DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SP1173 and mfsd6a

DIOPT Version :9

Sequence 1:	NP_648053.1	Gene:	SP1173 / 38744	FlyBaseID:	FBgn0035710	Length:	741	Species:	Drosophila melanogaster
Sequence 2:	NP_001076525.1	Gene:	mfsd6a / 100034426	ZFINID:	ZDB-GENE-050208-335	Length:	793	Species:	Danio rerio

Alignment Length:	750	Identity:	141/750 - (18%)
Similarity:	232/750 - (30%)	Gaps:	284/750 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 RVNKTLISLKFVVFFVITGLTALHVLHATKPLLLGLNFSEYRTITILAPFVSILGPLIAGPWADR 74
            |||:.|:..|....|......:||.|.|.....||:|.::...:..:..|:........|..|||
Zfish    65 RVNRHLLVSKVFYLFFYAAYGSLHPLLALYYKQLGMNPTQSGLLVGIRYFIEFCSAPFWGIVADR 129

  Fly    75 LAAKNPNTFGKTLRVLTAV-FLLISAFIYAFLFAVPEVTRRGEIREPLVSFGCDETGGFLFQERC 138
            ...      ||.:.:.:.: ::|.:|.|             |.::.|:::
Zfish   130 YRK------GKAVLLFSMLCWILFNAGI-------------GIVKPPIMA--------------- 160

  Fly   139 GSNATCSRWDQKEGKINLTRCTYSCQNPKLYEPLYVAWLAEVPTVAPSTEQSSEFDYEDEGSTAV 203
                 |     ||..|..|                    .:||||.|:....:.|.     :|:.
Zfish   161 -----C-----KEETIPTT--------------------TKVPTVHPTPSNETFFP-----NTSS 190

  Fly   204 TESLRTRRDVESSDP---ADSAGVEAISGEVPLHRSIRQVKKPPTKVYVQPPH--VCLTERNQNG 263
            |..:|.|||:....|   ..|:|..  ||.:..||    :|:.....:...|.  ...|:.||
Zfish   191 TSQMRRRRDLIGQYPWRTILSSGQS--SGYISEHR----IKRDSNLSFTPAPEELANTTQTNQ-- 247

  Fly   264 EDVVKHCHAYTEDTTSVVMDALMGSAISQEEHYDDYEGWCQYPLEGFQCHIPEEQVNYMKDFKHY 328
                      |..||..
Zfish   248 ----------TSTTTQP------------------------------------------------ 254

  Fly   329 MQNDSNCKPMIECQVVNPYHEQSVLSDSECTNTTGSVQDTLVGYTT------------------- 374
                   ||........|          ..||||.|  .|....||
Zfish   255 -------KPSTSISTSTP----------SSTNTTSS--STTKSTTTNPNLPPPEYNMDQVNAIFL 300

  Fly   375 ----IRLIGDIFPMAALTLLNTAIVIAVRETSEGRGEVCRQYVWGAIGYVVLFSPLDLF------ 429
                :.:||:.|...|:|:::|   :.:......|.....|.:||::|:.:....:.::
Zfish   301 LILLVIIIGEFFSAPAITIVDT---VTLHYLGPHRDRYGLQRMWGSLGWGLAMLCIGIWIDHTST 362

  Fly   430 ---------FFQNEPNHDAALVALIIFIVSFVLGAVVLLCATQ---------------------- 463
                     ..:|..|:.      |.|||..||..:.|:.|||
Zfish   363 NLIIGNMECIMKNYKNYH------IAFIVFGVLMVIALIVATQFKFDVQHHDTNEGQEVGNQQEN 421

  Fly   464 -MPLSPP--------------EW-WWHTKTGMLVVPMSAIRRYTPEILVLTLVSILFGTFWSSIH 512
             .|...|              |: :|.....:..|..|.:          ..|:...|..:..:.
Zfish   422 VQPRGSPGTRSTDTPTIVQAEEFHFWDLMRLLCGVQYSTV----------LFVAWFMGFGYGFVF 476

  Fly   513 SYLWWTFTDVD------AVCYSGL--ILILVLFFNVDKFIEYCGHSNIFIGGLAIFVIRFTALSD 569
            ::|:|...|:.      .:| |.|  :..|..:|...||||..||..:...|||....|:..:|.
Zfish   477 TFLYWHLQDLTGTTTLFGIC-SVLSHVSELAAYFTSHKFIELVGHIRVLYIGLACNTARYLYISY 540

  Fly   570 AQTKWLTVIMETIEPAVIGLIWITIILYMRHAMPRKLTATGQAIAVLAFFGLGKGFGALI----- 629
            .:..|..:.||.::......:|...|.|:..|:|..|..:.|.|......|||:|.||::
Zfish   541 LENAWTVLPMEVLQGITHASVWAACISYLSAAVPPPLRTSAQGILQGLHLGLGRGCGAMVGGIFV 605

  Fly   630 ---GLARDERDPKLEFWSCTYQWLAIVACVVALIY 661
               |:|.            |::.:.:.:.|:.||:
Zfish   606 NYFGVAE------------TFRGIGMASLVILLIF 628

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SP1173	NP_648053.1	MFS	15..88	CDD:304372	17/72 (24%)
SP1173	NP_648053.1	Chromate_transp	<552..632	CDD:302665	23/87 (26%)
mfsd6a	NP_001076525.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..53
		MFS_1_like	69..144	CDD:289593	17/80 (21%)
		MFS_1	77..>154	CDD:284993	19/95 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	170..195		8/29 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	239..288		17/127 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	412..434		2/21 (10%)
		MFS_1	461..>659	CDD:284993	44/190 (23%)
		MFS	461..>632	CDD:119392	44/190 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	674..699
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	734..793
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3762
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810