Protein Alignment GluRIA and grik5

DIOPT Version :10

• Sequence 1: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: NP_001315085.1
• Gene: grik5 / 798791
• ZFINID: ZDB-GENE-070821-6
• Length: 1067
• Species: Danio rerio
• Alignment Length: 937
• Identity: 303/937 - (32%)
• Similarity: 472/937 - (50%)
• Gaps: 137/937 - (14%)

  Fly    10 YLHFICASSIFWPEFSSAQQQQQTVSLTEKIPLGAIFEQGTDDVQ-----SAFKYAMLNHNLNVS 69
            |..|:..:.:..|..|.:|     ..:...:.:.||.    ||..     .....|:...|:| |
Zfish    12 YFRFLLVTVVTMPPSSLSQ-----TPVLSSVRMAAIL----DDSSVCGRGERLALALARENIN-S 66

  Fly    70 SRRFELQAYVDVINTADAFKLSR--------LICNQFSRGVYSMLG-AVSPDSFDTLHSYSNTFQ 125
            ......:|.|:|    |.|:|.:        .:|....:||.|::| |.||.|...:.......:
Zfish    67 VMENPARARVEV----DIFELQKDSQYETTDTMCQILPKGVVSVIGPASSPASGSIVSHICGEKE 127

  Fly   126 MPFV------TPWFPEKVLAPSSGLLDFA-ISMRP---DYHQAIIDTIQYYGWQSIIYLYDSHDG 180
            :|.|      ||..|         .|.|| :::.|   |...||...::.:.:.|...:....:.
Zfish   128 IPHVKIGPEETPRLP---------YLRFASVTLYPSNEDLSLAIGSILRSFSYPSASLVCAKAEC 183

  Fly   181 LLRLQQIYQELKPGNETFRVQMVKRIANVTMAIEFLHTLEDLGRFSKKRIVLDCPAEMAKEIIVQ 245
            ||||:::.:......||..::|:....:.|      ..|:::.......|::|..|.:: .:|::
Zfish   184 LLRLEELIRRFLISRETLSIRMLDDNLDPT------PLLKEIRDDKIATIIIDANASIS-YLILK 241

  Fly   246 HVRDIKLGRRTYHYLLSGLVMDNHWPSDVVEFGAINITGFRIVDSNRRAVRDFHDSRKRLEPSGQ 310
            ...::.:....|.|:|:.:.....|..|:|:..: ||.||.:.::......:|..|.......|.
Zfish   242 KASELGMTSAFYKYILTTMDFPLLWLDDIVDEQS-NIVGFSMFNTTHPFYLEFIRSLNLSWREGC 305

  Fly   311 SQSQNAGGPNSLPAISAQAALMYDAVFVLVEAFNRILRKKPDQFRSNHLQRRSHGGSSSSSATGT 375
            ..:...|     ||:|  :||::|||.|:|.|...:.|                     |...|.
Zfish   306 DINPYPG-----PALS--SALLFDAVHVVVSAVQELNR---------------------SQEIGV 342

  Fly   376 NESSALLDCNTSKGWVTPWEQGEKISRVLRKVEIDGLSGEIRFDEDGRRINYTLHVVEMSVNSTL 440
            ..    |.|.:.:    .|:.|..:...||.||.|||:|.:.|:..|:|.|||||::|.. ....
Zfish   343 KP----LSCTSPQ----IWQHGTSLMNYLRMVEYDGLTGRVEFNSKGQRTNYTLHILEKH-RGGH 398

  Fly   441 QQVAEWRDDAGLLPLHSHNYASSSRSASASTGDYDRNHTYIVSSLLEEPYLSLKQYTYGESLVGN 505
            :::..|..:..||        .:|.|...:..:...|.:.|::::||.||: :::..|.| ..||
Zfish   399 KEIGIWYSNNTLL--------MNSTSLDINVSETLANKSLIITTILENPYV-MRKINYQE-FEGN 453

  Fly   506 DRFEGYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAPGGWDGMVGELIRKEADIAISAMTIT 570
            :::||:|.|:...|:..|...|.|:||.||.|||..  ..|.|.|||||||.::||:|::|.|||
Zfish   454 EQYEGFCVDMLRELSDILKFTYRIKLVDDGLYGAPE--PNGSWTGMVGELINRKADLAVAAFTIT 516

  Fly   571 AERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPLSQEIWISVILSYVGVSFVLYFVTRFP 635
            :|||:|||||||||||||||:.:..:.:.||.||||:|.|..:|:.::|:|:.||.||:...|..
Zfish   517 SEREKVIDFSKPFMTLGISILYRVHIGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLSARLS 581

  Fly   636 PYEWRIVRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGCDITP 700
            ||||   ..|.        |.:.....|.|          |::|:.||.|:.:..|||||.:|.|
Zfish   582 PYEW---YNPH--------PCLRERRDLLE----------NQYTLGNSLWFPVGGFMQQGSEIMP 625

  Fly   701 PSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKTPEDLTMQTDVNYGTLLYGSTWEF 765
            .:::.|..:.|||.||:|:||||||||||||||:||..||::|:||..||::.|||:..|||..|
Zfish   626 RALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPIESPDDLADQTNIQYGTIHGGSTMTF 690

  Fly   766 FRRSQIGLHNKMWEYMNANQHH-SVHTYDEGIRRVRQSKGKYALLVESPKNEY---VNARPPCDT 826
            |..|:...:.:||.||.:.|.. .|.:.:|||.||..|  |||.|:||..|||   :|    |:.
Zfish   691 FMNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVVNS--KYAFLLESTMNEYHRSLN----CNL 749

  Fly   827 MKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFDKTECNLDQETSTPNEL 891
            .::|..:||||:|:..|:|||.|..|:.|||.|:||..|..::.:|| :..:|. .:|......|
Zfish   750 TQIGGLLDTKGYGIGMPLGSPFRDELSLAVLQLQENNRLEILKRRWW-EGGKCP-KEEDHRAKGL 812

  Fly   892 SLSNVAGIYYILIGGLLLAVIVAIMEF 918
            .:.|:.||:.:||.||::||.||:|||
Zfish   813 GMENIGGIFVVLICGLIIAVFVAVMEF 839

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..456	CDD:380603	101/438 (23%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	178/405 (44%)
		Lig_chan	610..906	CDD:459656	120/299 (40%)
grik5	NP_001315085.1	PBP1_iGluR_Kainate_KA1_2	36..414	CDD:380616	101/448 (23%)
		Periplasmic_Binding_Protein_Type_2	427..797	CDD:473866	178/401 (44%)