DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SP1173 and Mfsd6

DIOPT Version :9

Sequence 1:	NP_648053.1	Gene:	SP1173 / 38744	FlyBaseID:	FBgn0035710	Length:	741	Species:	Drosophila melanogaster
Sequence 2:	NP_001100381.1	Gene:	Mfsd6 / 301388	RGDID:	1562317	Length:	794	Species:	Rattus norvegicus

Alignment Length:	728	Identity:	135/728 - (18%)
Similarity:	245/728 - (33%)	Gaps:	228/728 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 RVNKTLISLKFVVFFVITGLTALHVLHATKPLL------LGLNFSEYRTITILAPFVSILGPLIA 68
            ::|..|:..|...||..:...:|:      |||      ||::.|:...:..:..|:........
  Rat    64 KINNDLLISKVFYFFFYSAYGSLY------PLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFW 122

  Fly    69 GPWADRLAAKNPNTFGKTLRVLTAVFLLISAFIYAFLFAVPEVTRRGEIREPLVSFGCDETGGFL 133
            |..|||...      ||       :.||.|...:.                 |.:.|.    ||:
  Rat   123 GVVADRFKK------GK-------IVLLFSLLCWV-----------------LFNLGI----GFV 153

  Fly   134 FQERCGSNATCSRWDQKEGKINLTRCTYSCQNPKLYEPLYVAWLAEVPTVAPSTEQSSEFDYEDE 198
                               |....||.     ||:....:...::...|:.|....:..|
  Rat   154 -------------------KPATLRCI-----PKIPPTAHPTNVSHPVTILPMNSSTVAF----- 189

  Fly   199 GSTAVTESLRTRRDVESSDPADSAGVEAISGEVPLHRSIRQVKKPPTKVYVQPPHVCLTERNQNG 263
             .|...:||..|..:.|:...:.:.::.:|..:.|  :.....:|.|:....  ||  |:...|.
  Rat   190 -FTTPPKSLEKRSLLFSATEPNISNIDLLSTALTL--TTEPTLRPQTEGITH--HV--TDLILNT 247

  Fly   264 EDV-VKHCHAYTEDTTSVVMDALMGSAISQEEHYDDYEGWCQYPLEGFQCHIPEEQVNYMKDFKH 327
            ..| :......|.:||..|:.....                          :|.:||..:
  Rat   248 STVTLPPTGNVTRETTIAVVTTTKS--------------------------LPSDQVTLV----- 281

  Fly   328 YMQNDSNCKPMIECQVVNPYHEQSVLSDSECTNTTGSVQDTLVGYTTIRLIGDIFPMAALTLLNT 392
                               |.:|             .|:...:....:.:||:.|..:::|:::|
  Rat   282 -------------------YDQQ-------------EVEAIFLVILVVVIIGEFFSASSVTIVDT 314

  Fly   393 AIVIAVRETSEGRGEVCRQYVWGAIGYVVL---------FSPLDLFF---------FQNEPNHDA 439
               :.::...:.|.....|.:||::|:.:.         ::.:|:..         ::|..
  Rat   315 ---VTLQYLGKHRDRYGLQRMWGSLGWGLAMLSVGIGIDYTHIDVLIDGKGCKPPEYRNYQ---- 372

  Fly   440 ALVALIIFIVSFVLGAVVLLCATQMPLSPPEWWWH-----TKTGMLVVPM------SAIRRYTPE 493
                 |:|||..||..:.|:.|||....    :.|     .|...:.:|.      :.....||.
  Rat   373 -----IVFIVFGVLMTMALIVATQFRFR----YNHFNNSDGKGKEMEIPQVERDNSTESSEETPT 428

  Fly   494 I-----------LVLTLVSILFGTF----------WSSIHSYLWWTFTDVD------AVCYSGL- 530
            .           |:..|.|:.:|:.          :..:.::|:|...|::      .|| |.|
  Rat   429 AATHSQAFNFWDLIKLLCSVQYGSVLFVAWFMGFGYGFVFTFLYWHLEDLNGTTTLFGVC-SVLS 492

  Fly   531 -ILILVLFFNVDKFIEYCGHSNIFIGGLAIFVIRFTALSDAQTKWLTVIMETIEPAVIGLIWITI 594
             :..|..:|...|.||..||..:...|||....|:..:|..:..|..:.||.::......||...
  Rat   493 HVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGVTHAAIWAAC 557

  Fly   595 ILYMRHAMPRKLTATGQAIAVLAFFGLGKGFGALIGLARDERDPKLEFWSCTYQWLAI-VACVVA 658
            |.|:..|:|.:|..:.|.|......|||:|.||:||      ...:.::.....:..| :||:|.
  Rat   558 ISYLSAAVPPELRTSAQGILQGLHLGLGRGCGAMIG------GVLVNYFGAAATFRGIGMACLVI 616

  Fly   659 LIYFGIYNLILAP 671
            |:.|.:...:..|
  Rat   617 LLLFALIQWLAVP 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SP1173	NP_648053.1	MFS	15..88	CDD:304372	18/78 (23%)
SP1173	NP_648053.1	Chromate_transp	<552..632	CDD:302665	25/79 (32%)
Mfsd6	NP_001100381.1	MFS_1_like	68..143	CDD:289593	21/93 (23%)
		MFS_1	<77..169	CDD:284993	28/155 (18%)
		TMIE	366..>395	CDD:292657	11/37 (30%)
		MFS_1	453..>651	CDD:284993	46/184 (25%)
		MFS	453..>623	CDD:119392	45/176 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3762
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810