DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIA and GLR1.4

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	NP_187408.2	Gene:	GLR1.4 / 819940	AraportID:	AT3G07520	Length:	861	Species:	Arabidopsis thaliana

Alignment Length:	1034	Identity:	196/1034 - (18%)
Similarity:	355/1034 - (34%)	Gaps:	355/1034 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 FLAYLHFICASSIFWPEFSSAQQQQQTVS----LTEKIPLGAIFEQGTDD---VQSAFKYAM--- 61
            |||::.|...        .|...|:..|.    :.|.:.:|.:.:.|:.:   |.::...|:
plant    17 FLAFISFAVT--------CSGTNQKDNVDRLPVVYEDVRIGLVVDMGSMEGKLVTTSISMALSDF 73

  Fly    62 --LNH----NLNVSSRRFE------LQAYVDVINTADAFKLSRLICNQFSRGVYSMLGAVSPDSF 114
              :|:    .::|.||...      |.|.:|::.|..               |.:::|..|....
plant    74 YHVNNGYRTRVSVLSRDSHGDPLQALAAAMDLLQTEQ---------------VEALVGGQSLLEA 123

  Fly   115 DTLHSYSNTFQMPFVTPWFPEKVLAPSSGLLDFAISMRPDYHQAIIDT----------IQYYGWQ 169
            ..|.......::|.::.:     ..|||    .:::....:.||..||          ...:.|:
plant   124 KNLAELGEKTKVPVISSF-----QVPSS----LSLAKYNYFIQATHDTSSEAKGIAALFSNFDWR 179

  Fly   170 SIIYLYDSHDGLLRLQQIYQELKPGNETFRVQMVKRIANVTMAIEFLHTLEDL-GRFSKKRIVLD 233
            :.:.:|:..|                                  ::..:::.| |.|.:..|.::
plant   180 TAVLIYEDDD----------------------------------DWRESIQPLVGHFQQNAIHIE 210

  Fly   234 CPAEMA----KEIIVQHVRDIKL-GRRTYHYLLSGLVMDNHWPS----DVVEFGAINITGFRIVD 289
            ..||.:    :|.|::.:|..|. |.|.:...:|..:.:..:|.    .::|.|...|.
plant   211 YKAEFSVSSNEECIMKQLRKFKASGIRIFVAHISERIANRLFPCARRLGMMEEGYAWIL------ 269

  Fly   290 SNRRAVRDFHDSRKRLEPSGQSQSQNAGGPNSLPAISAQAALMYDAVFVLVEAF-NRILRKKPDQ 353
             ..|::.:|.|:                  |.|.....:..:.:.:...|.|.. |..||.|
plant   270 -TARSMNNFQDT------------------NYLAKEEMEGVIGFKSYIPLTEELHNFTLRWK--- 312

  Fly   354 FRSNHLQRRSHGGSSSSSATGTNESSALLDCNTSKGWV--TPWEQG--------------EKISR 402
             ||..|:                  ..:...:....|.  ..|...              :.:..
plant   313 -RSLRLE------------------EVVTRMSVCSIWAHDIAWSLARAAEVAKLPGLSVYDLLEA 358

  Fly   403 VLRKVEIDGLSGEIRFDEDGRRINYTLHVVEMSVNSTLQQVAEWRDDAGLLPLHSHNYASSSRSA 467
            :....:..||||:|:| .|.:.|:....:|.| :....:.|..|         :|.::.|:.|..
plant   359 IPESAKHKGLSGDIKF-IDKKFISDKFEIVNM-IGRGERSVGLW---------NSGSFISNRRRR 412

  Fly   468 SASTGDYDRNHTYIVSSLLEE----------PYL-SLKQYTYGES-----LV------------- 503
            .:||            ..||.          |.: |||:..:|:.     ||
plant   413 LSST------------KALETIIWPGGSTRIPKIRSLKEKRHGKKKKLRVLVPAGNITPQILEVK 465

  Fly   504 -----GNDRFEGYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAPGGWDGMV-----GELI-- 556
                 |.....|||.|:.:  .:.|...||:            :|.|  |.|.:     .:|:
plant   466 TDFKTGVTAATGYCIDVFE--TSILPFNYEV------------EYIP--WPGAINYKNYNDLVYT 514

  Fly   557 ----RKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPLSQEIWISV 617
                :.:.|.|:..:|||..|...:||:.||..:|::::..|    ...::....||:..:|:::
plant   515 LYSQKDKYDAAVGDITITDNRSLYVDFTLPFTDMGLAVVTAK----DKSMWIIFKPLTLSLWLTI 575

  Fly   618 ILSYVGVSFVLYFVTRFPPYEWRIVRRPQAD---STAQQPPGIIGGATLSEPQAHVPPVPPNEFT 679
            ...::....::          |.|.|...||   |..||    ||                   |
plant   576 ASFFILTGAIV----------WLIERHDNADFQGSCFQQ----IG-------------------T 607

  Fly   680 MLNSFWYSLAAF-----MQQGCDITPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAP 739
            :| .|.:|...|     :|..        ..|....||.|..:||.|:|||.|.:.:||:: :..
plant   608 LL-CFGFSTLVFAHRERLQHN--------MSRFVVIVWIFAVLILTSNYTATLTSVMTVQQ-IRG 662

  Fly   740 IKTPEDLTMQTDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYMNAN------QHHSVHTYDEGIRR 798
            :|:.|        |.|         ||..|...      ..:|.|      ::..:.|.|:....
plant   663 LKSNE--------NIG---------FFSASIAA------NVVNDNPTFQGPRYKGLKTADDFTNA 704

  Fly   799 VRQSKGKYALLV-ESPKNEYVNARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKEN 862
            :|  .|..:.:| |.|..:...|:.|.:.:.|.....|.|||.|...||||.::::..:..|:..
plant   705 LR--NGTISFIVDEVPYVKLFVAKHPSEFVIVETESVTNGFGFAFQKGSPLVQKVSREIEKLRRT 767

  Fly   863 GELLRIRNKWWFDKTECNLDQETSTPNE-----LSLSNVAGIYYILIGGLLLAVIVAIM 916
            .:|..|.| |||.:      |.||..:|     |::....|::.|.......|:||.::
plant   768 EKLKAIEN-WWFQR------QTTSATSEDTFHPLTVYTFRGLFMITGVSFAFALIVYLI 819

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375	72/466 (15%)
		ANF_receptor	53..434	CDD:279440	67/432 (16%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	101/461 (22%)
		Lig_chan	612..907	CDD:278489	72/314 (23%)
GLR1.4	NP_187408.2	PBP1_GABAb_receptor	47..410	CDD:107361	74/478 (15%)
		ANF_receptor	64..390	CDD:279440	67/432 (16%)
		GluR_Plant	448..778	CDD:270404	92/418 (22%)
		Periplasmic_Binding_Protein_Type_2	476..>657	CDD:304360	54/242 (22%)
		Lig_chan	570..810	CDD:278489	72/314 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.910