DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIA and GLR3.6

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	NP_001326369.1	Gene:	GLR3.6 / 824311	AraportID:	AT3G51480	Length:	903	Species:	Arabidopsis thaliana

Alignment Length:	855	Identity:	182/855 - (21%)
Similarity:	332/855 - (38%)	Gaps:	220/855 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   140 PSSGLLDFAISMRPDYHQ-----AIIDTIQYYGWQSIIYLYDSHD----GLLRLQQIYQELK--- 192
            |:...|.|...:|...:.     ||.|.:|:|||:.::.:|...|    |:..|.....|.:
plant   129 PTMSPLQFPFFIRTSQNDLFQMAAIADIVQFYGWREVVAIYGDDDYGRNGVAALGDRLSEKRCRI 193

  Fly   193 ---------PGNETFRVQMVK------RI----ANVTMAIEFLHTLEDLGRFSKKRI-------- 230
                     |..|.....::|      ||    |:....:|..:...:||..|...:
plant   194 SYKAALPPAPTRENITDLLIKVALSESRIIVVHASFIWGLELFNVARNLGMMSTGYVWIATNWLS 258

  Fly   231 -VLDCPAEMAKEII--VQHVRDIKLGRRTYHYLLSGLVMDNHWPSDVVEFGAINITGFRIVDSNR 292
             ::|..:.:..:.|  :|.|..::|                |.|:.:::               :
plant   259 TIIDTDSPLPLDTINNIQGVITLRL----------------HTPNSIMK---------------Q 292

  Fly   293 RAVRDFHDSRKRLEPSGQSQSQNAGGPNSLPAISAQAALMYDAVFVLVEAFNRILRKKPD-QFRS 356
            ..|:.:|:    |...|               :|..|...||.|::|.:|.:...:|..: .|..
plant   293 NFVQRWHN----LTHVG---------------LSTYALYAYDTVWLLAQAIDDFFKKGGNVSFSK 338

  Fly   357 NHLQRRSHGGSSSSSATGTNESSALLDCNTSKGWVTPWEQGEKISRVLRKVEIDGLSGEIRFDED 421
            |.:.....||:....|                  :..::.|:.....:.:|:..||:|.::|..|
plant   339 NPIISELGGGNLHLDA------------------LKVFDGGKIFLESILQVDRIGLTGRMKFTSD 385

  Fly   422 GRRINYTLHVVEMSVNSTLQQVAEWRDDAGLLPLHSHNYASSSRSASASTGDYDRNHTYIVSSLL 486
            ...:|....|:.: :.:....:..|.:.:||..:.:....::|.|.       .:.|:.:
plant   386 RNLVNPAFDVLNV-IGTGYTTIGYWFNHSGLSVMPADEMENTSFSG-------QKLHSVV----- 437

  Fly   487 EEPYLSLK--------------------QYTYGE--SLVGNDRFEGYCKDLADMLAAQLGIKYEI 529
             .|..|:|                    :|.:.|  |:..|....|:|.|:  .:||...:.|.:
plant   438 -WPGHSIKIPRGWVFSNNGRHLRIGVPNRYRFEEVVSVKSNGMITGFCVDV--FIAAINLLPYAV 499

  Fly   530 --RLVQDGNYGAENQYAPGGWDGMVGELIRKEA----DIAISAMTITAERERVIDFSKPFMTLGI 588
              .||..|| |.:|   |..     .||:|...    |..:..:||..||.::.||::|::..|
plant   500 PFELVAFGN-GHDN---PSN-----SELVRLITTGVYDAGVGDITIITERTKMADFTQPYVESG- 554

  Fly   589 SIMIKKPVKQT-PGVFSFLNPLSQEIWISVILSYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQ 652
             :::..||::. ....:||.|.:.::|:....|::.|..|::.:......|:|
plant   555 -LVVVAPVRKLGSSAMAFLRPFTPQMWLIAAASFLIVGAVIWCLEHKHNDEFR------------ 606

  Fly   653 QPPGIIGGATLSEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGCDITPPSIAGRIAAAVWWFFTI 717
                                .||.. .::.:||:|.:.......:.|..:: |||...:|.|..:
plant   607 --------------------GPPRR-QVITTFWFSFSTLFFSHRETTTSNL-GRIVLIIWLFVVL 649

  Fly   718 ILISSYTANLAAFLTVERMVAPIKTPEDLTMQTDVNYGTLLY--GSTWEFFRRSQIGLHNKMWEY 780
            |:.|||||:|.:.|||.::.:|||..|  |:||  |:..:.|  ||....:...::.:|......
plant   650 IINSSYTASLTSILTVHQLSSPIKGIE--TLQT--NHDPIGYPQGSFVRDYLIHELNIHVSRLVP 710

  Fly   781 MNANQHHSVHTYDEGIRRVRQSKGKYALLVESPKNEYVN--ARPPCDTMKVGRNIDTKGFGVATP 843
            :     .|...||:.:|. ...||..|.:|:  :..|:.  ....|:...||:.....|:|.|.|
plant   711 L-----RSPEEYDKALRD-GPGKGGVAAVVD--ERAYIELFLSNRCEFGIVGQEFTKNGWGFAFP 767

  Fly   844 IGSPLRKRLNEAVLTLKENGELLRIRNKWWFDKTECNLDQETSTPNELSLSNVAGIYYI--LIGG 906
            ..|||...::.|:|.|.|||::.|||:||...|. |:|.......:.|.|.:..|::.:  :...
plant   768 RNSPLAVDVSAAILQLSENGDMQRIRDKWLLRKA-CSLQGAEIEVDRLELKSFWGLFVVCGVACV 831

  Fly   907 LLLAVIVAIM 916
            |.|||...:|
plant   832 LALAVYTVLM 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375	61/355 (17%)
		ANF_receptor	53..434	CDD:279440	59/336 (18%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	108/434 (25%)
		Lig_chan	612..907	CDD:278489	75/300 (25%)
GLR3.6	NP_001326369.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.820