Protein Alignment eIF4E4 and EIF4E2

DIOPT Version :10

• Sequence 1: NP_648052.1
• Gene: eIF4E4 / 38743
• FlyBaseID: FBgn0035709
• Length: 229
• Species: Drosophila melanogaster
• Sequence 2: NP_004837.1
• Gene: EIF4E2 / 9470
• HGNCID: 3293
• Length: 245
• Species: Homo sapiens
• Alignment Length: 230
• Identity: 77/230 - (33%)
• Similarity: 125/230 - (54%)
• Gaps: 26/230 - (11%)

  Fly    12 MDNGTETLADSPS---SSSEDLKTLSDMDIRKPVTE------------IVDLRLKHPLENTWTLW 61
            |:|..:.|.|..|   ..:|:..|..|.:  |..||            :|....:|||:..:|.|
Human     1 MNNKFDALKDDDSGDHDQNEENSTQKDGE--KEKTERDKNQSSSKRKAVVPGPAEHPLQYNYTFW 63

  Fly    62 YLEN-----DRSKNWEDMQNEITSFDMVEDFWSLYNHIKQPSEIRVGSDYSLFKKGIQPMWEDDA 121
            |...     ..|:::|....:|.:|..||.||..|:|:.:|.::...||:.|||:||:|||||||
Human    64 YSRRTPGRPTSSQSYEQNIKQIGTFASVEQFWRFYSHMVRPGDLTGHSDFHLFKEGIKPMWEDDA 128

  Fly   122 NKFGGRWVINMGRGSKAELDKLWLDVLLILIGEAFENTEEVCGAVINLRGKSNKISIWTANGHNE 186
            ||.||:|:|.:.:|..:   :.|.:::|.::||.|...||:||||:::|.:.:.||||.....::
Human   129 NKNGGKWIIRLRKGLAS---RCWENLILAMLGEQFMVGEEICGAVVSVRFQEDIISIWNKTASDQ 190

  Fly   187 LAVMEIGLKLRDLLVLPPHQ-LQYQLHKDTMCKQG 220
            .....|...||.:|.|||:. ::|:.|.|::...|
Human   191 ATTARIRDTLRRVLNLPPNTIMEYKTHTDSIKMPG 225

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF4E4	NP_648052.1	IF4E	53..209	CDD:460281	60/161 (37%)
EIF4E2	NP_004837.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..52		12/52 (23%)
		EIF4EBP1/2/3 binding. /evidence=ECO:0000269|PubMed:17368478	54..57		2/2 (100%)
		IF4E	55..214	CDD:460281	60/161 (37%)
		EIF4EBP1/2/3 binding. /evidence=ECO:0000269|PubMed:17368478	95..99		1/3 (33%)
		EIF4EBP1/2/3 binding. /evidence=ECO:0000269|PubMed:17368478	150..157		1/6 (17%)