DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIA and GLR2

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	NP_001318239.1	Gene:	GLR2 / 816231	AraportID:	AT2G17260	Length:	925	Species:	Arabidopsis thaliana

Alignment Length:	985	Identity:	201/985 - (20%)
Similarity:	389/985 - (39%)	Gaps:	232/985 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 IPLGAIFEQGTDDVQSAFKYAMLNHNLNVSSRRFELQAYVDVINTADAF----KLSRLICNQFSR 100
            |.:||||...|          |.....|::.:..|     :.:|:..:|    || |::.|...|
plant    34 IKVGAIFGLNT----------MYGETANIAFKAAE-----EDVNSDPSFLGGSKL-RILMNDAKR 82

  Fly   101 -GVYSMLGA-----------VSPDSFDTLHSYS---NTFQMPFVTPWFPEKVLAPSSGLLDFAIS 150
             |..|::||           :.|.:....|..|   |...:|.::....:..|:|..  ..|.:.
plant    83 SGFLSIMGALQFMETDVVAIIGPQTSIMAHVLSHLANELTVPMLSFTALDPTLSPLQ--FPFFVQ 145

  Fly   151 MRPD---YHQAIIDTIQYYGWQSIIYLY----DSHDGLLRLQQIYQELKPGNETFRVQMVKRIAN 208
            ..|.   ..:||.:.|.||||..::.||    :|.:|:..|....:| :....:::..:...:.
plant   146 TAPSDLFLMRAIAEMITYYGWSDVVALYNDDDNSRNGVTALGDELEE-RRCKISYKAVLPLDVV- 208

  Fly   209 VTMAIEFLHTLEDLGRFSKKRIVLDCPAEMAKEIIVQHVRDIKLGRRTYHYL------LSGLVMD 267
            :|..:|.:..|..:.....:.||::......|.|..:..|   ||.....|:      ||. |:|
plant   209 ITSPVEIIEELIKIRGMESRVIVVNTFPNTGKMIFKEAER---LGMMEKGYVWIATTWLSS-VLD 269

  Fly   268 NHWPSDVVEFGAINITGFRIVDSNRRAVRDFHDSRKRLEPSGQSQSQNAGGPNSLPAISAQAALM 332
            ::.|.|......:........||.::  |||           .::.:|....|....::......
plant   270 SNLPLDTKLVNGVLTLRLHTPDSRKK--RDF-----------AARWKNKLSNNKTIGLNVYGLYA 321

  Fly   333 YDAVFVLVEAFNRILRKKPDQFRSNHLQRRSHGGS---SSSSATGTNESSALLDCNTSKGWVTPW 394
            ||.|:::..|...:|..               ||:   |:.:..|:.:..||   |.|.  ::.:
plant   322 YDTVWIIARAVKTLLEA---------------GGNLSFSNDAKLGSLKGEAL---NLSA--LSRF 366

  Fly   395 EQGEKISRVLRKVEIDGLSGEIRFDEDGRRINYTLHVVEMSVNSTLQQVAEWRDDAGLLPLHSHN 459
            :||.::...:...::.||:|.::|..|...:..:..::.: |:..:.|:..|.:.:||..:...:
plant   367 DQGSQLLDYIVHTKMSGLTGPVQFHPDRSMLQPSYDIINL-VDDRVHQIGYWSNYSGLSIVPPES 430

  Fly   460 YASSSRSASASTGDYDRNHTYIV-----SSLLEEPYL----------------SLKQYTYGESLV 503
            :.|...:.|:|     ..|...|     :|:....::                |.|.:.   |.|
plant   431 FYSKPPNRSSS-----NQHLNSVTWPGGTSVTPRGWIFRNNGRRLRIGVPDRASFKDFV---SRV 487

  Fly   504 --GNDRFEGYCKDLADMLAAQLG--IKYEIRLVQDG----NYGAENQYAPGGWDGMVGELIRK-- 558
              .:::.:|||.|:.:.....|.  :.:|.....||    ||               .||:.|
plant   488 NGSSNKVQGYCIDVFEAAVKLLSYPVPHEFIFFGDGLTNPNY---------------NELVNKVT 537

  Fly   559 ---EADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPLSQEIWISVILS 620
               :.|..:..:.|..:|.|::||::|::..|: :::....:.....::||.|.:..:|......
plant   538 TGVDFDAVVGDIAIVTKRTRIVDFTQPYIESGL-VVVAPVTRLNENPWAFLRPFTLPMWAVTASF 601

  Fly   621 YVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPNEFTMLNSFW 685
            :|.|...::.:      |.||      :...:.||                     ...::...|
plant   602 FVIVGAAIWIL------EHRI------NDEFRGPP---------------------RRQIITILW 633

  Fly   686 YSLAAFMQQGCDITPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKTPEDLTMQT 750
            ::.:.......: |..|..||:...:|.|..:|:.|||||:|.:.|||:::.:|||..:.|...|
plant   634 FTFSTMFFSHRE-TTVSTLGRMVLLIWLFVVLIITSSYTASLTSILTVQQLNSPIKGVDTLISST 697

  Fly   751 DVNYGTLLY--GSTWEFFRRSQIGLHNKMW-------EYMNANQHHSVHTYDEGIRRVRQSKGKY 806
                |.:.:  ||..|.:...::.:.:...       ||.||.|:.:|                .
plant   698 ----GRIGFQVGSFAENYMTDELNIASSRLVPLASPEEYANALQNGTV----------------A 742

  Fly   807 ALLVESPKNEYVN--ARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIR 869
            |::.|.|   |::  ....|.....|:.....|:|.|.|..|||...::.|:|.|.|.|||.:|.
plant   743 AIVDERP---YIDLFLSDYCKFAIRGQEFTRCGWGFAFPRDSPLAVDMSTAILGLSETGELQKIH 804

  Fly   870 NKWWFDKTECNL--DQETSTPNELSLSNVAGIYYILIGGLLLAVIV---AIMEFFCRNKTPQ--- 926
            :: |..|:.|:.  ..::....:|::.:..|::.::....|:|:.:   .|:..||:: ||:
plant   805 DR-WLSKSNCSSPHGSQSGDSEQLNVHSFWGMFLVVGIACLVALFIHFFKIIRDFCKD-TPEVVV 867

  Fly   927 ---LKSPGSN 933
               :.||.|:
plant   868 EEAIPSPKSS 877

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375	89/446 (20%)
		ANF_receptor	53..434	CDD:279440	80/415 (19%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	94/446 (21%)
		Lig_chan	612..907	CDD:278489	66/307 (21%)
GLR2	NP_001318239.1	PBP1_GABAb_receptor	35..424	CDD:107361	89/446 (20%)
		GluR_Plant	468..808	CDD:270404	89/416 (21%)
		Lig_chan	594..843	CDD:306551	66/306 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.820