILQRFGHDYLVRGNINLTDMDDLDLRCGGLVR 382

  Fly   339 -----------IECQVVNPYHEQSVLSDSECTNTTGSVQ---------DTLV--GYTTIRLIGDI 381
                       :||.:            ..||.|..:.:         |.::  .|..:|.:...
  Fly   383 RTNMTNIASGAVECMM------------QRCTFTLNAPEICPPDYKETDEIIFWVYFLLRFLATT 435

  Fly   382 FPMAALTLLNTAIVIAVRETSEGRGEVCRQYVWGAIGYVVLFSPLDLFFFQNEPNHDAALVALII 446
            ...|.:|:::.   ||:....:..|:..|:.::.:|| :.:|||:.....    ::.:..:....
  Fly   436 MLSAGVTIMDP---IALTMIEKYGGDFGRERLFSSIG-MAIFSPITGIMI----DYSSRGLGYTD 492

  Fly   447 FIVSFVLGAVVLLCAT----QMPLS---PPEWWWHTKTGMLVVPMSAIRRYTPEILVLTLVSILF 504
            :..:|....|:|:.:|    .|||.   |.:..:.....:|.:|.           |:..:..||
  Fly   493 YSAAFYTYDVLLVISTMSVLMMPLGEKLPADNVFRDLWNLLKMPH-----------VIAFICFLF 546

  Fly   505 --GTFWSSIHSYLWWTFTDVDAVCY-------SGLILILVLFFNVDKFIEYCGHSNIFIGGLAIF 560
              |.||..|.|:|:....::.|..|       .|.:..:...:..:|.....||.|:.|......
  Fly   547 VLGNFWGFIESFLFLYLKELGAPNYLLGITITVGTVSSIPFLYGAEKITRIFGHVNLIIIAFFSH 611

  Fly   561 VIRFTALSDAQTKWLTVIMETIEPAVIGLIWITIILYMRHAMPRKLTATGQAIAVLAFFGLGKGF 625
            ..|....|..:|.|.....|.:|.....|:|:....|.....|:.|.||...:..:|.|.||:|.
  Fly   612 AGRLVGYSFIETAWWCFPFEAMESLSCHLMWVAAATYCSILAPKSLLATLIGVLGMAHFSLGRGS 676

  Fly   626 GA-----LIGL--ARDERDPKLEFWSCTYQWLAIVACVVALIYFGIYNLILAPRCTAKPQHSEE 682
            |:     |||.  .||           .::::.::| ||..|.:|:.:||...:.....:.|||
  Fly   677 GSFTGGLLIGQFGTRD-----------AFRYMGLLA-VVGGIAYGLLHLIWLRKFDHTTEESEE 728

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SP1173	NP_648053.1	MFS	15..88	CDD:304372	23/73 (32%)
SP1173	NP_648053.1	Chromate_transp	<552..632	CDD:302665	23/86 (27%)
CG31663	NP_001259884.1	MFS_1_like	36..111	CDD:289593	25/83 (30%)
		MFS	<423..711	CDD:119392	69/318 (22%)
		MFS_1	<423..678	CDD:284993	58/273 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467107
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3762
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR16172
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840