DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIA and Ir75b

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	NP_001137966.2	Gene:	Ir75b / 8673994	FlyBaseID:	FBgn0261402	Length:	605	Species:	Drosophila melanogaster

Alignment Length:	567	Identity:	108/567 - (19%)
Similarity:	191/567 - (33%)	Gaps:	167/567 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   456 HSHNYASSSRSASASTGD---------YDRNHTYIVSSLLEEPYLSLKQYTYGESLVG------- 504
            |.:::....||.:.|..:         .|.:.||:......:.:|....|..|..|.|
  Fly    91 HRYHWLIYDRSMNFSVLESHFKEAQIFVDADVTYVTHDPFSKNFLLYDVYNKGRQLGGELNITAD 155

  Fly   505 --------NDRFEGYCKDLADMLAAQ-------------------------------LGIKYEIR 530
                    |.|.|.|..:|....|.|                               :..||.|:
  Fly   156 REIFCNKTNCRVERYLSELYTRSALQHRKSFTGLTMRATAVVTALPLNVSIKEIFDFMNSKYRIQ 220

  Fly   531 LVQDGNYGAE------------------NQYAPG-GWDGMVGELIRKEADIAISAMTITAERERV 576
            |......|.:                  ::::.| ...||:|:||..:||:||:....:.:|...
  Fly   221 LDTYARLGYQARQPLRDMLDCKFKYIFRDRWSDGNATGGMIGDLILDKADLAIAPFIYSFDRALF 285

  Fly   577 IDFSKPFMTLGISIMIKKPVKQTPGVFS--FLNPLSQEIWI--SVILSYVG----VSFVLYFVTR 633
            :.....|.......|.:.|...:.|:.:  ||.|.|..:|:  :::|...|    |:|:|
  Fly   286 LQPITKFSVFREICMFRNPRSVSAGLSATEFLQPFSGGVWLTFALLLLLAGCLLWVTFIL----- 345

  Fly   634 FPPYEWRIVRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGCDI 698
                    .||.|     .:|                        ::|.|...|..|...||..:
  Fly   346 --------ERRKQ-----WKP------------------------SLLTSCLLSFGAGCIQGAWL 373

  Fly   699 TPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVA-PIKT---------PEDLTMQTDVN 753
            ||.|:.||:|     ||.:::.|....|....:.|.:::. |||:         ..:|.:..:..
  Fly   374 TPRSMGGRMA-----FFALMVTSYLMYNYYTSIVVSKLLGQPIKSNIRTLQQLADSNLDVGIEPT 433

  Fly   754 YGTLLYGSTWE------FFRRSQIGLH---NKMWEYMNANQHHSVHTYDEGIRRVRQSKGKYALL 809
            ..|.:|..|.|      .:|:..:|..   :|:|          :.| :.|:..||..:|...:.
  Fly   434 VYTRIYVETSEEPDVRDLYRKKVLGSKRSPDKIW----------IPT-EAGVLSVRDQEGFVYIT 487

  Fly   810 VESPKNEYVN----ARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRN 870
            ..:...|:|.    |...|:..::... |...........||..:.:..:.|.:.|.|...:...
  Fly   488 GVATGYEFVRKHFLAHQICELNEIPLR-DASHTHTVLAKRSPYAELIKLSELRMLETGVHFKHER 551

  Fly   871 KWWFDKTECNLDQETSTPNELSLSNVAGIYYILIGGLLLAVIVAIME 917
            .|...|..|.....|..   :.|...|.::.||:|.::|.:.:..:|
  Fly   552 SWMETKLHCYQHNHTVA---VGLEYAAPLFIILLGAIILCMGILGLE 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375
		ANF_receptor	53..434	CDD:279440
		PBP2_iGluR_AMPA	477..879	CDD:270433	94/497 (19%)
		Lig_chan	612..907	CDD:278489	63/323 (20%)
Ir75b	NP_001137966.2	Periplasmic_Binding_Protein_Type_2	253..553	CDD:304360	73/358 (20%)
Ir75b	NP_001137966.2	Lig_chan	343..585	CDD:278489	59/303 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462523
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740