DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF4E4 and eif4e2

DIOPT Version :9

Sequence 1:	NP_648052.1	Gene:	eIF4E4 / 38743	FlyBaseID:	FBgn0035709	Length:	229	Species:	Drosophila melanogaster
Sequence 2:	NP_001014815.2	Gene:	eif4e2 / 541523	ZFINID:	ZDB-GENE-050327-59	Length:	236	Species:	Danio rerio

Alignment Length:	223	Identity:	76/223 - (34%)
Similarity:	126/223 - (56%)	Gaps:	21/223 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 MDNGTETLADSPS-------SSSED-LKTLSDMDIRKPVT----EIVDLRLKHPLENTWTLWYLE 64
            |:|..:.|.|..|       ||.:| .|..:|.:.::..|    .:|....:|||:..:|.||..
Zfish     1 MNNKFDALKDDDSGDHDQDNSSPKDGEKEKNDEEDKEANTTKRKAVVPGAGEHPLQYNYTFWYSR 65

  Fly    65 ND-----RSKNWEDMQNEITSFDMVEDFWSLYNHIKQPSEIRVGSDYSLFKKGIQPMWEDDANKF 124
            ..     .::::|....:|.||..||.||..|:|:.:|.::...||:.|||:||:|||||||||.
Zfish    66 RTPGRPASTQSYEQNIKQIGSFASVEQFWRFYSHMIRPGDLTGHSDFHLFKEGIKPMWEDDANKS 130

  Fly   125 GGRWVINMGRGSKAELDKLWLDVLLILIGEAFENTEEVCGAVINLRGKSNKISIWTANGHNELAV 189
            ||:|:|.:.:|..:   :.|.:::|.::||.|...||:||||:::|.:.:.||||.....::...
Zfish   131 GGKWIIRLRKGLAS---RCWENLILAMLGEQFMVGEEICGAVVSVRFQEDIISIWNKTASDQATT 192

  Fly   190 MEIGLKLRDLLVLPPHQ-LQYQLHKDTM 216
            ..|...||.:|.|||:. ::|:.|.|::
Zfish   193 ARIRDTLRRVLNLPPNTIMEYKTHTDSI 220

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF4E4	NP_648052.1	IF4E	56..209	CDD:279921	58/158 (37%)
eif4e2	NP_001014815.2	IF4E	54..212	CDD:307672	60/160 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573581
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5053
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54586
OrthoDB	1	1.010	-	-		D1394271at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.760