DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIA and GLR3.5

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	NP_001324013.1	Gene:	GLR3.5 / 817800	AraportID:	AT2G32390	Length:	953	Species:	Arabidopsis thaliana

Alignment Length:	993	Identity:	219/993 - (22%)
Similarity:	374/993 - (37%)	Gaps:	225/993 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 ICASSIFWPEFSSA-----QQQQQTVSLTEKIPLGAIFEQGTDD------VQSAFKYAMLNHNLN 67
            :|.|:::......|     .:...:.||...:.:||:|   |.|      .:.||..|:.:.|.:
plant    17 LCISALWVLPIQGAGRESFSRNSSSSSLPSSVNVGALF---TYDSFIGRAAKLAFVAAIEDINAD 78

  Fly    68 VSSRR-------FELQAYVDVINTADAFKLSRLICNQFSRGVYSMLGAVSPDSFDTLHSYS---N 122
            .|..|       |:.......:.|..|.:|..          ..::.|:.|.|....|..|   |
plant    79 QSILRGTKLNIVFQDTNCSGFVGTMGALQLME----------NKVVAAIGPQSSGIGHIISHVAN 133

  Fly   123 TFQMPFVTPWFPEKVLAPSSGLLDFAISMRP---DYHQ--AIIDTIQYYGWQSIIYLY-DSHDGL 181
            ...:||::    .....|:...|.:...:|.   ||.|  ||.|.:.|:.|:.::.:: |...|
plant   134 ELHVPFLS----FAATDPTLSSLQYPYFLRTTQNDYFQMNAITDFVSYFRWREVVAIFVDDEYG- 193

  Fly   182 LRLQQIYQELKPGNETFRVQMVKRIANVTMAIEF-----LHTLEDLGRFSKKRIVLDCPAEMAKE 241
                      :.|.......:.|:.|.::....|     ..::.||         |.....|...
plant   194 ----------RNGISVLGDALAKKRAKISYKAAFPPGADNSSISDL---------LASVNLMESR 239

  Fly   242 IIVQHVRD----------IKLGRR-------TYHYLLSGLVMDNHWPSDVVEFGAI-NITGFRIV 288
            |.|.||..          ..||..       |..:||:.|  |:..|.|......: .:..||..
plant   240 IFVVHVNPDSGLNIFSVAKSLGMMGSGYVWITTDWLLTAL--DSMEPLDPRALDLLQGVVAFRHY 302

  Fly   289 DSNRRAVRDFHDSRKRLEPSGQSQSQNAGGPNSLPAISAQAALMYDAVFVLVEAFNRILRKKPDQ 353
            .......|.|....|.|......:|.:  |.||      .|...||:|:::..|.        |.
plant   303 TPESDNKRQFKGRWKNLRFKESLKSDD--GFNS------YALYAYDSVWLVARAL--------DV 351

  Fly   354 FRSNHLQRRSHGGSSSSSATGTNESSALLDCNTSKGWVTPWEQGEKISRVLRKVEIDGLSGEIRF 418
            |.|   |..:...|:..|...||:|...|    ||..:  :.:||:..:|:.::...||:|:|.|
plant   352 FFS---QGNTVTFSNDPSLRNTNDSGIKL----SKLHI--FNEGERFLQVILEMNYTGLTGQIEF 407

  Fly   419 DEDGRRINYTLHVVEMSVNSTLQQVAEWRDDAGLLPLHSHNYASSSRSASASTGDYDRNHTYIVS 483
            :.:..|||....::.:.....| :|..|.:..|..........|...:.||.  |...|......
plant   408 NSEKNRINPAYDILNIKSTGPL-RVGYWSNHTGFSVAPPETLYSKPSNTSAK--DQRLNEIIWPG 469

  Fly   484 SLLEEP------------------YLSLKQYTYGESLVGNDR----FEGYCKDLADMLAAQLGIK 526
            .:::.|                  .:|.|.|      ...|:    .:|:|.|:.: .|.|| :.
plant   470 EVIKPPRGWVFPENGKPLKIGVPNRVSYKNY------ASKDKNPLGVKGFCIDIFE-AAIQL-LP 526

  Fly   527 YEIR----LVQDGNYGAENQYAPGGWDGMVGELIRKEADIAISAMTITAERERVIDFSKPFMTLG 587
            |.:.    |..||....       .:|.::.|:.....|:|:..:||...|.:.:||::||:..|
plant   527 YPVPRTYILYGDGKKNP-------SYDNLISEVAANIFDVAVGDVTIITNRTKFVDFTQPFIESG 584

  Fly   588 ISIMIK-KPVKQTPGVFSFLNPLSQEIWISVILSYVGVSFVLYFVTRFPPYEWRIVRRPQADSTA 651
            :.::.. |..|.:|  :|||.|.:.|:|......::.|..|::.:......|:|
plant   585 LVVVAPVKGAKSSP--WSFLKPFTIEMWAVTGALFLFVGAVIWILEHRFNEEFR----------- 636

  Fly   652 QQPPGIIGGATLSEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGCDITPPSIAGRIAAAVWWFFT 716
                                 .||.. .::..||:|.:.......:.| .|..||....||.|..
plant   637 ---------------------GPPRR-QIITVFWFSFSTMFFSHRENT-VSTLGRFVLLVWLFVV 678

  Fly   717 IILISSYTANLAAFLTVERMVAPIKTPEDLTMQTD---VNYGTLLYGSTWEFFRRSQIGLHNKMW 778
            :|:.|||||:|.:.|||:::.:.|:..:.|....:   |..||.    .|:|       |.|:
plant   679 LIINSSYTASLTSILTVQQLTSRIEGMDTLIASNEPIGVQDGTF----AWKF-------LVNE-- 730

  Fly   779 EYMNANQHHSVHTYDE-----GIRRVRQSKGKYALLVESPKNEYVNARPPCDTMKVGRNIDTKGF 838
              :|......:...||     .::|..:..|..|::.|.|..:.:.:...|....||:.....|:
plant   731 --LNIAPSRIIPLKDEEEYLSALQRGPRGGGVAAIVDELPYIKALLSNSNCKFRTVGQEFTRTGW 793

  Fly   839 GVATPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFDKTECNLDQETSTPN-ELSLSNVAGIYYI 902
            |.|....|||...::.|:|.|.|.|:|.:||.||.....||.: |.:.|.| ::|:.:..|::
plant   794 GFAFQRDSPLAVDMSTAILQLAEEGKLEKIRKKWLTYDHECTM-QISDTENYQISVQSFWGLF-- 855

  Fly   903 LIGGLLLAVIVAIMEFFC 920
            ||.|::..:.:.:   ||
plant   856 LICGVVWFIALTL---FC 870

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375	99/456 (22%)
		ANF_receptor	53..434	CDD:279440	90/419 (21%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	99/436 (23%)
		Lig_chan	612..907	CDD:278489	73/303 (24%)
GLR3.5	NP_001324013.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	169	1.000	Inparanoid score	I1556
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.870