DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GluRIA and si:ch211-251b21.1

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	NP_001138274.1	Gene:	si:ch211-251b21.1 / 571720	ZFINID:	ZDB-GENE-060809-5	Length:	458	Species:	Danio rerio

Alignment Length:	503	Identity:	158/503 - (31%)
Similarity:	262/503 - (52%)	Gaps:	81/503 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   482 VSSLLEEPYLSLKQYTYGESLVGNDRFEGYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAPG 546
            |:::.||||...|    |..|      ||:|.|:...::.:||.||::.||:||.||..:.  .|
Zfish    27 VTTIKEEPYAMSK----GSEL------EGFCIDMLSAISNKLGFKYDVHLVKDGRYGKTDD--SG 79

  Fly   547 GWDGMVGELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVF-SFLNPLS 610
            .|:||:||::|.|||||::.:|:||:||.|:|.|||||..|:|.:::|.:......| |.|...|
Zfish    80 NWNGMIGEVVRGEADIAVAPLTLTAQREAVVDMSKPFMQTGLSFIMRKDLGSDDSQFLSLLKLFS 144

  Fly   611 QEIWISVILSYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPP 675
            .|:|:.|:::|:..|..::.|:|..|.||   .:|:.|:
Zfish   145 TEMWMGVLVAYLLTSICIFLVSRISPCEW---EQPEKDN-------------------------- 180

  Fly   676 NEFTMLNSFWYSLAAFMQQGCDITPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPI 740
            |.||:.:||||::.|...||....|.:::||:..::||.|:::|::.|.|||:.:|..:.....|
Zfish   181 NSFTLSHSFWYTVGALTLQGAGPHPKALSGRVITSIWWIFSLVLLACYFANLSLWLHSDNQQLSI 245

  Fly   741 KTPEDLTMQTDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYMNANQHHSVHTYDEGIRRVRQSKGK 805
            ||.|||..|..:.|||:...|::.||:.|....:::::|::...|.:|::. .||.||.:  ||.
Zfish   246 KTFEDLANQNVIEYGTIKDSSSFNFFKNSNNPTYHRIYEHIKEAQSYSLNA-AEGFRRAQ--KGN 307

  Fly   806 YALLVESPKNEYVNARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRN 870
            ||.:.||...:...|| .|:..:....|..:|:.:|.|:||||.|.|:.|:|.|.|:|||...|:
Zfish   308 YAFIGESVSLDLAVAR-YCNLTRAPEIIGMRGYSIAAPLGSPLIKNLSVAILRLSESGELDYFRS 371

  Fly   871 KWWFDKTECNLDQETSTPNELSLSNVAGIYYILIGGLLLAVIVAIMEFFCRNKTPQLKSPGSNGS 935
            |||  .:.|........|  |..:::.|::.:|..||.|.:.:|:||...:::
Zfish   372 KWW--ASSCVAKDSKGAP--LKPASLKGVFLLLAFGLGLGIFLALMELAAKSR------------ 420

  Fly   936 AGGVPGMLASSTYQRDSLSDAIMHSQAKLAMQASSEYDERLVGVELAS 983
                  .:|:|             .|.......|:|..:|..|.|:|:
Zfish   421 ------KVANS-------------EQKSCCSVMSAELSQRFRGGEVAT 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375
		ANF_receptor	53..434	CDD:279440
		PBP2_iGluR_AMPA	477..879	CDD:270433	138/397 (35%)
		Lig_chan	612..907	CDD:278489	90/294 (31%)
si:ch211-251b21.1	NP_001138274.1	PBP2_iGluR_non_NMDA_like	25..375	CDD:270403	138/394 (35%)
si:ch211-251b21.1	NP_001138274.1	Lig_chan	146..396	CDD:278489	88/286 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810