DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF4E4 and ife-3

DIOPT Version :9

Sequence 1:	NP_648052.1	Gene:	eIF4E4 / 38743	FlyBaseID:	FBgn0035709	Length:	229	Species:	Drosophila melanogaster
Sequence 2:	NP_503123.1	Gene:	ife-3 / 178536	WormBaseID:	WBGene00002061	Length:	251	Species:	Caenorhabditis elegans

Alignment Length:	221	Identity:	88/221 - (39%)
Similarity:	133/221 - (60%)	Gaps:	15/221 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 TETLADSPSSSSEDLKTLSDMDIRKPVTEIVDLRLKHPLENTWTLWYLENDRSKNWEDMQNEITS 80
            |....:...|:|.|:.. ||..:..      :|..:|||:|.|.||||:.||:|.|||....::.
Worm     3 TSVAENKALSASGDVNA-SDASVPP------ELLTRHPLQNRWALWYLKADRNKEWEDCLKMVSL 60

  Fly    81 FDMVEDFWSLYNHIKQPSEIRVGSDYSLFKKGIQPMWEDDANKFGGRWVINMGRGSKAE-----L 140
            ||.|||||||||||:....:..||||.|||:||:|||||..|..||||::.:.: .|.:     |
Worm    61 FDTVEDFWSLYNHIQSAGGLNWGSDYYLFKEGIKPMWEDVNNVQGGRWLVVVDK-QKLQRRTQLL 124

  Fly   141 DKLWLDVLLILIGEAF-ENTEEVCGAVINLRGKSNKISIWTANGHNELAVMEIGLKLRDLLVLPP 204
            |..||::|:.::||.| |..:.:||||:|:|.|.:|:|:||.:...:...:.||..|:..|.:|.
Worm   125 DHYWLELLMAIVGEQFDEYGDYICGAVVNVRQKGDKVSLWTRDATRDDVNLRIGQVLKQKLSIPD 189

  Fly   205 HQ-LQYQLHKDTMCKQGSVIKAVYCV 229
            .: |:|::|||:..:..|.:|...|:
Worm   190 TEILRYEVHKDSSARTSSTVKPRICL 215

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF4E4	NP_648052.1	IF4E	56..209	CDD:279921	71/159 (45%)
ife-3	NP_503123.1	IF4E	36..195	CDD:279921	71/159 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156153
Domainoid	1	1.000	173	1.000	Domainoid score	I2208
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H123817
Inparanoid	1	1.050	197	1.000	Inparanoid score	I2501
Isobase	1	0.950	-	0	Normalized mean entropy	S964
OMA	1	1.010	-	-		QHG54586
OrthoDB	1	1.010	-	-		D1394271at2759
OrthoFinder	1	1.000	-	-		FOG0000666
OrthoInspector	1	1.000	-	-		otm14399
orthoMCL	1	0.900	-	-		OOG6_100627
Panther	1	1.100	-	-	O	PTHR11960
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R595
SonicParanoid	1	1.000	-	-		X406
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.890