Protein Alignment GluRIA and GLR1.1

DIOPT Version :10

• Sequence 1: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: NP_187061.1
• Gene: GLR1.1 / 819566
• AraportID: AT3G04110
• Length: 808
• Species: Arabidopsis thaliana
• Alignment Length: 904
• Identity: 176/904 - (19%)
• Similarity: 334/904 - (36%)
• Gaps: 238/904 - (26%)

  Fly    75 LQAYVDVINTADAFKLSRLICNQFSRGVYSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLA 139
            |.|..|::..|.|               .:::||.|......|.:.|...::|.::.:.|..:
plant    83 LAAATDLLKNAKA---------------EAIVGAQSLQEAKLLATISEKAKVPVISTFLPNTL-- 130

  Fly   140 PSSGLLDFAISMRPD---YHQAIIDTIQYYGWQSIIYLYDSHDGLLRLQQIYQELKPGNETFRVQ 201
             |....|..|....|   ..:.|...||.:..:|::.:|:..|......||..      |.|:.:
plant   131 -SLKKYDNFIQWTHDTTSEAKGITSLIQDFSCKSVVVIYEDADDWSESLQILV------ENFQDK 188

  Fly   202 MVKRIANVTMAI------EFLHTLEDLGRFSKKRIVLDCPAEMAKEIIVQHVRDIKLGRRTYHYL 260
            .:....:.:.|:      ..::.|..| :.|:..:.:...:|:....:.|.|..:.|....:.::
plant   189 GIYIARSASFAVSSSGENHMMNQLRKL-KVSRASVFVVHMSEILVSRLFQCVEKLGLMEEAFAWI 252

  Fly   261 LSGLVMDNHWPSDVVEFGAINITGFRIVDSNRRAVRDFHDS-RKRLEPSGQSQSQNAGGPNSLPA 324
            |:...| |:.....:......:.||:........|::|... |||:....:::       :|...
plant   253 LTARTM-NYLEHFAITRSMQGVIGFKSYIPVSEEVKNFTSRLRKRMGDDTETE-------HSSVI 309

  Fly   325 ISAQAALMYDAVFVLVEAFNRILRKKPDQFRSNHLQRRSHGGSSSSSATGTNESSALLDCNTSKG 389
            |..:|   :|...:|                :|.:::.|..|...:|   :|.|:.|||
plant   310 IGLRA---HDIACIL----------------ANAVEKFSVSGKVEAS---SNVSADLLD------ 346

  Fly   390 WVTPWEQGEKISRVLRKVEIDGLSGEIRFDEDGRRINYTLHVVEMSVN-------------STLQ 441
                         .:|.....||||:|:. .|.:.|:.|..:|.:...             |..:
plant   347 -------------TIRHSRFKGLSGDIQI-SDNKFISETFEIVNIGREKQRRIGLWSGGSFSQRR 397

  Fly   442 QVAEWRDDAGLLPLHSHNYASSSRSASASTGDYDRNHTYIVSSLLEEPYL-SLKQYTYGESLVGN 505
            |:. |...:..:|.|         ...|..|: .:....:|::..:.|:| |::.    :...|.
plant   398 QIV-WPGRSRKIPRH---------RVLAEKGE-KKVLRVLVTAGNKVPHLVSVRP----DPETGV 447

  Fly   506 DRFEGYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAPGGWDGMVGELI--RKEADIAISAMT 568
            :...|:|.::.....|.  ..||:..:.   |...|       |.:...|.  |.:.|.|:..:|
plant   448 NTVSGFCVEVFKTCIAP--FNYELEFIP---YRGNN-------DNLAYLLSTQRDKYDAAVGDIT 500

  Fly   569 ITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPLSQEIWISVILSYVGVSFVLYFVTR 633
            ||:.|...:||:.|:..:||.|:..|  |::.|:::|.:|..:.:|::....:|....|::.|.|
plant   501 ITSNRSLYVDFTLPYTDIGIGILTVK--KKSQGMWTFFDPFEKSLWLASGAFFVLTGIVVWLVER 563

  Fly   634 FPPYEWRIVRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPNEFTMLNSFWYSLAAF-----MQ 693
            ....|::       .|..||                        .:|:..|.:|...|     :|
plant   564 SVNPEFQ-------GSWGQQ------------------------LSMMLWFGFSTIVFAHREKLQ 597

  Fly   694 QGCDITPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKTPEDLTMQTDVNYGTLL 758
            :        ::.|....||.|..:||.|||:|||.:..|:.||              .:|:..:.
plant   598 K--------MSSRFLVIVWVFVVLILTSSYSANLTSTKTISRM--------------QLNHQMVF 640

  Fly   759 YGSTWEFFRRSQIGLHNKMWEYMNANQHHSVHTYDEGIRRVRQSKGKYALLVESPKNEYVNARP- 822
            .|||...  .:::|..|            :|..|.:             ||.:...|..:|..|
plant   641 GGSTTSM--TAKLGSIN------------AVEAYAQ-------------LLRDGTLNHVINEIPY 678

  Fly   823 --------PCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFDKTE- 878
                    |.|.:...|..:|.|||.....||.|..:::..:..|:..| :|:...|.||.|.:
plant   679 LSILIGNYPNDFVMTDRVTNTNGFGFMFQKGSDLVPKVSREIAKLRSLG-MLKDMEKKWFQKLDS 742

  Fly   879 ----CNLDQETSTPNE------LSLSNVAGIYYILIGGLLLAVIVAIMEFFCRNKTPQL 927
                .|.::..||.::      .:...:.|::  :|.|....:::|:..|..|.:..:|
plant   743 LNVHSNTEEVASTNDDDEASKRFTFRELRGLF--IIAGAAHVLVLALHLFHTRQEVSRL 799

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..456	CDD:380603	72/403 (18%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	91/423 (22%)
		Lig_chan	610..906	CDD:459656	64/320 (20%)
GLR1.1	NP_187061.1	PBP1_GABAb_receptor_plant	31..397	CDD:380645	69/388 (18%)
		Periplasmic_Binding_Protein_Type_2	421..737	CDD:473866	88/414 (21%)