DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIA and grik4

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	XP_021322087.1	Gene:	grik4 / 556582	ZFINID:	ZDB-GENE-070821-5	Length:	965	Species:	Danio rerio

Alignment Length:	887	Identity:	298/887 - (33%)
Similarity:	454/887 - (51%)	Gaps:	116/887 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 AMLNHNLNVS-SRRFELQAYVDVINTA-----------DAFKLSR--------LICNQFSRGVYS 104
            |:|:..:..| ..|..:....|.||.:           |.|:|.|        .:|...|:||.:
Zfish    29 AILDDPMECSRGERLAITLAKDSINRSSNRSTTGKLEVDIFELLRDSEYETGETMCQIMSKGVVA 93

  Fly   105 MLG-AVSPDSFDTLHSYSNTFQMPFVTPWFPE---KVLAPSSGLLDFAISMRP---DYHQAIIDT 162
            :|| :.||.|...:.:.....::|:|.. .||   ||..|....||    :||   |...|:...
Zfish    94 VLGPSASPASNSIISNICGEKEVPYVKV-APEDILKVQFPRFTTLD----LRPTNTDISMAVAGL 153

  Fly   163 IQYYGWQSIIYLYDSHDGLLRLQQIYQELKPGNETFRVQMVKRIANVTMAIEFLHTLEDLGRFSK 227
            :.::...:...:....|.||.|:.:.::.....||..|:|:....:.|      ..|:::.....
Zfish   154 LTFFNSSTSCLICAQADCLLNLEVLLRQFLISKETLSVRMLDDSQDPT------PLLKEIRDDKT 212

  Fly   228 KRIVLDCPAEMAKEIIVQHVRDIKLGRRTYHYLLSGLVMDNHWPSDVVEFGAINITGFRIVDSNR 292
            ..|::|..|.|: .:|::...::.:....|.|:|:.|........|:.: ..:||.||.:.:...
Zfish   213 ATIIVDANATMS-HVILERASELGMLSVYYTYILTSLEFSLLRLDDLAD-QRVNIVGFSVFNRTH 275

  Fly   293 RAVRDFHDSRKRLEPSGQSQSQNAGGPNSLPAISAQAALMYDAVFVLVEAFNRILRKKPDQFRSN 357
            ...:||..|..|........:..||.|.|       :||::|||..:|.|...:.|.:
Zfish   276 PFFQDFVLSLNRSWQENCDHAPFAGTPLS-------SALLFDAVHTVVAAVQELNRSQ------- 326

  Fly   358 HLQRRSHGGSSSSSATGTNESSALLDCNTSKGWVTPWEQGEKISRVLRKVEIDGLSGEIRFDEDG 422
                              |..:..|.|.:||    .||.|..:...||.||::||:|.|.|:..|
Zfish   327 ------------------NVGATQLSCKSSK----IWEHGTSLMNYLRMVELEGLTGHIEFNSKG 369

  Fly   423 RRINYTLHVVEMSVNSTLQQVAEWRDDAGLLPLHSHNYASSSRSASASTGDYDRNHTYIVSSLLE 487
            :|.||.|.:::.| ...|:|:.:|..:.||        :...:..|.:..|...|.|..::::||
Zfish   370 QRSNYALRIMQNS-RDGLRQIGQWHSEQGL--------SMERKLPSLNVTDTLFNTTLTITTILE 425

  Fly   488 EPYLSLKQYTYGESLVGNDRFEGYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAPGGWDGMV 552
            .||:.|:  ...:.|.||||:||:|.|:...||..|..||.||||.||.||...  |.|.|.|||
Zfish   426 NPYVMLR--ANHQELEGNDRYEGFCVDMLKELADILKFKYRIRLVGDGVYGVPG--ANGTWTGMV 486

  Fly   553 GELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPLSQEIWISV 617
            ||||.::||:|::|:|||||||:||||||||||||||||.:..:.:.||.||||:|.|..:|:.:
Zfish   487 GELISRKADLAVAALTITAEREKVIDFSKPFMTLGISIMYRVHIGRRPGYFSFLDPFSPGVWLFM 551

  Fly   618 ILSYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPNEFTMLN 682
            :|:|:.||.||:.|.|..||||   ..|.        |.:.|..:|.          .|::::.|
Zfish   552 LLAYLAVSCVLFLVARLTPYEW---YNPH--------PCLKGRCSLL----------INQYSLGN 595

  Fly   683 SFWYSLAAFMQQGCDITPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKTPEDLT 747
            |||:.:..|||||..|.|.:::.|..:.|||.||:|:||||||||||||||:||..||::.:||.
Zfish   596 SFWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPIESVDDLA 660

  Fly   748 MQTDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYMNANQHH-SVHTYDEGIRRVRQSKGKYALLVE 811
            .||.:.|||:..|||..||:.|:...:.:||.:|.:.|.. .|.:.:|||.||..|  .||.|:|
Zfish   661 DQTAIEYGTMHGGSTMTFFQNSRYQTYQRMWNFMYSKQPSVFVKSTEEGIARVLNS--NYAYLLE 723

  Fly   812 SPKNEYVNARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFDK 876
            |..|||...| .|:..::|..:||||:|:..|:||..|...:.|:|.|:|...|..::.||| |.
Zfish   724 STMNEYYRQR-NCNLTQIGGLLDTKGYGIGMPLGSVYRDEFDLAILRLQEENRLEILKRKWW-DG 786

  Fly   877 TECNLDQETSTPNELSLSNVAGIYYILIGGLLLAVIVAIMEF 918
            .:|. .:|......|.:.|:.||:.:|:.|||:|:.:|::||
Zfish   787 GKCP-KEEDHRAKGLGMENIGGIFVVLVCGLLVAIFMAVLEF 827

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375	100/419 (24%)
		ANF_receptor	53..434	CDD:279440	95/400 (24%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	181/402 (45%)
		Lig_chan	612..907	CDD:278489	114/295 (39%)
grik4	XP_021322087.1	Periplasmic_Binding_Protein_Type_1	26..400	CDD:324556	101/428 (24%)
grik4	XP_021322087.1	PBP2_iGluR_kainate_KA1	425..785	CDD:270442	177/388 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590905
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.750