Protein Alignment GluRIA and grik4

DIOPT Version :10

• Sequence 1: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: XP_021322088.1
• Gene: grik4 / 556582
• ZFINID: ZDB-GENE-070821-5
• Length: 965
• Species: Danio rerio
• Alignment Length: 887
• Identity: 298/887 - (33%)
• Similarity: 454/887 - (51%)
• Gaps: 116/887 - (13%)

  Fly    60 AMLNHNLNVS-SRRFELQAYVDVINTA-----------DAFKLSR--------LICNQFSRGVYS 104
            |:|:..:..| ..|..:....|.||.:           |.|:|.|        .:|...|:||.:
Zfish    29 AILDDPMECSRGERLAITLAKDSINRSSNRSTTGKLEVDIFELLRDSEYETGETMCQIMSKGVVA 93

  Fly   105 MLG-AVSPDSFDTLHSYSNTFQMPFVTPWFPE---KVLAPSSGLLDFAISMRP---DYHQAIIDT 162
            :|| :.||.|...:.:.....::|:|.. .||   ||..|....||    :||   |...|:...
Zfish    94 VLGPSASPASNSIISNICGEKEVPYVKV-APEDILKVQFPRFTTLD----LRPTNTDISMAVAGL 153

  Fly   163 IQYYGWQSIIYLYDSHDGLLRLQQIYQELKPGNETFRVQMVKRIANVTMAIEFLHTLEDLGRFSK 227
            :.::...:...:....|.||.|:.:.::.....||..|:|:....:.|      ..|:::.....
Zfish   154 LTFFNSSTSCLICAQADCLLNLEVLLRQFLISKETLSVRMLDDSQDPT------PLLKEIRDDKT 212

  Fly   228 KRIVLDCPAEMAKEIIVQHVRDIKLGRRTYHYLLSGLVMDNHWPSDVVEFGAINITGFRIVDSNR 292
            ..|::|..|.|: .:|::...::.:....|.|:|:.|........|:.: ..:||.||.:.:...
Zfish   213 ATIIVDANATMS-HVILERASELGMLSVYYTYILTSLEFSLLRLDDLAD-QRVNIVGFSVFNRTH 275

  Fly   293 RAVRDFHDSRKRLEPSGQSQSQNAGGPNSLPAISAQAALMYDAVFVLVEAFNRILRKKPDQFRSN 357
            ...:||..|..|........:..||.|.|       :||::|||..:|.|...:.|.:
Zfish   276 PFFQDFVLSLNRSWQENCDHAPFAGTPLS-------SALLFDAVHTVVAAVQELNRSQ------- 326

  Fly   358 HLQRRSHGGSSSSSATGTNESSALLDCNTSKGWVTPWEQGEKISRVLRKVEIDGLSGEIRFDEDG 422
                              |..:..|.|.:||    .||.|..:...||.||::||:|.|.|:..|
Zfish   327 ------------------NVGATQLSCKSSK----IWEHGTSLMNYLRMVELEGLTGHIEFNSKG 369

  Fly   423 RRINYTLHVVEMSVNSTLQQVAEWRDDAGLLPLHSHNYASSSRSASASTGDYDRNHTYIVSSLLE 487
            :|.||.|.:::.| ...|:|:.:|..:.||        :...:..|.:..|...|.|..::::||
Zfish   370 QRSNYALRIMQNS-RDGLRQIGQWHSEQGL--------SMERKLPSLNVTDTLFNTTLTITTILE 425

  Fly   488 EPYLSLKQYTYGESLVGNDRFEGYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAPGGWDGMV 552
            .||:.|:  ...:.|.||||:||:|.|:...||..|..||.||||.||.||...  |.|.|.|||
Zfish   426 NPYVMLR--ANHQELEGNDRYEGFCVDMLKELADILKFKYRIRLVGDGVYGVPG--ANGTWTGMV 486

  Fly   553 GELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPLSQEIWISV 617
            ||||.::||:|::|:|||||||:||||||||||||||||.:..:.:.||.||||:|.|..:|:.:
Zfish   487 GELISRKADLAVAALTITAEREKVIDFSKPFMTLGISIMYRVHIGRRPGYFSFLDPFSPGVWLFM 551

  Fly   618 ILSYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPNEFTMLN 682
            :|:|:.||.||:.|.|..||||   ..|.        |.:.|..:|.          .|::::.|
Zfish   552 LLAYLAVSCVLFLVARLTPYEW---YNPH--------PCLKGRCSLL----------INQYSLGN 595

  Fly   683 SFWYSLAAFMQQGCDITPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKTPEDLT 747
            |||:.:..|||||..|.|.:::.|..:.|||.||:|:||||||||||||||:||..||::.:||.
Zfish   596 SFWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPIESVDDLA 660

  Fly   748 MQTDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYMNANQHH-SVHTYDEGIRRVRQSKGKYALLVE 811
            .||.:.|||:..|||..||:.|:...:.:||.:|.:.|.. .|.:.:|||.||..|  .||.|:|
Zfish   661 DQTAIEYGTMHGGSTMTFFQNSRYQTYQRMWNFMYSKQPSVFVKSTEEGIARVLNS--NYAYLLE 723

  Fly   812 SPKNEYVNARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFDK 876
            |..|||...| .|:..::|..:||||:|:..|:||..|...:.|:|.|:|...|..::.||| |.
Zfish   724 STMNEYYRQR-NCNLTQIGGLLDTKGYGIGMPLGSVYRDEFDLAILRLQEENRLEILKRKWW-DG 786

  Fly   877 TECNLDQETSTPNELSLSNVAGIYYILIGGLLLAVIVAIMEF 918
            .:|. .:|......|.:.|:.||:.:|:.|||:|:.:|::||
Zfish   787 GKCP-KEEDHRAKGLGMENIGGIFVVLVCGLLVAIFMAVLEF 827

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..456	CDD:380603	101/422 (24%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	181/402 (45%)
		Lig_chan	610..906	CDD:459656	115/296 (39%)
grik4	XP_021322088.1	Periplasmic_Binding_Protein_type1	24..401	CDD:471960	101/429 (24%)
		PBP2_iGluR_kainate_KA1	425..785	CDD:270442	177/388 (46%)