Protein Alignment GluRIA and grin3ba

DIOPT Version :10

• Sequence 1: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: XP_021323058.1
• Gene: grin3ba / 566411
• ZFINID: ZDB-GENE-070912-354
• Length: 1118
• Species: Danio rerio
• Alignment Length: 1062
• Identity: 225/1062 - (21%)
• Similarity: 398/1062 - (37%)
• Gaps: 299/1062 - (28%)

  Fly     6 KFLAYLHF---ICASSIFWPEFSSAQQQQQTVSLTEKIPLGAIF-EQGTDDVQSAFKYAML---- 62
            :||||||.   :......:|.....|.......:...:.|||:. .:....:|.|...|::
Zfish     7 RFLAYLHVGLQVALQMFIYPCHLHPQPCHILARIGHTVRLGALLPTRQQSRIQGALNRALVHLRQ 71

  Fly    63 --------NHNLNVSSRRFELQAYVDVINTADAFKLSRLICNQF-SRGVYSMLGAVSPDSFDTL- 117
                    |.:|.|.||        :.:| .|...:.|.:|... .:||.::|  ..|.|.:.|
Zfish    72 SGNNFLPYNLSLEVLSR--------EPLN-GDPESMFRCVCQDIVVQGVSAVL--AFPQSHEELI 125

  Fly   118 --HSYSNTFQMPFVT------PW-----FPEKVLA--PSSGLLD--FAISMRPDYHQAIIDTIQY 165
              ...|:..::||::      |.     |..:::.  |.|||.|  .|:.:|.
Zfish   126 QVEFMSSFLEIPFISIIEQGEPLKTQNRFHLQMMTRMPPSGLSDLLLAVLLRG------------ 178

  Fly   166 YGWQ---SIIYLYDSHDGLL-RLQQIYQELKPGN-----------ETFRVQMVKRIANVTMAIEF 215
             |||   :.:.....:.|:| .|||      .|:           ||..:..::...:....:|.
Zfish   179 -GWQGGAATVCPGGGNTGMLEELQQ------RGHLGLDGAHWHLWETLNLSRLEENISEDKVMEL 236

  Fly   216 LHTLEDLGRFSKKRIVLDCPAEMAKEIIVQHVRDIKLGRRTYH--YLLSGLVMDNHWPSDVVEFG 278
            |..|  |.|         .|:..|..::: ...|.:......|  :.|||.:...||
Zfish   237 LSQL--LSR---------TPSAPASSVVL-FGSDPECTATVLHCAHQLSGTLPPMHW-------- 281

  Fly   279 AINITGFRIVDSNRRAVRDFHDSRKRLEPSGQSQSQNAGGPNSLPAISAQAALMYDAVFVLVEAF 343
               |.|:.:                              ..:||.:|.:...||         |:
Zfish   282 ---IMGYPL------------------------------SLDSLHSIGSPLGLM---------AY 304

  Fly   344 NRILRKKPDQFRSNHLQRRSHGGSSSSSATGTNESSALL----DCNTSKGWVTPWEQGEKISRVL 404
            ..:.||..:.:..:.||..   |.:..:||......||:    :|............|:.::|.|
Zfish   305 GEVNRKPLNFYIRDTLQLI---GRAVYAATMVRPDLALIQNMVNCFDKPNKHELPSSGQYLARFL 366

  Fly   405 RKVEIDGLSGEIRFDEDGRRI--NYTLHVVEMSVNSTLQ----QVAEWR------DDAGLLP--- 454
            ......||:|.:|.:....|:  :...|:..:..:...|    .||.|:      ::.||.|
Zfish   367 SNTSFTGLTGPVRVERSFSRVLTSQRFHIWSLQRDPLGQPSWVTVASWQSGRLELEEQGLWPGVT 431

  Fly   455 -------------------------------LHSHNYASS---SRSASASTG----DYDRNHTYI 481
                                           |..|.:..:   ........|    |...|::.:
Zfish   432 QHQREDGPGIRLGGRWQAGLPVAGSRLRVVTLVEHPFVFTREVDEEGQCPAGQLCLDPQTNNSEV 496

  Fly   482 VSSLLEEPYLSLKQYTYGESLVGNDR--FEGYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYA 544
            ::.|..|    |:| |...||..:.|  ..|||.||.:.||..:..::::.:|.||.|||   :.
Zfish   497 LNQLFRE----LEQ-TNSSSLPTDMRKCCYGYCIDLLEKLAEDMHFEFDLYIVGDGKYGA---WK 553

  Fly   545 PGGWDGMVGELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPL 609
            .|.|.|:||:|:...||:|:::.:|.:.|.|||||:.||.:..:.|:::......| :.:|:.||
Zfish   554 GGRWSGLVGDLLSGVADMAVTSFSINSARSRVIDFTSPFFSTSLGILVRSKDTAAP-IGAFMWPL 617

  Fly   610 SQEIWISVILSYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQQPPGIIGGATLSEPQAHVPPVP 674
            ...:|:.:   :|.:.....|:|.   |||            ..|.|                :.
Zfish   618 HWSMWVGI---FVALHITALFITL---YEW------------NSPFG----------------MT 648

  Fly   675 PNEFTMLNSFWYSLA-------AFMQQGCDITPPSIAGRIAAAVWWFFTIILISSYTANLAAFLT 732
            |:....:..|.||.|       .|.:.....||....||....:|..|.::::|||||||||.:.
Zfish   649 PHGRNRIRVFSYSSALNLCYAILFGRTVASKTPKCWTGRFLMNLWAIFCLLVLSSYTANLAAVMV 713

  Fly   733 VERMVAPIKTPEDLTMQTDV---------NYGTLLYGSTWEFFRRSQIGLHNKMWEYMNANQHHS 788
            .|      ||.|:::...||         .:||:...|..::.::|...:|    |||   :..:
Zfish   714 GE------KTFEEVSGIHDVKLHHPSLGFRFGTVRESSAEDYVKKSFPEMH----EYM---RRFN 765

  Fly   789 VHTYDEGIRRVRQSKGKY-ALLVESPKNEY-VNARPPCDTMKVGRNIDTKGFGVATPIGSPLRKR 851
            ..|..:|:..::....:. |.:::....:| |:....|..:.||:....:|:|:..|..|||.:.
Zfish   766 KPTTPDGVSTLKTDPPQLDAFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPQNSPLTRN 830

  Fly   852 LNEAVLTLKENGELLRIRNKWW---------FDKTECNLDQETSTPNELSLSNVAGIYYILIGGL 907
            ::|.|...|.:|.:..:.:||:         |..||         ..::.:.:.:|::.:|..|:
Zfish   831 VSEYVSRYKSDGYMDMLHDKWYKVVPCGKRVFAVTE---------TLQMGIQHFSGLFVLLCVGV 886

  Fly   908 LLAVIVAIMEF-FCRNKTPQLK 928
            ..|::..:.|. |.|...|.|:
Zfish   887 AGALLTLLGEHAFFRFILPHLR 908

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..456	CDD:380603	92/513 (18%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	111/430 (26%)
		Lig_chan	610..906	CDD:459656	69/322 (21%)
grin3ba	XP_021323058.1	Periplasmic_Binding_Protein_type1	36..427	CDD:471960	90/485 (19%)
		PBP2_iGluR_NMDA_Nr3	457..852	CDD:270438	112/450 (25%)
		Lig_chan	618..885	CDD:459656	69/322 (21%)