DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF4E4 and Eif4e1b

DIOPT Version :9

Sequence 1:	NP_648052.1	Gene:	eIF4E4 / 38743	FlyBaseID:	FBgn0035709	Length:	229	Species:	Drosophila melanogaster
Sequence 2:	NP_001273108.1	Gene:	Eif4e1b / 218268	MGIID:	2685119	Length:	250	Species:	Mus musculus

Alignment Length:	222	Identity:	88/222 - (39%)
Similarity:	135/222 - (60%)	Gaps:	18/222 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 ETLADSPSSSSED-------------LKTLSDMDIRKPVTEIVDLRLKHPLENTWTLWYLENDRS 68
            |.:.:.||.::.:             |||......|:...|:  |...|||:..|.||:.:||||
Mouse    25 EVVKEKPSEATAEGVQAGEAKDLPGSLKTQRRKAHREHPPEV--LSKLHPLQYRWVLWFFKNDRS 87

  Fly    69 KNWEDMQNEITSFDMVEDFWSLYNHIKQPSEIRVGSDYSLFKKGIQPMWEDDANKFGGRWVINMG 133
            :.|:|....:|.|:.|||||::|:|||..|::..|.||:|||:||.|||||:.||.||||::::.
Mouse    88 RAWQDNLQLVTKFNTVEDFWAVYSHIKLASKLSSGCDYALFKEGILPMWEDNRNKQGGRWLLSID 152

  Fly   134 RGSK-AELDKLWLDVLLILIGEAFEN-TEEVCGAVINLRGKSNKISIWTANGHNELAVMEIGLKL 196
            :..: .|||:|||:.||.|:|..||. :.||||||:|:|.|.:||::||:...::..||:||...
Mouse   153 KQLRHFELDRLWLETLLCLVGNCFEEYSREVCGAVVNIRTKRDKIALWTSEAEDKAGVMQIGQIY 217

  Fly   197 RDLLVLPPHQ-LQYQLHKDTMCKQGSV 222
            ::.|.:.... :.||.|.||..|..::
Mouse   218 KERLGISTKTIIGYQAHADTAAKSNNL 244

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF4E4	NP_648052.1	IF4E	56..209	CDD:279921	70/155 (45%)
Eif4e1b	NP_001273108.1	IF4E	75..231	CDD:279921	70/155 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830792
Domainoid	1	1.000	186	1.000	Domainoid score	I3337
eggNOG	1	0.900	-	-		E1_COG5053
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	215	1.000	Inparanoid score	I3600
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54586
OrthoDB	1	1.010	-	-		D1394271at2759
OrthoFinder	1	1.000	-	-		FOG0000666
OrthoInspector	1	1.000	-	-		mtm8694
orthoMCL	1	0.900	-	-		OOG6_100627
Panther	1	1.100	-	-	O	PTHR11960
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R595
SonicParanoid	1	1.000	-	-		X406
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.800