DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIA and GLR2.5

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	NP_001332219.1	Gene:	GLR2.5 / 830991	AraportID:	AT5G11210	Length:	918	Species:	Arabidopsis thaliana

Alignment Length:	1073	Identity:	224/1073 - (20%)
Similarity:	396/1073 - (36%)	Gaps:	289/1073 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LKFLAYLHFICASSIFWPEFSSAQQQQQTVSLTEKIPLGAIFEQGTDDVQSAFKYAMLNHNLNVS 69
            |..|.:|.|:.        .|..:.|::.:.:...|.||:                      ||:
plant    14 LWLLIFLVFLV--------LSLGKSQKEALQVKVGIVLGS----------------------NVT 48

  Fly    70 SRRFELQA----YVDVINTADAFKLSRLICNQ------------------FSRGVYSMLGAVSPD 112
            .....|:|    ..:..||.:.|| :|::.|.                  ..|.|.:::|..:..
plant    49 LADLSLRAINMSLSEFYNTHNGFK-TRIVLNVRDSKQTVVGAAASALYLIKKREVVAIIGPGTSM 112

  Fly   113 SFDTLHSYSNTFQMPFVTPWFPEKVLAPSSGLLDFAISMRPDYH-----------QAIIDTIQYY 166
            ....|.:..|..::|.::       .:.:|.|||   |:|..|.           |||...|:.:
plant   113 QAPFLINLGNQSKVPIIS-------FSATSPLLD---SLRSPYFIRATHDDSSQVQAISAIIESF 167

  Fly   167 GWQSIIYLY---DSHDGLL-RLQQIYQE------------LKPGNETFRVQMVKRIANVTMAIEF 215
            .|:.::.:|   :..:|:| .|...:||            |...::..:.::.| :..:...:..
plant   168 RWREVVPIYVDNEFGEGILPNLVDAFQEINVRIRYRSAISLHYSDDQIKKELYK-LMTMPTRVFI 231

  Fly   216 LHTLEDLGR--FSKKRIVLDCPAEMAKEIIVQHVRDIKLGRRTYHYLLSGLVMDNHWPSDVVEFG 278
            :|.|.|||.  ||           :|||        |.:..:.|.::::..:.|  ..|.:.|..
plant   232 VHMLPDLGSRLFS-----------IAKE--------IDMLSKGYVWIVTNGIAD--LMSIMGESS 275

  Fly   279 AINITGFRIVDSNRRAVRDFHDSRKRLEPSGQSQSQNAGGPNSLPAISAQAALMYDAVFVLVEAF 343
            .:|:.|...|.:.      |..|::.|....:.|.:..|     ..::..|...|||...|..:.
plant   276 LVNMHGVLGVKTY------FAKSKELLHLEARWQKRFGG-----EELNNFACWAYDAATALAMSV 329

  Fly   344 NRILRKKPDQFRSNHLQRRSHGGSSSSSATGTNESSALLDCNTSKGWVTPWEQGEKISRVLRKVE 408
            ..|          .|:         :.|...|.|.::..|..|....:.....|.|:...|..|.
plant   330 EEI----------RHV---------NMSFNTTKEDTSRDDIGTDLDELGVALSGPKLLDALSTVS 375

  Fly   409 IDGLSGEIRFDEDGRRINYTLHVVEMSVNSTLQQVAEWRDDAGLL-PLHSHNYASSSRSASAS-- 470
            ..|::|..:. ::|:....|..::.:. .|..:.|..|:...||: .|.....:.|||.....
plant   376 FKGVAGRFQL-KNGKLEATTFKIINIE-ESGERTVGFWKSKVGLVKSLRVDKVSHSSRRLRPIIW 438

  Fly   471 TGDYDRNHTYIVSSLLEEPYLSLKQYTYGESLVGNDRF--------------EGYCKDLADMLAA 521
            .||     |..|....|.|..:.|.........|.:.|              .|:|.|:.:.:.:
plant   439 PGD-----TIFVPKGWEFPTNAKKLRIAVPKKDGFNNFVEVTKDENTNVPTVTGFCIDVFNTVMS 498

  Fly   522 QLGIKYEIRLVQDGNYGAENQYAP---------GGWDGMVGELIRKEADIAISAMTITAERERVI 577
            |:            .|....:|.|         |.:|.||..:...|.|.|:...||.|.|...:
plant   499 QM------------PYAVSYEYIPFDTPDGKPRGSYDEMVYNVFLGEFDGAVGDTTILANRSHYV 551

  Fly   578 DFSKPFMTLGISIMIKKPVK--QTPGVFSFLNPLSQEIWISVILSYVGVSFVLYFVTRFPPYEWR 640
            ||:.|:...||..::  |||  :..|.:.||.||::|:|:....|::.:..:::.      :|:
plant   552 DFALPYSETGIVFLV--PVKDGKEKGEWVFLKPLTKELWLVTAASFLYIGIMVWI------FEY- 607

  Fly   641 IVRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGCDITPPSIAG 705
                 |||...::...|                  ::.:.:..|.:|...|..:.   ...|...
plant   608 -----QADEEFREQMII------------------DKISSVFYFSFSTLFFAHRR---PSESFFT 646

  Fly   706 RIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKTPEDLTMQTDVNYGTLLYGSTWE-----F 765
            |:...||.|..:||..||||.|.:.|||:.:...::..:|| .::.||.|......|:|     .
plant   647 RVLVVVWCFVLLILTQSYTATLTSMLTVQELRPTVRHMDDL-RKSGVNIGYQTGSFTFERLKQMR 710

  Fly   766 FRRSQIGLHNKMWEYMNANQHHSVH-----TYDEGIRRVRQSKGKYALLVESPKNEYVNARPPCD 825
            |..|::..:|...|......|.|.:     .:|| :..::....||.       :||....|
plant   711 FDESRLKTYNSPEEMRELFLHKSSNGGIDAAFDE-VAYIKLFMAKYC-------SEYSIIEP--- 764

  Fly   826 TMKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFDKTECNLDQETS-TPN 889
            |.|      ..|||.|.|:||||...::..:|.:.|...:..|.|||:..:..| ||..|| :|.
plant   765 TFK------ADGFGFAFPLGSPLVSDISRQILNITEGDAMKAIENKWFLGEKHC-LDSTTSDSPI 822

  Fly   890 ELSLSNVAGIYYILIGGLLLAVIVAIMEFFCRNKTPQLKSPGSNGSAGGVPGMLASSTYQ--RDS 952
            :|...:...::.|:   .:::||:.::                         ||||..||  :.:
plant   823 QLDHHSFEALFLIV---FVVSVILLLL-------------------------MLASRGYQERQHN 859

  Fly   953 LSDAIMHSQAKLAMQASSE---YDERLVGVELA 982
            .|..:.:.||..|.:..:|   ..:.:|.|:.|
plant   860 ASPNLPNDQANAAQEEVNEEGNVGDHIVEVDTA 892

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375	85/462 (18%)
		ANF_receptor	53..434	CDD:279440	79/431 (18%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	101/436 (23%)
		Lig_chan	612..907	CDD:278489	71/305 (23%)
GLR2.5	NP_001332219.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.920