Protein Alignment GluRIA and GLR3.3

DIOPT Version :10

• Sequence 1: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: NP_174978.1
• Gene: GLR3.3 / 840859
• AraportID: AT1G42540
• Length: 933
• Species: Arabidopsis thaliana
• Alignment Length: 1014
• Identity: 215/1014 - (21%)
• Similarity: 399/1014 - (39%)
• Gaps: 244/1014 - (24%)

  Fly    10 YLHFICASSIFWPEFSSAQQQQQTVSLTEK-IPLGAIFE--------------------QGTDDV 53
            :|.|:| |.:|          ::|.|...| :.:|:||.                    ....|:
plant     9 FLSFLC-SGLF----------RRTHSEKPKVVKIGSIFSFDSVIGKVAKIAIDEAVKDVNSNPDI 62

  Fly    54 QSAFKYAMLNHNLNVSSRRFELQAYVDVINTADAFKLSRLICNQFSRGVYSMLGAVSPDSFDTLH 118
            .|..|:::...|.|.|.    ....|:.:...:.                .::|.:.|......|
plant    63 LSGTKFSVSMQNSNCSG----FMGMVEALRFMEK----------------DIVGIIGPQCSVVAH 107

  Fly   119 SYS---NTFQMPFVTPWFPEKVLAPSSGLLDFAISMR---PDYHQ--AIIDTIQYYGWQSIIYLY 175
            ..|   |..::|.::....:.|::|    |.|...:|   .|.:|  ||...:.:|||:.:|.::
plant   108 MISHMANELRVPLLSFAVTDPVMSP----LQFPYFIRTTQSDLYQMDAIASIVDFYGWKEVIAVF 168

  Fly   176 DSHD----GLL---------RLQQIYQE-LKPG---NETFRVQMVKRIANVTMAIEFLHTLEDLG 223
            ...|    |:.         ||:..|:. |.|.   |:...:.|:.:|..:...|..:|...:||
plant   169 VDDDFGRNGVAALNDKLASRRLRITYKAGLHPDTAVNKNEIMNMLIKIMLLQPRIVVIHVYSELG 233

  Fly   224 RFSKKRIVLDCPAEMAKEIIVQHVRDIKLGRRTY-----HYLLSGLVMDNHWPSDVVEFGAINIT 283
             |:                :.:..:.:.:....|     .:|.:.|...:..|::.:|    .|.
plant   234 -FA----------------VFKEAKYLGMMGNGYVWIATDWLSTNLDSSSPLPAERLE----TIQ 277

  Fly   284 GFRIV-----DSNRRAVRDFHDSRKRLEPSGQSQSQNAGGPNSLPAISAQAALMYDAVFVLVEAF 343
            |..::     ||:.:  |:|....:::  ||.|.:.|..|           ...||:|.:|....
plant   278 GVLVLRPHTPDSDFK--REFFKRWRKM--SGASLALNTYG-----------LYAYDSVMLLARGL 327

  Fly   344 NRILRKKPDQFRSNHLQRRSHGGSSSSSATGTNESSALLDCNTSKGWVTPWEQGEKISRVLRKVE 408
            ::..:...:...|||....:.|.|.                |.:...:|.::.||.:.:.:....
plant   328 DKFFKDGGNISFSNHSMLNTLGKSG----------------NLNLEAMTVFDGGEALLKDILGTR 376

  Fly   409 IDGLSGEIRFDEDGRRINYTLHVVEMSVNSTLQQVAEWRDDAGL---LP--LHSHNYASSSRSAS 468
            :.||:|:::|..|..|......::.:: .:.::|:..|.:.:||   ||  |::....:.|.|..
plant   377 MVGLTGQLQFTPDRSRTRPAYDIINVA-GTGVRQIGYWSNHSGLSTVLPELLYTKEKPNMSTSPK 440

  Fly   469 AS----TGD-YDRNHTYIVSSLLEE-----PY-LSLKQYTYGESLVGNDR-FEGYCKDLADMLAA 521
            ..    .|: :.:...::.|:..:|     |. :|.|::.  ..:.|.:. |:|:|.|:......
plant   441 LKHVIWPGETFTKPRGWVFSNNGKELKIGVPLRVSYKEFV--SQIRGTENMFKGFCIDVFTAAVN 503

  Fly   522 QLGIKYEIRLVQDGNYGAEN--------QYAPGGWDGMVGELIRKEADIAISAMTITAERERVID 578
            .|.....::.:..|| |.||        ....|.:||:||       |:|     |...|.:::|
plant   504 LLPYAVPVKFIPYGN-GKENPSYTHMVEMITTGNFDGVVG-------DVA-----IVTNRTKIVD 555

  Fly   579 FSKPFMTLGISIMIKKPVKQ-TPGVFSFLNPLSQEIWISVILSYVGVSFVLYFVTRFPPYEWRIV 642
            |::|:...|  :::..|.|: ..|.::||.|.::.:|......::.|..|::.:......|:|
plant   556 FTQPYAASG--LVVVAPFKKLNSGAWAFLRPFNRLMWAVTGCCFLFVGIVVWILEHRTNDEFR-- 616

  Fly   643 RRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPNE--FTMLNSFWYSLAAFMQQGCDITPPSIAG 705
                                          .||..  .|:|   |:|.:.......:.| .|..|
plant   617 ------------------------------GPPKRQCVTIL---WFSFSTMFFAHRENT-VSTLG 647

  Fly   706 RIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKTPEDLTMQTD-VNYGTLLYGSTWEFFRRS 769
            |:...:|.|..:|:.|||||:|.:.|||:::.:|||..|.|..:.| :.|..   ||..|.:.|:
plant   648 RLVLIIWLFVVLIINSSYTASLTSILTVQQLSSPIKGIESLRERDDPIGYQV---GSFAESYLRN 709

  Fly   770 QIGLHNKMWEYMNANQHHSVHTYDEGIRRVRQSKGKYALLVESPKNEYVN--ARPPCDTMKVGRN 832
            ::.:.......:...:.::....|      ..|||..|.:|:  :..||.  ....|....||:.
plant   710 ELNISESRLVPLGTPEAYAKALKD------GPSKGGVAAIVD--ERPYVELFLSSNCAYRIVGQE 766

  Fly   833 IDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFDKTECNLDQETSTPNELSLSNVA 897
            ....|:|.|.|..|||...|:.|:|.|.|||:|.||.:||.. |..|.|:......:.|.|.:..
plant   767 FTKSGWGFAFPRDSPLAIDLSTAILELAENGDLQRIHDKWLM-KNACTLENAELESDRLHLKSFW 830

  Fly   898 GIYYILIGGLLLAVIVAIMEFFCRNKTPQLKSPGSNGSA 936
            |::  ||.|  :|.::|:..:|.:......|.|..:..|
plant   831 GLF--LICG--VACLLALFLYFVQIIRQLYKKPTDDAIA 865

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..456	CDD:380603	85/474 (18%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	104/422 (25%)
		Lig_chan	610..906	CDD:459656	76/300 (25%)
GLR3.3	NP_174978.1	PBP1_GABAb_receptor_plant	30..423	CDD:380645	83/469 (18%)
		GluR_Plant	464..807	CDD:270404	101/406 (25%)