DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF4E4 and eif4e1c

DIOPT Version :9

Sequence 1:	NP_648052.1	Gene:	eIF4E4 / 38743	FlyBaseID:	FBgn0035709	Length:	229	Species:	Drosophila melanogaster
Sequence 2:	XP_005156696.1	Gene:	eif4e1c / 550549	ZFINID:	ZDB-GENE-050417-398	Length:	230	Species:	Danio rerio

Alignment Length:	221	Identity:	105/221 - (47%)
Similarity:	142/221 - (64%)	Gaps:	21/221 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 GTET---LADSPSSSSEDLKTLSDMDIRKPVTEIVDLRLKHPLENTWTLWYLENDRSKNWEDMQN 76
            ||||   .:|||::               .||...:..:||||:|.|.|||.:||:||:|.:...
Zfish    25 GTETEEVRSDSPTA---------------VVTTSPEQYIKHPLQNRWALWYFKNDKSKSWTENLR 74

  Fly    77 EITSFDMVEDFWSLYNHIKQPSEIRVGSDYSLFKKGIQPMWEDDANKFGGRWVINMGRGSK-AEL 140
            .|:.||.|||||:|||||:|||::..|.||.|||.||:||||||.||.||||::.:.:..: .:|
Zfish    75 LISKFDTVEDFWALYNHIQQPSKLGFGCDYCLFKDGIKPMWEDDRNKLGGRWLMTLSKQQRHNDL 139

  Fly   141 DKLWLDVLLILIGEAF-ENTEEVCGAVINLRGKSNKISIWTANGHNELAVMEIGLKLRDLLVLPP 204
            |:.|::.||.||||:| |.:|:|||||:|:|.|.:||:|||.|..|..|:|.||.:.::.|.||.
Zfish   140 DRYWMETLLCLIGESFDEASEDVCGAVVNVRPKGDKIAIWTGNCQNRDAIMTIGQQYKERLSLPS 204

  Fly   205 HQL-QYQLHKDTMCKQGSVIKAVYCV 229
            ..| .||.|.||..|.||..|.:|.|
Zfish   205 KTLIGYQSHDDTSSKSGSTTKNMYSV 230

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF4E4	NP_648052.1	IF4E	56..209	CDD:279921	81/155 (52%)
eif4e1c	XP_005156696.1	IF4E	54..210	CDD:279921	81/155 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573587
Domainoid	1	1.000	193	1.000	Domainoid score	I3137
eggNOG	1	0.900	-	-		E1_COG5053
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	216	1.000	Inparanoid score	I3585
OMA	1	1.010	-	-		QHG54586
OrthoDB	1	1.010	-	-		D1394271at2759
OrthoFinder	1	1.000	-	-		FOG0000666
OrthoInspector	1	1.000	-	-		mtm6577
orthoMCL	1	0.900	-	-		OOG6_100627
Panther	1	1.100	-	-	O	PTHR11960
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R595
SonicParanoid	1	1.000	-	-		X406
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800