DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIA and GLR2.9

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	NP_001325277.1	Gene:	GLR2.9 / 817458	AraportID:	AT2G29100	Length:	942	Species:	Arabidopsis thaliana

Alignment Length:	1014	Identity:	199/1014 - (19%)
Similarity:	366/1014 - (36%)	Gaps:	269/1014 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MHSRLKFLAYLHFICASSIFWPEFSSAQQQQQTVSLTEKIPLGAIFEQGTDDVQSAF-KYAMLNH 64
            |.:...||:|  |:|...:........|        |.:|.:|.:.     |:.:.| |..:.:.
plant     3 MKTNNTFLSY--FVCGFLLMGVGLGQNQ--------TSEIKVGVVL-----DLNTTFSKICLTSI 52

  Fly    65 NLNVSS---------RRFELQAYVDVINT--ADAFKLSRLICNQFSRGVYSMLGAVSPDSFDTLH 118
            .:.||.         .|..|.....:.:|  |.|..|..:...|.|    :::|.::....|.:.
plant    53 KMAVSDFYADHPNYLTRLTLHVRDSMEDTVQASAAALDLIKTEQVS----AIIGPINSMQADFMI 113

  Fly   119 SYSNTFQMPFVT-------------PWFPEKVLAPSSGLLDFAISMRPDYHQAIIDTIQYYGWQS 170
            ..:|..|:|.:|             |:|....:..||.:            :||....:::.|:.
plant   114 KLANKTQVPTITFSATSPLLTSIKSPYFVRATIDDSSQV------------RAIASIFKFFRWRR 166

  Fly   171 IIYLY-DSHDGLLRLQQIYQELKPGNETFRVQMVKRIANVTMAI--EFLHTLEDLGRFSKKRIVL 232
            ::.:| |:..|...:..::..|:...       |||......||  |....|..|.....:..|:
plant   167 VVAIYVDNEFGEGFMPFLFDALQDVE-------VKRSVIPPEAIDDEIQKELRKLMERQARVFVV 224

  Fly   233 DCPAEMAKEIIVQHVRDIKLGRRTYHYLL-SGLVMDNHWPSDVVEFGAIN-ITGFRIVDSNRRAV 295
            ...:.:|..:. |..|||.:....|.:|: :|:   .|....:....::| |.|...|.|:....
plant   225 HMESSLALRVF-QIARDIGMMEEGYVWLMTNGM---THMMRHINNGRSLNTIEGVLGVRSHVPKS 285

  Fly   296 RDFHDSRKRLEPSGQSQSQNAGGPNSLPAISAQAALMYDAVFVLVEAFNRILRKKPDQFRSNHLQ 360
            ::..|.|.|.:.:.:.::     |:....::..|...||::..|.:|..:
plant   286 KELGDFRLRWKRTFEKEN-----PSMRDDLNVFALWAYDSITALAKAVEK--------------- 330

  Fly   361 RRSHGGSSSSSATGTNESSALLDCNTSKGWVTPWEQGEKISRVLRKVEIDGLSGEIRFDEDGRRI 425
                   :::.:...:..|.|....|..|.|.....|..:.:...:|..:||:||.:. .||:..
plant   331 -------ANTKSLWYDNGSTLSKNRTDLGNVGVSLYGPSLQKAFSEVRFNGLAGEFKL-IDGQLQ 387

  Fly   426 NYTLHVVEMSVNSTLQQVAEWRDDAGLLPLHSHN--------YASSSR---------------SA 467
            :....::.. |.:..:.:..|....||:...|.|        :...|:               ..
plant   388 SPKFEIINF-VGNEERIIGFWTPRDGLMDATSSNKKTLGPVIWPGKSKIVPKGWEIPGKKLRVGV 451

  Fly   468 SASTGDYD------------RNHT-YIV----SSLLEEPYLSLKQYTYGESLVGNDRFEGYCKDL 515
            ....|.:|            :..| |.:    ::|.|.|||.:.:|...||
plant   452 PMKKGFFDFVKVTINPITNKKTPTGYAIEIFEAALKELPYLVIPEYVSFES-------------- 502

  Fly   516 ADMLAAQLGIKYEIRLVQDGNYGAENQYAPGGWDGMVGELIRKEADIAISAMTITAERERVIDFS 580
                                         |..::.:|.::..|..|..:..:||||.|....||:
plant   503 -----------------------------PNNYNNLVYQVYDKTWDAVVGDITITANRSLYADFT 538

  Fly   581 KPFMTLGISIMIKKPVKQTPGVFSFLNPLSQEIWISVILSYVGVSFVLYFVTRFPPYEWRIVRRP 645
            .||...|:|:|:.....:....:.||.|.|.|:|::....:|.:.||::.      :|.|:
plant   539 LPFTESGVSMMVPVRDNENKDTWVFLEPWSLELWVTTGCFFVFIGFVVWL------FEHRV---- 593

  Fly   646 QADSTAQQPPGIIGGATLSEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGCDITPPSIAGRIAAA 710
              ::..:.||                     ::.:..|.|:|.:..:....:....::| |....
plant   594 --NTDFRGPP---------------------QYQIGTSLWFSFSTMVFAHRENVVSNLA-RFVVV 634

  Fly   711 VWWFFTIILISSYTANLAAFLTVERMVAPIKTPEDLTMQTD-VNY------GTLLYGSTWEFFRR 768
            ||.|..::|..||||:|.:||||:.:...:....||....| |.|      ..:|.|
plant   635 VWCFVVLVLTQSYTASLTSFLTVQSLQPTVTNVNDLIKNRDCVGYQGGAFVKDILLG-------- 691

  Fly   769 SQIGLHNKMWEYMNANQHHSVHTYDEGIRRVRQSKGK--------------YALLVESPKNEYVN 819
              :|.|....:..:     |....|:.:     ||||              .|:|.:| .::||.
plant   692 --LGFHEDQLKPFD-----SAKDADDLL-----SKGKSKGIAAAFDEVAYLKAILSQS-CSKYVM 743

  Fly   820 ARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFDKTECNLDQE 884
            ..|   |.|.|      |||.|.|..|||....:.|:|.|.:|....:|.::|:..|.:|.....
plant   744 VEP---TFKTG------GFGFAFPKNSPLTGEFSRAILNLTQNNVTQQIEDRWFPKKNDCPDPMT 799

  Fly   885 TSTPNELSLSNVAGIYYILIGGLLLAVIVAIMEFFCRNK 923
            ..:.|.|:||:..|::.|....:..:::|.:..|...::
plant   800 ALSSNRLNLSSFLGLFLIAGTAISFSLLVFVALFLYEHR 838

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375	79/441 (18%)
		ANF_receptor	53..434	CDD:279440	74/410 (18%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	96/427 (22%)
		Lig_chan	612..907	CDD:278489	73/315 (23%)
GLR2.9	NP_001325277.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.920