DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GluRIA and Ir7e

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	NP_001138176.1	Gene:	Ir7e / 7354417	FlyBaseID:	FBgn0259189	Length:	608	Species:	Drosophila melanogaster

Alignment Length:	464	Identity:	92/464 - (19%)
Similarity:	154/464 - (33%)	Gaps:	125/464 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   489 PYLSLKQYTYGESLVGNDRFEGYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAPGGWDGMVG 553
            |:|:|.: ...|.|..|..:||   .|...||.::.....:|.|.....           |..:.
  Fly   221 PFLTLDE-DQEEVLRVNGGYEG---RLLLALAEKMNFTIAVRKVHVNMR-----------DEALE 270

  Fly   554 ELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFL------------ 606
            .|.|.|.|:.:..:..|..|..|...|..:             .||..||..|
  Fly   271 MLRRDEVDLTLGGIRQTVARGMVATSSHNY-------------HQTREVFGVLASSYELSSFDIL 322

  Fly   607 -NPLSQEIWISVILSYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQQPPGIIGGATLSEPQAHV 670
             .|...:||:. ||..|.:|.::.                           :|.|..|.|
  Fly   323 FYPYRLQIWMG-ILGVVALSALIQ---------------------------LIVGRMLRE----- 354

  Fly   671 PPVPPNEFTMLNSFWYSL-AAFMQQGCDITPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVE 734
                    .|.:.||.:| ..|:.......|.|...|:...:...:|:|:.:.|...|...:...
  Fly   355 --------RMGSRFWLNLELVFVGMPLLECPRSHTARLYCVMLMMYTLIIRTIYQGLLYHLIRTH 411

  Fly   735 RMVAPIKTPEDLTMQTDVNYGTLLYGSTWEF-----------FRRSQIGLHNKMWEYMNAN---- 784
            ::....:|.|.|..:   |:..:|.....|.           ||..:.........::.||
  Fly   412 QLNRWPQTIESLVQK---NFTVVLTPIVQEVLDEIPSVQHMRFRLLEANSELDPLYFLEANHQLR 473

  Fly   785 QHHSVHTYDEGIRRVRQSKGKYALLVESPKNEYVNARPPCD------TMKVGRNIDTKGFGVATP 843
            ||.:....|..|...|.|..|.....|.....:....|. |      ||.:.::
  Fly   474 QHVTASALDIFIHFNRLSADKVHQRGEQGSGAHFEIVPE-DIISMQLTMYLAKH----------- 526

  Fly   844 IGSPLRKRLNEAVLTLKENGELLRIRNKWWFDKTECNLDQETSTPNELSLSNVAGIYYILIGGLL 908
              |.|..:|||.::.::..| ||.:.::|  :.:|..|..|.|. ..|....:..|:.:::.||:
  Fly   527 --SFLIDQLNEEIMWMRSVG-LLSVWSRW--ELSESYLRNEQSF-QVLGTMELYAIFLMVLVGLI 585

  Fly   909 LAVIVAIME 917
            :.::|.|:|
  Fly   586 VGLLVFILE 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375
		ANF_receptor	53..434	CDD:279440
		PBP2_iGluR_AMPA	477..879	CDD:270433	81/424 (19%)
		Lig_chan	612..907	CDD:278489	59/316 (19%)
Ir7e	NP_001138176.1	PBPb	218..>313	CDD:214497	27/119 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462557
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740