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Protein Alignment eIF4E4 and EIF4E3

DIOPT Version :9

Sequence 1:	NP_648052.1	Gene:	eIF4E4 / 38743	FlyBaseID:	FBgn0035709	Length:	229	Species:	Drosophila melanogaster
Sequence 2:	NP_001128123.1	Gene:	EIF4E3 / 317649	HGNCID:	31837	Length:	224	Species:	Homo sapiens

Alignment Length:	184	Identity:	50/184 - (27%)
Similarity:	90/184 - (48%)	Gaps:	28/184 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 PLENTWTLWYLENDRS------KNWEDMQNEITSFDMVEDFWSLYNHIKQPSEIRVGSDYSLFKK 111
            ||.::||.|.   |||      ........:|.:...|:.|||:||:|...:.:.:...|.|.:.
Human    48 PLHSSWTFWL---DRSLPGATAAECASNLKKIYTVQTVQIFWSVYNNIPPVTSLPLRCSYHLMRG 109

  Fly   112 GIQPMWEDDANKFGGRWVINMGRGSKAELDKLWLDVLLILIGEAFEN----TEEVCGAVINLRGK 172
            ..:|:||:::|..||.|.:.:.:.|.:   .:|.::||..|||.|.:    .:||.|..:::|.:
Human   110 ERRPLWEEESNAKGGVWKMKVPKDSTS---TVWKELLLATIGEQFTDCAAADDEVIGVSVSVRDR 171

  Fly   173 SNKISIWTANGH--NELAVMEIGLKLRDLLVLPPH----QLQYQLHKDTMCKQG 220
            .:.:.:|..|..  .|..|:|   |:.:||   ||    .:.|:.|::....:|
Human   172 EDVVQVWNVNASLVGEATVLE---KIYELL---PHITFKAVFYKPHEEHHAFEG 219

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.