DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIA and GLR2.2

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	NP_180048.1	Gene:	GLR2.2 / 817008	AraportID:	AT2G24720	Length:	920	Species:	Arabidopsis thaliana

Alignment Length:	1014	Identity:	212/1014 - (20%)
Similarity:	380/1014 - (37%)	Gaps:	259/1014 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 HSRL--KFLAYLHFICASSIFWPEFSSAQQQQQTVSLTEKIPLGAIFEQGTD--DVQSAFKYAML 62
            :|:|  :||....|.|..|      |..|...:|     ::.:|.:.:.||.  ||      |||
plant     3 NSKLFFRFLFLFFFFCLES------SRGQDNGKT-----QVNIGVVSDVGTSYPDV------AML 50

  Fly    63 NHNLNV----SSR-RFELQAYV-------DVINTADAFKLSRLICNQFSRGVYSMLG-------- 107
            ..|:::    ||| :|:.:..|       ||:..|.|  ...||.|   :.|.::||
plant    51 CINMSLADFYSSRPQFQTRLVVNVGDSKNDVVGAATA--AIDLIKN---KQVKAILGPWTSMQAH 110

  Fly   108 ---AVSPDSFDTLHSYSNTFQMPFVT----PWFPEKVLAPSSGLLDFAISMRPDYHQAIIDTIQY 165
               .:...|...:.|||.|  .|.:|    |:|.......||.:            .||...|:.
plant   111 FLIEIGQKSRVPVVSYSAT--SPSLTSLRSPYFFRATYEDSSQV------------HAIKAIIKL 161

  Fly   166 YGWQSIIYLYDSH---DGLL-----RLQQI-----YQELKPGNET---FRVQMVKRIANVTMAIE 214
            :||:.::.:|..:   :|::     .||.|     |:.:.|.|.|   ..|:::| :.|:...:.
plant   162 FGWREVVPVYIDNTFGEGIMPRLTDSLQDINVRIPYRSVIPLNATDQDISVELLK-MMNMPTRVF 225

  Fly   215 FLHTLEDLGRFSKKRIVLDCPAEMAKEIIVQHVRDIKLGRRTYHYLLSGLVMDNHWPSDVVEFGA 279
            .:|                ..:.:|..:.:: .:::.|.:..|.::|:..|||.        ..:
plant   226 IVH----------------MSSSLASTVFIK-AKELGLMKPGYVWILTNGVMDG--------LRS 265

  Fly   280 INITGFRIVDS---------NRRAVRDFHDSRKRLEPSGQSQSQNAGGPNSLPAISAQAALMYDA 335
            ||.||...::.         ..:.:..|....||..|   ....|..|..:..|.:|.|..:.||
plant   266 INETGIEAMEGVLGIKTYIPKSKDLETFRSRWKRRFP---QMELNVYGLWAYDATTALAMAIEDA 327

  Fly   336 VFVLVEAFNRILRKKPDQFRSNHLQRRSHGGSSSSSATGTNESSALLDCNTSKGWVTPWEQGEKI 400
                  ..|.:.....|.            |.:.|...|...|                :.|.|:
plant   328 ------GINNMTFSNVDT------------GKNVSELDGLGLS----------------QFGPKL 358

  Fly   401 SRVLRKVEIDGLSGEIRFDEDGRRINYTLHVVEMSVNSTLQQVAEWRDDAGLL------------ 453
            .:.:..|:..||:|:..| ..|:.......:|.| :.:..:.:..|.:..||:
plant   359 LQTVSTVQFKGLAGDFHF-VSGQLQPSVFEIVNM-IGTGERSIGFWTEGNGLVKKLDQEPRSIGT 421

  Fly   454 ----PLHSHNYASSSRSASASTG-DYDRNHTYIVSSLLEE-PYLSLKQYTYGESLVGNDRFEGYC 512
                |.|..:......:.|...| :...|...:...:.:. .:..|.:.| .:.:..:...:|:|
plant   422 LSTWPDHLKHIIWPGEAVSVPKGWEIPTNGKKLRIGVPKRIGFTDLVKVT-RDPITNSTVVKGFC 485

  Fly   513 KDL--ADMLAAQLGIKYEIRLVQDGNYGAENQYAPGGWDGMVGELIRKEADIAISAMTITAERER 575
            .|.  |.:.|....:.||.     ..:...|....|..:.:|.::...:.|..:...||.|.|..
plant   486 IDFFEAVIQAMPYDVSYEF-----FPFEKPNGEPAGNHNDLVHQVYLGQFDAVVGDTTILANRSS 545

  Fly   576 VIDFSKPFMTLGISIMI--KKPVKQTPGVFSFLNPLSQEIWISVILSY--VGVSFVLYFVTRFPP 636
            .:||:.|||..|:.:::  |..||:..  ||||.|||.|:|::.::.:  ||:|.
plant   546 FVDFTLPFMKSGVGLIVPLKDEVKRDK--FSFLKPLSIELWLTTLVFFFLVGISV---------- 598

  Fly   637 YEWRIVRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGCDITPP 701
              |.:..|..:|...                       |..:.....||::.:..:     ..|.
plant   599 --WTLEHRVNSDFRG-----------------------PANYQASTIFWFAFSTMV-----FAPR 633

  Fly   702 ----SIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKTPEDLTMQTDVNYGTLLYGST 762
                |...|.....|:|..::|..||||:||:.||.:::...|.:...|          |..|.|
plant   634 ERVLSFGARSLVVTWYFVLLVLTQSYTASLASLLTSQQLNPTITSMSSL----------LHRGET 688

  Fly   763 WEFFRRSQI--GLHNKMWEYMNANQHHSVHTYDEGIRRVRQSKGKYALLVESPKNEYVN--ARPP 823
            ..:.|.|.|  .|:...:...:.....:....||.:::..::.|..|..:.:|   ||.  ....
plant   689 VGYQRTSFILGKLNETGFPQSSLVPFDTAEECDELLKKGPKNGGVAAAFLGTP---YVRLFLGQY 750

  Fly   824 CDTMKVGR---NIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFDKTECNLDQET 885
            |:|.|:..   |:|  |||...||||||...::.|:|.:.|:.:.:.:.:.|:..|.:...|..|
plant   751 CNTYKMVEEPFNVD--GFGFVFPIGSPLVADVSRAILKVAESPKAVELEHAWFKKKEQSCPDPVT 813

  Fly   886 ---STPNELSLSNVAGIYYILIGGLLLAVIVAIMEF-FC 920
               |.|...::....|.::.|...:.:..::|:.:| ||
plant   814 NPDSNPTVTAIQLGVGSFWFLFLVVFVVCVLALGKFTFC 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375	93/465 (20%)
		ANF_receptor	53..434	CDD:279440	86/432 (20%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	94/419 (22%)
		Lig_chan	612..907	CDD:278489	66/310 (21%)
GLR2.2	NP_180048.1	PBP1_GABAb_receptor	33..412	CDD:107361	94/468 (20%)
		ANF_receptor	47..392	CDD:279440	87/434 (20%)
		HisJ	438..>587	CDD:223904	38/156 (24%)
		GluR_Plant	452..801	CDD:270404	91/411 (22%)
		Lig_chan	582..819	CDD:278489	63/291 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.920