DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIA and grik5

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	NP_001315085.1	Gene:	grik5 / 798791	ZFINID:	ZDB-GENE-070821-6	Length:	1067	Species:	Danio rerio

Alignment Length:	937	Identity:	303/937 - (32%)
Similarity:	472/937 - (50%)	Gaps:	137/937 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 YLHFICASSIFWPEFSSAQQQQQTVSLTEKIPLGAIFEQGTDDVQ-----SAFKYAMLNHNLNVS 69
            |..|:..:.:..|..|.:|     ..:...:.:.||.    ||..     .....|:...|:| |
Zfish    12 YFRFLLVTVVTMPPSSLSQ-----TPVLSSVRMAAIL----DDSSVCGRGERLALALARENIN-S 66

  Fly    70 SRRFELQAYVDVINTADAFKLSR--------LICNQFSRGVYSMLG-AVSPDSFDTLHSYSNTFQ 125
            ......:|.|:|    |.|:|.:        .:|....:||.|::| |.||.|...:.......:
Zfish    67 VMENPARARVEV----DIFELQKDSQYETTDTMCQILPKGVVSVIGPASSPASGSIVSHICGEKE 127

  Fly   126 MPFV------TPWFPEKVLAPSSGLLDFA-ISMRP---DYHQAIIDTIQYYGWQSIIYLYDSHDG 180
            :|.|      ||..|         .|.|| :::.|   |...||...::.:.:.|...:....:.
Zfish   128 IPHVKIGPEETPRLP---------YLRFASVTLYPSNEDLSLAIGSILRSFSYPSASLVCAKAEC 183

  Fly   181 LLRLQQIYQELKPGNETFRVQMVKRIANVTMAIEFLHTLEDLGRFSKKRIVLDCPAEMAKEIIVQ 245
            ||||:::.:......||..::|:....:.|      ..|:::.......|::|..|.:: .:|::
Zfish   184 LLRLEELIRRFLISRETLSIRMLDDNLDPT------PLLKEIRDDKIATIIIDANASIS-YLILK 241

  Fly   246 HVRDIKLGRRTYHYLLSGLVMDNHWPSDVVEFGAINITGFRIVDSNRRAVRDFHDSRKRLEPSGQ 310
            ...::.:....|.|:|:.:.....|..|:|:..: ||.||.:.::......:|..|.......|.
Zfish   242 KASELGMTSAFYKYILTTMDFPLLWLDDIVDEQS-NIVGFSMFNTTHPFYLEFIRSLNLSWREGC 305

  Fly   311 SQSQNAGGPNSLPAISAQAALMYDAVFVLVEAFNRILRKKPDQFRSNHLQRRSHGGSSSSSATGT 375
            ..:...|     ||:|  :||::|||.|:|.|...:.|                     |...|.
Zfish   306 DINPYPG-----PALS--SALLFDAVHVVVSAVQELNR---------------------SQEIGV 342

  Fly   376 NESSALLDCNTSKGWVTPWEQGEKISRVLRKVEIDGLSGEIRFDEDGRRINYTLHVVEMSVNSTL 440
            ..    |.|.:.:    .|:.|..:...||.||.|||:|.:.|:..|:|.|||||::|.. ....
Zfish   343 KP----LSCTSPQ----IWQHGTSLMNYLRMVEYDGLTGRVEFNSKGQRTNYTLHILEKH-RGGH 398

  Fly   441 QQVAEWRDDAGLLPLHSHNYASSSRSASASTGDYDRNHTYIVSSLLEEPYLSLKQYTYGESLVGN 505
            :::..|..:..||        .:|.|...:..:...|.:.|::::||.||: :::..|.| ..||
Zfish   399 KEIGIWYSNNTLL--------MNSTSLDINVSETLANKSLIITTILENPYV-MRKINYQE-FEGN 453

  Fly   506 DRFEGYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAPGGWDGMVGELIRKEADIAISAMTIT 570
            :::||:|.|:...|:..|...|.|:||.||.|||..  ..|.|.|||||||.::||:|::|.|||
Zfish   454 EQYEGFCVDMLRELSDILKFTYRIKLVDDGLYGAPE--PNGSWTGMVGELINRKADLAVAAFTIT 516

  Fly   571 AERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPLSQEIWISVILSYVGVSFVLYFVTRFP 635
            :|||:|||||||||||||||:.:..:.:.||.||||:|.|..:|:.::|:|:.||.||:...|..
Zfish   517 SEREKVIDFSKPFMTLGISILYRVHIGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLSARLS 581

  Fly   636 PYEWRIVRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGCDITP 700
            ||||   ..|.        |.:.....|.|          |::|:.||.|:.:..|||||.:|.|
Zfish   582 PYEW---YNPH--------PCLRERRDLLE----------NQYTLGNSLWFPVGGFMQQGSEIMP 625

  Fly   701 PSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKTPEDLTMQTDVNYGTLLYGSTWEF 765
            .:::.|..:.|||.||:|:||||||||||||||:||..||::|:||..||::.|||:..|||..|
Zfish   626 RALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPIESPDDLADQTNIQYGTIHGGSTMTF 690

  Fly   766 FRRSQIGLHNKMWEYMNANQHH-SVHTYDEGIRRVRQSKGKYALLVESPKNEY---VNARPPCDT 826
            |..|:...:.:||.||.:.|.. .|.:.:|||.||..|  |||.|:||..|||   :|    |:.
Zfish   691 FMNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVVNS--KYAFLLESTMNEYHRSLN----CNL 749

  Fly   827 MKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFDKTECNLDQETSTPNEL 891
            .::|..:||||:|:..|:|||.|..|:.|||.|:||..|..::.:|| :..:|. .:|......|
Zfish   750 TQIGGLLDTKGYGIGMPLGSPFRDELSLAVLQLQENNRLEILKRRWW-EGGKCP-KEEDHRAKGL 812

  Fly   892 SLSNVAGIYYILIGGLLLAVIVAIMEF 918
            .:.|:.||:.:||.||::||.||:|||
Zfish   813 GMENIGGIFVVLICGLIIAVFVAVMEF 839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375	99/435 (23%)
		ANF_receptor	53..434	CDD:279440	93/404 (23%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	178/405 (44%)
		Lig_chan	612..907	CDD:278489	119/298 (40%)
grik5	NP_001315085.1	PBP1_iGluR_Kainate_KA1_2	38..412	CDD:107389	101/444 (23%)
		ANF_receptor	55..392	CDD:279440	93/394 (24%)
		Periplasmic_Binding_Protein_Type_1	<313..383	CDD:299141	28/100 (28%)
		Periplasmic_Binding_Protein_Type_2	427..797	CDD:304360	178/401 (44%)
		Lig_chan	558..828	CDD:278489	119/298 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590948
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.750