DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIA and grik2

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	XP_021322472.1	Gene:	grik2 / 556013	ZFINID:	ZDB-GENE-080414-1	Length:	908	Species:	Danio rerio

Alignment Length:	903	Identity:	323/903 - (35%)
Similarity:	503/903 - (55%)	Gaps:	116/903 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 GAIFE------QGTDDVQSAFKYAM--LNHN---LNVSSRRFELQAYVDVINTADAFKLSRLICN 96
            |.|||      .|.:::  |||:|:  :|.|   |..::..:::|.    ||..|:|:.||..|:
Zfish    39 GGIFESIESGPSGAEEL--AFKFALNTINRNRTLLPNTTLTYDIQR----INIHDSFEASRKACD 97

  Fly    97 QFSRGVYSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLAPSSGLLDFAISMRPDY---HQA 158
            |.|.||.::.|.....|.:.:.|..|...:|.:...:..:|   |.....|.:::.||:   .:|
Zfish    98 QLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTKWKHQV---SDNRDSFYVNLYPDFSSLSRA 159

  Fly   159 IIDTIQYYGWQSIIYLYDSHDGLLRLQQIYQELKPGNETFRVQMVKRIANVTMAIEFLHTLEDLG 223
            |:|.:.::.|:::..:||...||:|||::.:  .|.....|:::.:..|:...|...   |:::.
Zfish   160 ILDLVHFFKWKTVTVVYDDSTGLIRLQELIK--APSRYNIRLKIRQLPADTKDAKPL---LKEMK 219

  Fly   224 RFSKKRIVLDCPAEMAKEIIVQHVRDIKLGRRT--YHYLLSGLVMDNHWPSDV--VEFGAINITG 284
            |..:..::.||..|||..|:.|   .:.:|..|  |||:.:.|.:   :..||  ..:..:|:||
Zfish   220 RGKEFHVIFDCGHEMAAGILKQ---ALAMGMMTEYYHYIFTTLDL---FALDVEPYRYSGVNMTG 278

  Fly   285 FRIVDSNRRAVRDFHD--SRKRLEPSGQSQSQNAGGPNSLPAISAQAALMYDAVFVLVEAFNRIL 347
            |||:::....|....:  |.:||:...:..|....|     .::..||||||||.|:..|    :
Zfish   279 FRILNTENSQVSSIIEKWSMERLQAPPKPDSGLLDG-----FMTTDAALMYDAVHVVAVA----V 334

  Fly   348 RKKPDQFRSNHLQRRSHGGSSSSSATGTNESSALLDCNTSKGWVTPWEQGEKISRVLRKVEIDGL 412
            ::.| |...:.||                       ||..|    ||..|.:...::::...|||
Zfish   335 QQSP-QITVSSLQ-----------------------CNRHK----PWRFGNRFMTLIKEAHWDGL 371

  Fly   413 SGEIRFDE-DGRRINYTLHVVEMSVNSTLQQVAEWRDDAGLLPLHSHNYASSSRSASASTGDYDR 476
            :|.|.|:. :|.|.::.|.|:.:. ...|:::..|...:||      |...:.:..:|:..|...
Zfish   372 TGRINFNRTNGLRTDFDLDVISLK-EEGLEKIGTWDPASGL------NMTENQKGKTANVTDSLS 429

  Fly   477 NHTYIVSSLLEEPYLSLKQYTYGESLVGNDRFEGYCKDLADMLAAQLGIKYEIRLVQDGNYGAEN 541
            |.:.:||::|||||:..|:  ..:.|.|||||||||.||...|||.||..||:|||:||.|||::
Zfish   430 NRSLVVSTILEEPYVMFKK--SDKPLYGNDRFEGYCVDLLRELAAILGFGYELRLVEDGRYGAQD 492

  Fly   542 QYAPGGWDGMVGELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFL 606
            : :.|.|:|||.||:..:||:|::.:.||..||:|||||||||||||||:.:||....|||||||
Zfish   493 E-SSGQWNGMVRELMDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFL 556

  Fly   607 NPLSQEIWISVILSYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQQPPGIIGGATLSEPQAHVP 671
            ||||.:||:.::|:|:|||.||:.:.||.||||........||
Zfish   557 NPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDS---------------------- 599

  Fly   672 PVPPNEFTMLNSFWYSLAAFMQQGCDITPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERM 736
            .|..|.||:|||||:.:.|.||||.::.|.:::.||...:|||||:|:|||||||||||||||||
Zfish   600 DVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERM 664

  Fly   737 VAPIKTPEDLTMQTDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYMNANQHH-SVHTYDEGIRRVR 800
            .:||.:.:||..||.:.||.:..|||..||::::|..::||||:|::.:|. .|.:.:|||.||.
Zfish   665 ESPIDSADDLAKQTKIEYGVVEDGSTMTFFKKTKISTYDKMWEFMSSRRHSVMVKSIEEGIERVL 729

  Fly   801 QSKGKYALLVESPKNEYVNARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKENGEL 865
            .|  .||.|:||...|:|..| .|:..::|..||:|.:||.||:|||.|.::..|:|.|:|.|:|
Zfish   730 TS--DYAFLMESTTIEFVTQR-NCNLTQIGGLIDSKAYGVGTPMGSPYRDKITIAILQLQEEGKL 791

  Fly   866 LRIRNKWWFDKTECNLDQETSTPNELSLSNVAGIYYILIGGLLLAVIVAIMEFFCRNK 923
            ..::.||| ....|. ::|....:.|.:.|:.||:.:|..||:|:|.||:.||..::|
Zfish   792 HMMKEKWW-RGNGCP-EEENKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSK 847

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375	111/430 (26%)
		ANF_receptor	53..434	CDD:279440	103/395 (26%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	192/402 (48%)
		Lig_chan	612..907	CDD:278489	121/295 (41%)
grik2	XP_021322472.1	PBP1_iGluR_Kainate	37..414	CDD:380605	113/438 (26%)
grik2	XP_021322472.1	Periplasmic_Binding_Protein_Type_2	430..800	CDD:419667	192/398 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590939
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.750