Protein Alignment eIF4E4 and EIF4E1B

DIOPT Version :10

• Sequence 1: NP_648052.1
• Gene: eIF4E4 / 38743
• FlyBaseID: FBgn0035709
• Length: 229
• Species: Drosophila melanogaster
• Sequence 2: NP_001092878.1
• Gene: EIF4E1B / 253314
• HGNCID: 33179
• Length: 242
• Species: Homo sapiens
• Alignment Length: 218
• Identity: 95/218 - (43%)
• Similarity: 141/218 - (64%)
• Gaps: 8/218 - (3%)

  Fly    16 TETLADSPSSSSEDLKTLSDMDIRKPVTEIVDLRLK-HPLENTWTLWYLENDRSKNWEDMQNEIT 79
            |.|...||:|.    :||..:..:......::::|: |||:|.|.||:.:||||:.|:|..:.:|
Human    29 TPTGEKSPNSP----RTLLSLRGKARTGGPMEVKLELHPLQNRWALWFFKNDRSRAWQDNLHLVT 89

  Fly    80 SFDMVEDFWSLYNHIKQPSEIRVGSDYSLFKKGIQPMWEDDANKFGGRWVINMGRGSK-AELDKL 143
            ..|.|||||:||:||:..|::..|.||:|||.||||||||..||.||||::::.:..: .|||:|
Human    90 KVDTVEDFWALYSHIQLASKLSSGCDYALFKDGIQPMWEDSRNKRGGRWLVSLAKQQRHIELDRL 154

  Fly   144 WLDVLLILIGEAF-ENTEEVCGAVINLRGKSNKISIWTANGHNELAVMEIGLKLRDLLVLPPHQ- 206
            ||:.||.||||:| |::.||||||:|:|.|.:||::||....|:..|:.:|...::.|.|.|..
Human   155 WLETLLCLIGESFEEHSREVCGAVVNIRTKGDKIAVWTREAENQAGVLHVGRVYKERLGLSPKTI 219

  Fly   207 LQYQLHKDTMCKQGSVIKAVYCV 229
            :.||.|.||..|..|:.|..:.|
Human   220 IGYQAHADTATKSNSLAKNKFVV 242

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF4E4	NP_648052.1	IF4E	53..209	CDD:460281	77/158 (49%)
EIF4E1B	NP_001092878.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..42		5/16 (31%)
		EIF4EBP1/2/3 binding. /evidence=ECO:0000250	62..65		2/2 (100%)
		IF4E	63..222	CDD:460281	77/158 (49%)
		EIF4EBP1/2/3 binding. /evidence=ECO:0000250	98..102		2/3 (67%)
		EIF4EBP1/2/3 binding. /evidence=ECO:0000250	157..164		3/6 (50%)