Protein Alignment GluRIA and GLR2.8

DIOPT Version :10

• Sequence 1: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: NP_001324459.1
• Gene: GLR2.8 / 817459
• AraportID: AT2G29110
• Length: 948
• Species: Arabidopsis thaliana
• Alignment Length: 1031
• Identity: 206/1031 - (19%)
• Similarity: 368/1031 - (35%)
• Gaps: 310/1031 - (30%)

  Fly     7 FLAYLHFICASSIFWPEFSSAQQQQQTVSLTEKIPLGAIFEQGTDDVQSAF-KYAMLNHNLNVS- 69
            ||:|  |:|...:.  |....|.|      ..:|.:|.:.     |:.:.| |..:.:.||.:|
plant    11 FLSY--FVCLFLLL--EVGLGQNQ------ISEIKVGVVL-----DLNTTFSKICLTSINLALSD 60

  Fly    70 ------SRRFELQAYV-----DVINTADAFKLSRLICNQFSRGVYSMLGAVSPDSFDTLHSYSNT 123
                  :.|..|..:|     |.:. |.|..|. ||.|:   .|.:::|.:.......:...:|.
plant    61 FYKDHPNYRTRLALHVRDSMKDTVQ-ASAAALD-LIQNE---QVSAIIGPIDSMQAKFMIKLANK 120

  Fly   124 FQMPFVTPWFPEKVLAPSSGLLDFAISMRPDYH-----------QAIIDTIQYYGWQSII----- 172
            .|:|.::       .:.:|.||   .|::.||.           :||....:.:||:|::
plant   121 TQVPTIS-------FSATSPLL---TSIKSDYFVRGTIDDSYQVKAIAAIFESFGWRSVVAIYVD 175

  Fly   173 ---------YLYD---------------SHDGLLRLQQIYQELKPGNETFRVQMVKRIANVTMAI 213
                     ||:|               ::|..: |:::|:.:......|.|.|..|:|:
plant   176 NELGEGIMPYLFDALQDVQVDRSVIPSEANDDQI-LKELYKLMTRQTRVFVVHMASRLAS----- 234

  Fly   214 EFLHTLEDLGRFSKKRIVLDCPAEMAKEIIVQHVRDIKLGRRTYHYLL-SGLVMDNHWPSDVVEF 277
                                        .|.:...:|.:....|.:|: :|:   .|....:...
plant   235 ----------------------------RIFEKATEIGMMEEGYVWLMTNGM---THMMRHIHHG 268

  Fly   278 GAIN----ITGFRIVDSNRRAVRDFHDSRKRLEPSGQSQSQNAGGPNSLPAISAQAALMYDAVFV 338
            .::|    :.|.|......:.:.||     ||......:.:|....:.|......|   ||:...
plant   269 RSLNTIDGVLGVRSHVPKSKGLEDF-----RLRWKRNFKKENPWLRDDLSIFGLWA---YDSTTA 325

  Fly   339 LVEAFNRILRKKPDQFRSNHLQRRSHGGSSSSSATGTNESSALLDCNTSKGWVTPWEQGEKISRV 403
            |..|   :.:.....|..|:    :.|.|::.:..||...|               ..|..:...
plant   326 LAMA---VEKTNISSFPYNN----ASGSSNNMTDLGTLHVS---------------RYGPSLLEA 368

  Fly   404 LRKVEIDGLSGEIRFDEDGRRINYTLHVVEMSVNSTLQQVAEWRDDAGLLPLHSHNYAS------ 462
            |.::..:||:|  ||:...|::......:...|.:..:.|..|....||:.::|:...|
plant   369 LSEIRFNGLAG--RFNLIDRQLESPKFEIINFVGNEERIVGFWTPSNGLVNVNSNKTTSFTGERF 431

  Fly   463 -----SSRSASASTG----------------------------DYDRNHT----YIV----SSLL 486
                 ..:|.....|                            |...|.|    |.:    ::|.
plant   432 GPLIWPGKSTIVPKGWEIPTNGKKIKVGVPVKKGFFNFVEVITDPITNITTPKGYAIDIFEAALK 496

  Fly   487 EEPYLSLKQYTYGESLVGNDRFEGYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAPGGWDGM 551
            :.||..:.||.         |||....|..|::                 |..:|    |..|.:
plant   497 KLPYSVIPQYY---------RFESPDDDYDDLV-----------------YKVDN----GTLDAV 531

  Fly   552 VGELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPLSQEIWIS 616
            ||:            :||||.|....||:.|:...|:|:|:.....:....:.||.|...::|::
plant   532 VGD------------VTITAYRSLYADFTLPYTESGVSMMVPVRDNENKNTWVFLKPWGLDLWVT 584

  Fly   617 VILSYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPNEFTML 681
            ....:|.:.||:          |....|...|...                      ||:. .:.
plant   585 TACFFVLIGFVV----------WLFEHRVNTDFRG----------------------PPHH-QIG 616

  Fly   682 NSFWYSLAAFMQQGCDITPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKTPEDL 746
            .|||:|.:..:....:....::| |....||.|..::|..||||||.:||||:|........:||
plant   617 TSFWFSFSTMVFAHREKVVSNLA-RFVVVVWCFVVLVLTQSYTANLTSFLTVQRFQPAAINVKDL 680

  Fly   747 TMQTDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYMNANQHHSV-------HTYDEGIRRVRQSKG 804
            ....|  |....:|:..:.|...:....:|:..:.::.:.|::       ..:|| :..:|....
plant   681 IKNGD--YVGYQHGAFVKDFLIKEGFNVSKLKPFGSSEECHALLSNGSISAAFDE-VAYLRAILS 742

  Fly   805 KYALLVESPKNEYVNARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIR 869
            :|.       ::|....|   |.|      |.|||.|.|..|||...:::|:|.:.:..|:..|.
plant   743 QYC-------SKYAIVEP---TFK------TAGFGFAFPRNSPLTGDVSKAILNVTQGDEMQHIE 791

  Fly   870 NKWWFDKTECNLDQETSTPNELSLSNVAGIYYILIGGL--LLAVIVAIMEFFCRNK 923
            |||:..:.:|...:...:.|.|||.:..|::  ||.|:  .||:::.:..|...|:
plant   792 NKWFMKQNDCPDPKTALSSNRLSLRSFWGLF--LIAGIASFLALLIFVFLFLYENR 845

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..456	CDD:380603	84/472 (18%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	95/416 (23%)
		Lig_chan	610..906	CDD:459656	70/302 (23%)
GLR2.8	NP_001324459.1	PBP1_GABAb_receptor_plant	35..419	CDD:380645	84/472 (18%)
		GluR_Plant	454..795	CDD:270404	95/435 (22%)