DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIA and Grid2

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	NP_077355.2	Gene:	Grid2 / 79220	RGDID:	68368	Length:	1007	Species:	Rattus norvegicus

Alignment Length:	947	Identity:	233/947 - (24%)
Similarity:	433/947 - (45%)	Gaps:	165/947 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 IPLGAIFEQGTDDVQSAFKYAM--LNHNLNVSSRRFELQAYVDVINTADAFKLSRLICNQFSRGV 102
            |.:||||::........|:.|:  ||.|..:.... ::...|..::..:.|:..:..|...::|:
  Rat    27 IHIGAIFDESAKKDDEVFRTAVGDLNQNEEILQTE-KITFSVTFVDGNNPFQAVQEACELMNQGI 90

  Fly   103 YSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLA--PSSGL--------LDFAISMRPDYH- 156
            .:::.::...|..:|.|.::...:|.:   |.::..|  |.||.        .|:.:|:||..:
  Rat    91 LALVSSIGCTSAGSLQSLADAMHIPHL---FIQRSTAGTPRSGCGLTRSNRNDDYTLSVRPPVYL 152

  Fly   157 -QAIIDTIQYYGWQSIIYLYDSHDGLLRLQQIYQELKPGNETFRVQMVKRIAN--VTMAIEFLHT 218
             :.|:..:..|.||..|..|||...:..:|:...::........:|.|:...|  :|...:.:.
  Rat   153 NEVILRVVTEYAWQKFIIFYDSEYDIRGIQEFLDKVSQQGMDVALQKVENNINKMITTLFDTMR- 216

  Fly   219 LEDLGRF--SKKRIVLDCPAEMAKEIIVQHVRDIKLGRRTYHYLLSGLV-MDNHW--------PS 272
            :|:|.|:  :.:|.:|......||..|.:.|.             :.|| .|.||        ..
  Rat   217 IEELNRYRDTLRRAILVMNPATAKSFISEVVE-------------TNLVAFDCHWIIINEEINDV 268

  Fly   273 DVVEFGAINITGFRIV--------DSNRRAVRDFHDSRKRLEPSGQSQSQNAGGPNSLPAISAQA 329
            ||.|....:|....|:        :.::|..|..|.....|.......:||         :....
  Rat   269 DVQELVRRSIGRLTIIRQTFPVPQNISQRCFRGNHRISSTLCDPKDPFAQN---------MEISN 324

  Fly   330 ALMYDAVFVLVEAFNRILRKKPDQFRSNHLQRRSHGGSSSSSATGTNESSALLDC--NTSKGWVT 392
            ..:||.|.:|..||::.|.           .|:.|             |.|.|.|  ..||
  Rat   325 LYIYDTVLLLANAFHKKLE-----------DRKWH-------------SMASLSCIRKNSK---- 361

  Fly   393 PWEQGEKISRVLRKVEIDGLSGEIRFDEDGRRINYTLHVVEMSVNSTL----QQVAEWRDDAGLL 453
            ||:.|..:...::|..::||:|::.|.|:|...|....::..:....|    :::..|....||
  Rat   362 PWQGGRSMLETIKKGGVNGLTGDLEFGENGGNPNVHFEILGTNYGEELGRGVRKLGCWNPVTGL- 425

  Fly   454 PLHSHNYASSSRSASASTGDYDRNHTYI---VSSLLEEPYLSLKQYTYGESLVGNDRFEGYCKDL 515
                        :.|.:....:.|...:   |.::||||::.:.:...|:.    .:::|:..|:
  Rat   426 ------------NGSLTDKKLENNMRGVVLRVVTVLEEPFVMVSENVLGKP----KKYQGFSIDV 474

  Fly   516 ADMLAAQLGIKYEIRLVQDGNYGAENQYAPGGWDGMVGELIRKEADIAISAMTITAERERVIDFS 580
            .|.|:..||..|||.:..|..||:..:  .|.|:|:||||:.|.|||.|||:|||.:||.|:||:
  Rat   475 LDALSNYLGFNYEIYVAPDHKYGSPQE--DGTWNGLVGELVFKRADIGISALTITPDRENVVDFT 537

  Fly   581 KPFMTLGISIMIKKPVKQTPGVFSFLNPLSQEIWISVILSYVGVSFVLYFVTRFPPYEWRIVRRP 645
            ..:|...:.::::: .::|..:|:.|.|....:|..:..:.:.|..::|.:      .|
  Rat   538 TRYMDYSVGVLLRR-AEKTVDMFACLAPFDLSLWACIAGTVLLVGLLVYLL------NW------ 589

  Fly   646 QADSTAQQPPGIIGGATLSEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGCDITPPSIAGRIAAA 710
                  ..||.:..|:..|.             |:.||.|:...:|:|||.::...::|.|:...
  Rat   590 ------LNPPRLQMGSMTST-------------TLYNSMWFVYGSFVQQGGEVPYTTLATRMMMG 635

  Fly   711 VWWFFTIILISSYTANLAAFLTVERMVAPIKTPEDLTMQTDVNYGTLLYGSTWEFFRRSQI---- 771
            .||.|.:|:|||||||||||||:.|:.:.|::.:||:.|||:.|||:|..:.::..|...:
  Rat   636 AWWLFALIVISSYTANLAAFLTITRIESSIQSLQDLSKQTDIPYGTVLDSAVYQHVRMKGLNPFE 700

  Fly   772 --GLHNKMWEYMNAN--QHHSVHTYDEGIRRVRQSKGKYALLVESPKNEYVNAR-PPCDTMKVGR 831
              .::::||..:|.:  ..::|.....||::|:.  |.||.:.::...|||... |.|....||.
  Rat   701 RDSMYSQMWRMINRSNGSENNVLESQAGIQKVKY--GNYAFVWDAAVLEYVAINDPDCSFYTVGN 763

  Fly   832 NIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFDKTECNLDQETSTPNE---LSL 893
            .:..:|:|:|...|||.|...::.:|.|:::|::..:::|||....:|:|........:   |.:
  Rat   764 TVADRGYGIALQHGSPYRDVFSQRILELQQSGDMDILKHKWWPKNGQCDLYSSVDAKQKGGALDI 828

  Fly   894 SNVAGIYYILIGGLLLAVIVAIME-FFCRNKTPQLKS 929
            .::||::.||..|::|:.::|::| ::.|.|..::.|
  Rat   829 KSLAGVFCILAAGIVLSCLIAVLETWWSRRKGSRVPS 865

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375	93/452 (21%)
		ANF_receptor	53..434	CDD:279440	86/417 (21%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	123/413 (30%)
		Lig_chan	612..907	CDD:278489	84/306 (27%)
Grid2	NP_077355.2	Interaction with CBLN1 homotrimer. /evidence=ECO:0000250\|UniProtKB:O43424	24..345		72/355 (20%)
		Periplasmic_Binding_Protein_type1	28..429	CDD:415822	94/468 (20%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	121/405 (30%)
		Interaction with AP4M1. /evidence=ECO:0000269\|PubMed:14572453	921..991
		PDZ-binding. /evidence=ECO:0000250	1005..1007
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810