Protein Alignment GluRIA and GLR3.4

DIOPT Version :10

• Sequence 1: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: NP_172012.2
• Gene: GLR3.4 / 839268
• AraportID: AT1G05200
• Length: 959
• Species: Arabidopsis thaliana
• Alignment Length: 1053
• Identity: 226/1053 - (21%)
• Similarity: 381/1053 - (36%)
• Gaps: 286/1053 - (27%)

  Fly    14 ICASSIFW---------PEFSSAQQQQQTVSL------TEKIPLGAIF--------------EQG 49
            :|. |:.|         ..||.......:.||      ...:.:||:|              :..
plant    21 LCV-SVLWVVPKECACRSNFSRNSSSSSSSSLRPLRQRPSSVNVGALFTYDSFIGRAAKPAVKAA 84

  Fly    50 TDDV---QSAFKYAMLN---HNLNVSSRRFELQAYVDVINTADAFKLSRLICNQFSRGVYSMLGA 108
            .|||   ||..|...||   .:.|.|.          .|.|..|.:|..          ..::.|
plant    85 MDDVNADQSVLKGIKLNIIFQDSNCSG----------FIGTMGALQLME----------NKVVAA 129

  Fly   109 VSPDSFDTLH--SY-SNTFQMPFVTPWFPEKVLAPSSGLLDFAISMRP---DYHQ--AIIDTIQY 165
            :.|.|....|  || :|...:|.::....:    |:...|.|...:|.   ||.|  ||.|.:.|
plant   130 IGPQSSGIAHMISYVANELHVPLLSFGATD----PTLSSLQFPYFLRTTQNDYFQMHAIADFLSY 190

  Fly   166 YGWQSIIYLY----DSHDGLLRLQQIYQE----------LKPGNETFRVQMVKRIANVTMAIEFL 216
            .||:.:|.::    ...:|:..|..:..:          :.||.::..::.:....|:
plant   191 SGWRQVIAIFVDDECGRNGISVLGDVLAKKRSRISYKAAITPGADSSSIRDLLVSVNL------- 248

  Fly   217 HTLEDLGRFSKKRIVLDCPAEMAKEIIVQHVR-DIKLG----RRTYHYLLSGLV----------M 266
                                 |...:.|.||. |..|.    .::...:.||.|          |
plant   249 ---------------------MESRVFVVHVNPDSGLNVFSVAKSLGMMASGYVWIATDWLPTAM 292

  Fly   267 DN--HWPSDVVEF--GAINITGFRIVDSNRRAVRDFHDSRKRLEPSGQSQSQNAGGPNSLPAISA 327
            |:  |..||.::.  |.:....:.|..|.:   |.|....|.|.|       |.|       .::
plant   293 DSMEHVDSDTMDLLQGVVAFRHYTIESSVK---RQFMARWKNLRP-------NDG-------FNS 340

  Fly   328 QAALMYDAVFVLVEAFNRILRKKPDQFRSNHLQRRSHGGSSSSSATGTNESSALLDCNTSKGWVT 392
            .|...||:|:::..|.:...|:..:...||........||       |.:.|||          :
plant   341 YAMYAYDSVWLVARALDVFFRENNNITFSNDPNLHKTNGS-------TIQLSAL----------S 388

  Fly   393 PWEQGEKISRVLRKVEIDGLSGEIRFDEDGRRINYTLHVVEMSVNSTLQQVAEWRDDAGLLPLHS 457
            .:.:|||..:::..:...|::|.|:||.|..|:|....|:.:. .:..:.|..|.:.:||..:|.
plant   389 VFNEGEKFMKIILGMNHTGVTGPIQFDSDRNRVNPAYEVLNLE-GTAPRTVGYWSNHSGLSVVHP 452

  Fly   458 HNYASSSRSASASTGDYDRNHTYIVSSLLEEP------------------YLSLKQYTYGESLVG 504
            ...  .||..:.||.:...........:.:.|                  .:|...|      |.
plant   453 ETL--YSRPPNTSTANQRLKGIIYPGEVTKPPRGWVFPNNGKPLRIGVPNRVSYTDY------VS 509

  Fly   505 NDR----FEGYCKDLADMLAAQLGIKYEIR----LVQDGNYGAENQYAPGGWDGMVGELIRKEAD 561
            .|:    ..|||.|:.: .|.:| :.|.:.    |..||....       .:|.:|.|::....|
plant   510 KDKNPPGVRGYCIDVFE-AAIEL-LPYPVPRTYILYGDGKRNP-------SYDNLVNEVVADNFD 565

  Fly   562 IAISAMTITAERERVIDFSKPFMTLGISIMIK-KPVKQTPGVFSFLNPLSQEIWISVILSYVGVS 625
            :|:..:||...|.|.:||::||:..|:.::.. |..|.:|  :|||.|.:.|:|......::.|.
plant   566 VAVGDITIVTNRTRYVDFTQPFIESGLVVVAPVKEAKSSP--WSFLKPFTIEMWAVTGGFFLFVG 628

  Fly   626 FVLYFVTRFPPYEWRIVRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPNEFTMLNSFWYSLAA 690
            .:::.:......|:|                                .||.. .::..||:|.:.
plant   629 AMVWILEHRFNQEFR--------------------------------GPPRR-QLITIFWFSFST 660

  Fly   691 FMQQGCDITPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKTPEDLTMQTD---V 752
            ......:.|..|: ||....:|.|..:|:.|||||:|.:.||:.::.:.|:..:.|....:   |
plant   661 MFFSHRENTVSSL-GRFVLIIWLFVVLIINSSYTASLTSILTIRQLTSRIEGIDSLVTSNEPIGV 724

  Fly   753 NYGTLLYGSTWEFFRRSQIGLHNKMWEYMNANQHHSVHTYDE-----GIRRVRQSKGKYALLVES 812
            ..||         |.|      |.:...:|......|...||     .::|...:.|..|::.|.
plant   725 QDGT---------FAR------NYLINELNILPSRIVPLKDEEQYLSALQRGPNAGGVAAIVDEL 774

  Fly   813 PKNEYVNARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFDKT 877
            |..|.:.....|....||:.....|:|.|....|||...::.|:|.|.|.|||.:|..||...|.
plant   775 PYIEVLLTNSNCKFRTVGQEFTRTGWGFAFQRDSPLAVDMSTAILQLSEEGELEKIHRKWLNYKH 839

  Fly   878 ECNLDQETSTPNELSLSNVAGIYYILIGGLLLAVIVAIMEFFCR---------------NKTPQL 927
            ||::....|..::|||.:..|::  ||.|  :...:|:..||.|               .:..::
plant   840 ECSMQISNSEDSQLSLKSFWGLF--LICG--ITCFMALTVFFWRVFWQYQRLLPESADEERAGEV 900

  Fly   928 KSPGSNGSAGGVP 940
            ..|..:|.....|
plant   901 SEPSRSGRGSRAP 913

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..456	CDD:380603	98/475 (21%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	99/436 (23%)
		Lig_chan	610..906	CDD:459656	72/303 (24%)
GLR3.4	NP_172012.2	PBP1_GABAb_receptor_plant	62..450	CDD:380645	98/474 (21%)
		Lig_chan-Glu_bd	507..591	CDD:463166	26/98 (27%)
		Lig_chan	613..867	CDD:459656	73/306 (24%)