Protein Alignment eIF4E4 and EIF4E

DIOPT Version :10

• Sequence 1: NP_648052.1
• Gene: eIF4E4 / 38743
• FlyBaseID: FBgn0035709
• Length: 229
• Species: Drosophila melanogaster
• Sequence 2: NP_001124151.1
• Gene: EIF4E / 1977
• HGNCID: 3287
• Length: 248
• Species: Homo sapiens
• Alignment Length: 247
• Identity: 98/247 - (39%)
• Similarity: 139/247 - (56%)
• Gaps: 39/247 - (15%)

  Fly    17 ETLADSPSSSSEDLKTLSDMDIRKPVTEIVDLRLKHPLENTWTLWYLENDRSKNWEDMQNEITSF 81
            ||.......::|:.||.|:.::..|     :..:||||:|.|.||:.:||:||.|:.....|:.|
Human     7 ETTPTPNPPTTEEEKTESNQEVANP-----EHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKF 66

  Fly    82 DMVEDFWSLYNHIKQPSEIRVGSDYSLFKKGIQPMWEDDANKFGGRWVINMGRGS-KAELDKLWL 145
            |.|||||:|||||:..|.:..|.||||||.||:|||||:.||.||||:|.:.:.. :::||:.||
Human    67 DTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWL 131

  Fly   146 DV-------------------------------LLILIGEAFEN-TEEVCGAVINLRGKSNKISI 178
            :.                               ||.||||:|:: :::|||||:|:|.|.:||:|
Human   132 ETRWDLAMLPRLVSNFWPQVILPLQPPKVLELQLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAI 196

  Fly   179 WTANGHNELAVMEIGLKLRDLLVLPPH-QLQYQLHKDTMCKQGSVIKAVYCV 229
            ||....|..||..||...::.|.|||. .:.||.|.||..|.||..|..:.|
Human   197 WTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 248

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF4E4	NP_648052.1	IF4E	53..209	CDD:460281	79/189 (42%)
EIF4E	NP_001124151.1	IF4E	38..228	CDD:460281	79/189 (42%)