DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIA and Ir7d

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	NP_001138175.1	Gene:	Ir7d / 7354416	FlyBaseID:	FBgn0259190	Length:	594	Species:	Drosophila melanogaster

Alignment Length:	777	Identity:	135/777 - (17%)
Similarity:	236/777 - (30%)	Gaps:	316/777 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   245 QHVRDIKLGRRTYHYL----LSGLVMDNHWPSDVVEFGAINITGFRIVDSNRRAVRDFHDSRKRL 305
            ||:.:.:|..:....|    ::||.:.|        ||....|.:..:|            |.|:
  Fly    24 QHLLEEQLASQISATLQKIFINGLAVYN--------FGVFISTSYEEMD------------RDRV 68

  Fly   306 EPSGQSQSQNAGGPNSLPA----------ISAQ--AALMY----DAVFVLVEAFNR-------IL 347
            ....|..::|...||...|          |:||  ..|::    :....:.|..||       :|
  Fly    69 ILVHQVLNRNLYPPNFPVAVVLASKMNRKITAQVFTQLLFVQNAEQAIAIAEGVNRNGLCVIVLL 133

  Fly   348 RKKPD------------QFRSN----HLQRRSHGGSSSSSATGTNESSALLDCNTSKGWVTPWEQ 396
            ..:|:            |.|.|    .|..|.||..:.:....|..|     |::
  Fly   134 TSQPERPIMTKIFTYFMQERYNINVVILVPRLHGVQAFNVRPYTPTS-----CSS---------- 183

  Fly   397 GEKISRVLRKVEIDGLSGEIRFDEDGRRINYTLHVVEMSVNSTLQQVAEWRDDAGLLPLHSHNYA 461
                   |..||||...|:: :|...||:. .||...:||
  Fly   184 -------LEPVEIDIKDGDL-WDVFPRRLK-NLHGCPLSV------------------------- 214

  Fly   462 SSSRSASASTGDYDRNHTYIVSSLLEEPYLSLKQYTYGESLVGNDRFEGYCKDLADMLAAQLGIK 526
                               ||..:  .||:.: .:...:.:.|.|..:|.   |..::|.::  .
  Fly   215 -------------------IVWDI--PPYMRI-NWKSSDPMDGLDGLDGL---LLRIVARKM--N 252

  Fly   527 YEIRLVQDGNYG--AENQYAPGGWDGMVGELIRKEADIAISAMTITAERERVIDFSKPFMTLGIS 589
            :.::|:.:...|  ..:.:..|.:.|....|..:.|:|.|.....|.||...::.:.|:
  Fly   253 FTLKLIPNEPNGLIGGSSFMNGTFTGAYKMLRERRANITIGCAACTPERSTFLEATSPY------ 311

  Fly   590 IMIKKPVKQTPGVFSFLNPLSQEIWISVILSYVGVSFVLYFVTRFP--PYEWRIVRRPQADSTAQ 652
                                ||..:|.|:.:..|.|  :|.|..||  .|.|.::      ||..
  Fly   312 --------------------SQMSYIIVLQARGGYS--IYEVMLFPFEKYTWLLL------STIL 348

  Fly   653 QPPGIIGGATLSEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGCDITPPSIAGRIAAAVWWFFTI 717
            ....|:|                       |.|           .:..|.:||      |..:..
  Fly   349 GLHWIVG-----------------------SRW-----------RMPSPILAG------WMLWIF 373

  Fly   718 ILISSYTANLAAFLTVERMVAPIKTPEDLTMQTDVNYG----------------------TL--- 757
            ::.:||.|::..|:    ..:|:| |...|:...::.|                      ||
  Fly   374 VIRASYEASVFNFI----QNSPVK-PSPRTLDQALSGGFRFITDHASYRMTLKIPSFQGKTLISA 433

  Fly   758 ---------LYGSTWE---FFRRSQIGLHNKMWEYMNANQHHSVHTYDEGIRRVRQSKGKYALLV 810
                     |..:.|:   |..|:.:..|                     :.|.|:.:.:..:|.
  Fly   434 GQPVDVFDALLKAPWKTGAFTSRAFLADH---------------------LVRHRKHRNQLVILA 477

  Fly   811 ESPKNEYVNARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFD 875
            |                |:..|:....|    |.||.....:|:.:..::..|..........:|
  Fly   478 E----------------KIVDNMLCMYF----PHGSYFAWEINKLLFNMRSFGIFQHHSQILAWD 522

  Fly   876 KTECNLDQETSTPNEL--------------SLSNVAGIYYILIGGLLLAVIVAIMEFFCRNK 923
            ......|  |.||.:.              |:|.|......|:|.|.::::|..:|...|.:
  Fly   523 NLPTTTD--TDTPGKRIHSSTESVATGFAESMSFVVAALNCLMGALCISIVVFGLELLSRRR 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375	50/250 (20%)
		ANF_receptor	53..434	CDD:279440	48/231 (21%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	72/442 (16%)
		Lig_chan	612..907	CDD:278489	58/347 (17%)
Ir7d	NP_001138175.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462561
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740