DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment GluRIA and grin2aa

DIOPT Version :9

Sequence 1:NP_476855.1 Gene:GluRIA / 38742 FlyBaseID:FBgn0004619 Length:991 Species:Drosophila melanogaster
Sequence 2:XP_021329529.1 Gene:grin2aa / 563297 ZFINID:ZDB-GENE-070424-129 Length:1460 Species:Danio rerio


Alignment Length:954 Identity:214/954 - (22%)
Similarity:364/954 - (38%) Gaps:239/954 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    43 GAIFEQGTDDVQSAFKYAM-------LNHNLNVSSRRFELQAYVDVINTADAFKLSRLICNQFSR 100
            |.:|..|||  |.|....:       |...|.:......:.|..||.:|...|..|      ..:
Zfish    94 GVVFGDGTD--QEAIAQILDFISSQTLIPILGIHGGSSMIMADKDVKSTFFQFGAS------IQQ 150

  Fly   101 GVYSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLAPSSGLLDFAISMRPDYHQAIIDTI-- 163
            ....||..:  :.:| .|.:|      .||..||        |..||.         ||:.|.  
Zfish   151 EALLMLNIM--EEYD-WHVFS------IVTSKFP--------GYQDFI---------AILKTTVD 189

  Fly   164 -QYYGW--QSIIYLYDSHDGLLRLQQIYQELKPGNETFRVQMVKRIANVTMAIEFLHTLEDLGRF 225
             .:.||  |.||.| |:.||..|.|              :|:.|..:.|                
Zfish   190 NSFVGWDLQHIITL-DAVDGDSRTQ--------------IQLKKVQSPV---------------- 223

  Fly   226 SKKRIVLDCPAEMAKEIIVQHVRDIKLGRRTYHYLLSGLVMDNHWPS---DVVEFGAINITGFRI 287
                ::|.|..:.| ..|::..|.:.|....|.:::..|...|  |.   |....|.|:::    
Zfish   224 ----VLLYCSKDEA-AYILEEARSLGLTGFGYIWIVPSLTTGN--PEITPDTFPSGMISVS---- 277

  Fly   288 VDSNRRAVRDFHDSRKRLEPSGQSQSQNAGGPNSLPAISAQAALMYDAVFVLVEAFNRILRKKPD 352
                      :.|....||         |...:.|..|:..||.|       :|.|..|...|  
Zfish   278 ----------YDDWDYPLE---------ARVRDGLGIITTAAAAM-------LEEFGDIPEAK-- 314

  Fly   353 QFRSNHLQRRSHGGSSSSSATGTNESSALLDCNTSKGWVTPWEQGEKISRVLRKVEIDGLSGEIR 417
                             :|..|..|.:.|              ....:.:.:..|..||  .::.
Zfish   315 -----------------TSCYGQMEKTKL--------------PPSALHKYMMNVTWDG--KDLS 346

  Fly   418 FDEDGRRINYTLHVVEMSVNSTLQQVAEWRDDAGLLPLHSHNYASSSRSASASTGDYDRNHTYIV 482
            |.|||.:::..|.|:.::.:...:::.:|.:.:..|     .|....|..|....:.|.||..||
Zfish   347 FTEDGYQVHPKLVVIVLNKDREWEKMGKWENQSLTL-----KYPVWPR
FNSFGDAETDDNHLTIV 406

  Fly   483 SSLLEEPYLSL-----------------KQYTYGESLVGNDRF-----EGYCKDLADMLAAQLGI 525
             :|.|:|::.:                 :::....:..|...:     :|:|.|:...:|..:..
Zfish   407 -TLEEKPFVIVENVERLTGTCMRNSVPCRKHIKDNTTEGGGTYIKKCCKGFCIDILKKIARNVKF 470

  Fly   526 KYEIRLVQDGNYGAENQYAPGGWDGMVGELIRKEADIAISAMTITAERERVIDFSKPFMTLGISI 590
            .|::.||.:|.:|.:....   |:|||||::.|:|.:|:.::||..||..|||||.||:..|||:
Zfish   471 TYDLYLVTNGKHGKKINNV---WNGMVGEVVNKKAVMAVGSLTINEERSEVIDFSVPFVETGISV 532

  Fly   591 MIKKPVKQTPGVFSFLNPLSQEIWISVILSYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQQPP 655
            |:.:. ..|....:||.|.|..:|:.:.:       :|..||....:.:..:          .|.
Zfish   533 MVSRS-NGTVSPSAFLEPFSASVWVMMFV-------MLLLVTAMAVFMFEYI----------SPL 579

  Fly   656 GIIGGATLSE-PQAHVPPVPPNEFTMLNSFWYSLAAFMQQGCDI-TPPSIAGRIAAAVWWFFTII 718
            |.  ...|:: ...|.|     .|||..:.|............: .|.....:...:||.||.:|
Zfish   580 GF--NRNLAQGKDPHGP-----SFTMGKAVWLLWGLVFNNSVPVQNPKGTTSKFIVSVWAFFAVI 637

  Fly   719 LISSYTANLAAFLTVERMVAPIKTPEDLTMQTDVNY------GTLLYGSTWEFFRRSQIGLHNKM 777
            .::|||||||||:..|..|..:....|...|:..:|      ||:..|||....|::...:|..|
Zfish   638 FLASYTANLAAFMIQEEFVDQVTGLSDKKFQSPYSYSPPFRFGTVPNGSTERNIRKNYPDMHQYM 702

  Fly   778 WEYMNANQHHSVHTYDEGIRRVRQSKGKY-ALLVESPKNEYVNARPP-CDTMKVGRN--IDTKGF 838
            .:|.....:.::         |....||. |.:.::....|:..|.. |..:.:|..  ..|.|:
Zfish   703 VKYHQTGVNDAL---------VSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGYIFATTGY 758

  Fly   839 GVATPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFDKTECNLDQETSTPNELSLSNVAGIYYIL 903
            |:|...||..::.::.|:|.:..:||:..:..:|.  ...|:.::.....::|.:.|:||::|:|
Zfish   759 GIALQKGSLWKRPVDLAILAIIGDGEMEELEAQWL--TGICHNEKNEVMSSQLDVDNMAGVFYML 821

  Fly   904 IGGLLLAVIVAIME--FFCRNKTPQLKSPGSNGSAGGVPGMLAS 945
            ...:.|::|..:.|  |:.|.:.      ...|...|.||:|.|
Zfish   822 ATAMGLSLITFVWEHLFYWRLRY------CFTGVCSGTPGLLFS 859

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GluRIANP_476855.1 PBP1_iGluR_AMPA 41..453 CDD:107375 84/424 (20%)
ANF_receptor 53..434 CDD:279440 78/395 (20%)
PBP2_iGluR_AMPA 477..879 CDD:270433 107/435 (25%)
Lig_chan 612..907 CDD:278489 68/306 (22%)
grin2aaXP_021329529.1 PBP1_iGluR_NMDA_NR2 33..389 CDD:107373 86/436 (20%)
PBP2_iGluR_NMDA_Nr2 400..799 CDD:270436 108/438 (25%)
NMDAR2_C 836..1460 CDD:313729 8/30 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1052
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.810

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