Protein Alignment GluRIA and GLR2.6

DIOPT Version :10

• Sequence 1: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: NP_001330285.1
• Gene: GLR2.6 / 830988
• AraportID: AT5G11180
• Length: 967
• Species: Arabidopsis thaliana
• Alignment Length: 1052
• Identity: 225/1052 - (21%)
• Similarity: 372/1052 - (35%)
• Gaps: 326/1052 - (30%)

  Fly    28 QQQQQTVSLTEKIPLGAIFEQGTDDVQSAFKYAMLNHNLNVSSRRFELQAYVDVINTADAFKLSR 92
            :.||:.:    ::.:|.:.:  |:...:|.....:|.:|:            :..||.:.|| :|
plant    28 KSQQEVL----QVQVGIVLD--TNATLAALSLRAINMSLS------------EFYNTHNGFK-TR 73

  Fly    93 LICN------------------QFSRGVYSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLA 139
            ::.|                  ...|.|.:::|..:......|.:..|..|:|.::       .:
plant    74 IVLNIRDSKRTVVGAAASALYLIKKREVVAIIGPGNSMQAPFLINLGNQSQVPIIS-------FS 131

  Fly   140 PSSGLLDFAISMRPDYH-----------QAIIDTIQYYGWQSIIYLYDSH---DGLL-RLQQIYQ 189
            .||.:||   |:|..|.           .||...|:.:.|:.::.:|..:   :|:| .|...:|
plant   132 ASSPVLD---SLRSPYFIRATHDDSSQVHAISAIIESFRWREVVPIYADNEFGEGILPYLVDAFQ 193

  Fly   190 ELKPGNETFRVQ----------MVK----RIANVTMAIEFLHTLEDLGR--FSKKRIVLDCPAEM 238
            |:   |...|.:          :||    ::..:...:..:|.|.|||.  ||           :
plant   194 EI---NVRIRYRSAISVHSTDDLVKKELYKLMTMPTRVFIVHMLPDLGSRLFS-----------I 244

  Fly   239 AKEIIVQHVRDIKLGRRTYHYLLSGLVMDNHWPSDVVEFGAINITGFRIVDSNRRAVRDFHDSRK 303
            ||||          |..|..|:         |   :|..|        |.|
plant   245 AKEI----------GMMTKGYV---------W---IVTNG--------IAD-------------- 265

  Fly   304 RLEPSGQSQSQNAGGPNSLPA-ISAQAALMY-------------------------DAVFVLVEA 342
            ::...|:|..:|..|...:.. .|....|||                         .|:.:.:|.
plant   266 QMSVMGESSLENMHGVLGVKTYFSRSKELMYLETRWRKRFGGEELNNFECWGYDTATALAMSIEE 330

  Fly   343 FNRILRKKPDQFRSNHLQRRSHGGSSSSSATGT---NESSALLDCNTSKGWVTPWEQGEKISRVL 404
            .:..:.....|.:.|          :|...|||   :.|.||              .|.|:.:.|
plant   331 ISSNVNMSFSQTKRN----------TSRDDTGTDLDDLSFAL--------------SGPKLLQAL 371

  Fly   405 RKVEIDGLSGEIRFDEDGRRINYTLHVVEMSVNSTLQQVAEWRDDAGLLPLHSHNYASSSRSASA 469
            ..|...|::|..:. ::|:....|..:|.:. .|..:.|..|:...||:.....|......|.|:
plant   372 ATVSFKGVAGRFQL-KNGKLEATTFKIVNIE-ESGERTVGFWKSKVGLVKSLRVNQTGIKISHSS 434

  Fly   470 S-------TGDYDRNHTYIVSSLLEEPYLSLKQYTYGESLVGNDRF--------------EGYCK 513
            .       .||     |..|....|.|..:.|.........|.:.|              .|:|.
plant   435 HRLRPIIWPGD-----TIFVPKGWEFPTNAKKLRIAVPKKDGFNNFVEVTKDANTNAPTITGFCI 494

  Fly   514 DLADMLAAQLGIKYEIRLVQDGNYGAENQYAP---------GGWDGMVGELIRKEADIAISAMTI 569
            |:.|....|:            .|....:|.|         |.:|.||..:...|.|.|:...||
plant   495 DVFDTAMRQM------------PYAVPYEYIPFETPDGKPRGSYDEMVYHVFLGEFDGAVGDTTI 547

  Fly   570 TAERERVIDFSKPFMTLGISIMIKKPVK--QTPGVFSFLNPLSQEIWISVILSYVGVSFVLYFVT 632
            .|.|...:||:.|:...||.:::  |||  :..|.:.||.||::|:|.....|::.:..::
plant   548 LANRSTYVDFALPYSETGIVVVV--PVKDEREKGKWVFLKPLTRELWFLTAASFLYIGIMV---- 606

  Fly   633 RFPPYEWRIVRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPNEFTMLNSFWYSLA----AFMQ 693
                  |....:...|...|   .||                 |:.:  |.|::|.:    |.|:
plant   607 ------WIFEYQASGDFRKQ---SII-----------------NKIS--NVFYFSFSTLFFAHMR 643

  Fly   694 QGCDITPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKTPEDLTMQTDVNYGTLL 758
            ..     .||..|:...||.|..:||..||||.|.:.|||:.:...::..:|| ..:.||.|...
plant   644 PS-----ESIFTRVLVVVWCFVLLILTQSYTATLTSMLTVQELRPTVRHMDDL-RNSGVNIGYQT 702

  Fly   759 YGSTWEFFRRSQIGL-HNKMWEYMNANQHHSVH-----------TYDEGIRRVRQSKGKYALLVE 811
            ...|:|  |..|:|. .:::..|....:.|.:.           .:|| :..|:....||.
plant   703 GSFTFE--RLKQMGYKESRLKTYDTPQEMHELFLKKSSNGGIDAAFDE-VAYVKLFMAKYC---- 760

  Fly   812 SPKNEYVNARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFDK 876
               ::|....|   |.|      ..|||.|.|:||||...|:..:|.:.|...:..|.|||...:
plant   761 ---SKYTIIEP---TFK------ADGFGFAFPLGSPLVPDLSRQILNITEGETMKAIENKWLLGE 813

  Fly   877 TECNLDQETS-TPNEL---SLSNVAGIYYILIGGLLLAVIVAIMEFFCRNKTPQLKSPGSNGSAG 937
            ..| ||..|| :|..|   |...:..|.:::...||||::|      ||....:.||...|.:..
plant   814 KHC-LDSTTSDSPIRLDHHSFEALFTIVFVVSMLLLLAMLV------CRRYRQESKSGEINANNS 871

  Fly   938 GVPGMLASSTYQ 949
            ...|.:.:...|
plant   872 PTDGNMRAPPNQ 883

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..456	CDD:380603	91/492 (18%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	106/442 (24%)
		Lig_chan	610..906	CDD:459656	76/315 (24%)
GLR2.6	NP_001330285.1	PBP1_GABAb_receptor_plant	38..421	CDD:380645	91/491 (19%)
		GluR_Plant	460..810	CDD:270404	101/420 (24%)
		Lig_chan	590..842	CDD:459656	76/309 (25%)