DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIA and grin3a

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	XP_009303361.1	Gene:	grin3a / 564832	ZFINID:	ZDB-GENE-130530-780	Length:	1111	Species:	Danio rerio

Alignment Length:	921	Identity:	197/921 - (21%)
Similarity:	348/921 - (37%)	Gaps:	236/921 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 ADAFKLSRLICNQ-FSRGVYSMLG-AVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLAPSSGLLDF 147
            ||.....:.:|:. ..:||.:::. ..:.|....|...::|.|:|.::. ...:....:..||.|
Zfish   180 ADPVSFLQSVCHTVIVQGVSAIISFPQNRDELVKLEFIASTLQIPVISV-VQSEFQRQTQNLLHF 243

  Fly   148 AISMR-PDYHQA--IIDTIQYYGWQSIIYLYDSHDGLLRLQQI----YQELKPGNETFRVQMVKR 205
            .::|: |...||  |...:....|..:        .|:..||:    :..|...|..|.:..|.:
Zfish   244 QMAMQNPQTSQANLIFSLLSMNNWFDV--------SLVMCQQMNISDFVFLLHNNSKFHLGTVLK 300

  Fly   206 IANVTMAIEFLH-----TLEDLGRFSKKRIVLDCPAEMAKEIIVQHVRDIKLGRRTYHYLLS-GL 264
            |:..:.:....|     .||.:...:...:...|           .:|||   ||.:..:.. ||
Zfish   301 ISTNSSSKNDFHIFLQAQLESIKDSTSTLVTFGC-----------DIRDI---RRIFTTIAKFGL 351

  Fly   265 VM-DNHWPSDVVEFGAINITGFRIVDSNRRAVRDFHDSR--KRLEPSGQSQSQNAGGPNSLPAIS 326
            :: |.||           |.|               ||:  :.|...|......|.|....|::.
Zfish   352 ILPDYHW-----------IIG---------------DSQNVEELRTEGLPMGLLAHGRMGEPSLD 390

  Fly   327 --AQAALMYDAVFVLVEAFNRILRKKPDQFRSNHLQRRSHGGSSSSS-----ATGTNESSALLDC 384
              .|.||                          .|..|:.|.:::.|     ..||....|.|:.
Zfish   391 HYVQDAL--------------------------ELVARAVGSAATVSPQLALIPGTTNCLARLEA 429

  Fly   385 N--TSKGWVTPWEQGEKISRVLRKVEIDGLSGEIRFDEDGRRINYTLHVVEMSVNSTL-----QQ 442
            .  ||         |..:||.:.....|||||.|...|:...|:.:.|.:....:..:     .:
Zfish   430 KNLTS---------GTFLSRYMASTSFDGLSGCISVQEESTIISESHHFIWNLQHDPIGKPMWTR 485

  Fly   443 VAEWRD-----DAGLLPLHSHNYASSSRSASASTGDY---DRNHTYIVSSLLEEPY--------- 490
            :..|:.     |.|:.|         ::..|....|:   .|.|..:| :|:|.|:
Zfish   486 LGSWKHGKVVMDYGVWP---------NKRRSQPGADWRHSSRLHLRVV-TLVEHPFVFTRDVDDE 540

  Fly   491 -------LSLKQYTYGESLV---------GND----RFE----GYCKDLADMLAAQLGIKYEIRL 531
                   |.|...|...:|:         .||    .|:    |||.||.:.||..:|..:::.:
Zfish   541 GLCPAGQLCLDPLTNDTALLESLFQGLQGANDTVPLEFKKCCYGYCIDLLEKLAEDMGFDFDLYI 605

  Fly   532 VQDGNYGAENQYAPGGWDGMVGELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPV 596
            |.||.|||   |..|.|.|:||:|:...|.:|:::.:|.:.|.:||||:.||.:..:.|:::...
Zfish   606 VGDGKYGA---YKNGRWTGLVGDLMSGAAHLAVTSFSINSARSQVIDFTSPFFSTSLGILVRTRD 667

  Fly   597 KQTPGVFSFLNPLSQEIWISVILSYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQQPPGIIGGA 661
            ...| :.:|:.||...:|:.:   :|.:.....|:|.   |||:            .|.|
Zfish   668 TAAP-IGAFMWPLHWSMWLGI---FVSLHVTAVFLTL---YEWK------------SPFG----- 708

  Fly   662 TLSEPQAHVPPVPPNE---FTMLNSFWYSLAAFMQQGCDITPPSI-AGRIAAAVWWFFTIILISS 722
                    :.|...|.   |:..::.....|....:...|.||.. .||....:|..|.:..:|:
Zfish   709 --------MTPRGRNRDRVFSFSSALNVCYAILFGRTAAIKPPKCWTGRFLMNLWAIFCLFCLST 765

  Fly   723 YTANLAAFLTVERMVAPIKTPEDLTMQTD---------VNYGTLLYGSTWEFFRRSQIGLHNKMW 778
            |||||||.:..|      ||.|.|:...|         ..:||:...|..::.::|...:|
Zfish   766 YTANLAAVMVGE------KTYEQLSGIHDPKLHHPSQGFRFGTVRESSAEDYVKKSFPEMH---- 820

  Fly   779 EYMNANQHHSVHTYDEGIRRVRQSKGKY-ALLVESPKNEYVNARPPCDTMKVGRNIDTKGFGVAT 842
            |||   :.::..|..:||..::....|. |.:::....:|.     ....|...::...|:|:..
Zfish   821 EYM---RRYNAPTTPDGIDHLKDDPQKLDAFIMDKALLDYW-----AHADKXYISLLLTGYGIGL 877

  Fly   843 PIGSPLRKRLNEAVLTLKENGELLRIRNKWWFDKTECNLDQETSTPN-ELSLSNVAGIYYILIGG 906
            ...|||...::|.|...|.:|.:..:.:| |:....|.......|.. ::.:.:.:|::.:|..|
Zfish   878 KQNSPLTSNISELVSQYKSDGFMDMLHDK-WYKVVPCGKRSFAVTETLQMGIKHFSGLFVMLCVG 941

  Fly   907 LLLAVIVAIME 917
            :.|:::..:.|
Zfish   942 VALSLLTTLGE 952

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375	78/404 (19%)
		ANF_receptor	53..434	CDD:279440	75/375 (20%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	108/448 (24%)
		Lig_chan	612..907	CDD:278489	64/309 (21%)
grin3a	XP_009303361.1	Periplasmic_Binding_Protein_Type_1	36..502	CDD:299141	78/405 (19%)
		ANF_receptor	132..452	CDD:279440	69/355 (19%)
		PBP2_iGluR_NMDA_Nr3	518..908	CDD:270438	108/444 (24%)
		Lig_chan	682..941	CDD:278489	64/308 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590932
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740