Protein Alignment GluRIA and grik2

DIOPT Version :10

• Sequence 1: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: NP_001410875.1
• Gene: grik2 / 556013
• ZFINID: ZDB-GENE-080414-1
• Length: 908
• Species: Danio rerio
• Alignment Length: 903
• Identity: 323/903 - (35%)
• Similarity: 503/903 - (55%)
• Gaps: 116/903 - (12%)

  Fly    43 GAIFE------QGTDDVQSAFKYAM--LNHN---LNVSSRRFELQAYVDVINTADAFKLSRLICN 96
            |.|||      .|.:::  |||:|:  :|.|   |..::..:::|.    ||..|:|:.||..|:
Zfish    39 GGIFESIESGPSGAEEL--AFKFALNTINRNRTLLPNTTLTYDIQR----INIHDSFEASRKACD 97

  Fly    97 QFSRGVYSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLAPSSGLLDFAISMRPDY---HQA 158
            |.|.||.::.|.....|.:.:.|..|...:|.:...:..:|   |.....|.:::.||:   .:|
Zfish    98 QLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTKWKHQV---SDNRDSFYVNLYPDFSSLSRA 159

  Fly   159 IIDTIQYYGWQSIIYLYDSHDGLLRLQQIYQELKPGNETFRVQMVKRIANVTMAIEFLHTLEDLG 223
            |:|.:.::.|:::..:||...||:|||::.:  .|.....|:::.:..|:...|...   |:::.
Zfish   160 ILDLVHFFKWKTVTVVYDDSTGLIRLQELIK--APSRYNIRLKIRQLPADTKDAKPL---LKEMK 219

  Fly   224 RFSKKRIVLDCPAEMAKEIIVQHVRDIKLGRRT--YHYLLSGLVMDNHWPSDV--VEFGAINITG 284
            |..:..::.||..|||..|:.|   .:.:|..|  |||:.:.|.:   :..||  ..:..:|:||
Zfish   220 RGKEFHVIFDCGHEMAAGILKQ---ALAMGMMTEYYHYIFTTLDL---FALDVEPYRYSGVNMTG 278

  Fly   285 FRIVDSNRRAVRDFHD--SRKRLEPSGQSQSQNAGGPNSLPAISAQAALMYDAVFVLVEAFNRIL 347
            |||:::....|....:  |.:||:...:..|....|     .::..||||||||.|:..|    :
Zfish   279 FRILNTENSQVSSIIEKWSMERLQAPPKPDSGLLDG-----FMTTDAALMYDAVHVVAVA----V 334

  Fly   348 RKKPDQFRSNHLQRRSHGGSSSSSATGTNESSALLDCNTSKGWVTPWEQGEKISRVLRKVEIDGL 412
            ::.| |...:.||                       ||..|    ||..|.:...::::...|||
Zfish   335 QQSP-QITVSSLQ-----------------------CNRHK----PWRFGNRFMTLIKEAHWDGL 371

  Fly   413 SGEIRFDE-DGRRINYTLHVVEMSVNSTLQQVAEWRDDAGLLPLHSHNYASSSRSASASTGDYDR 476
            :|.|.|:. :|.|.::.|.|:.:. ...|:::..|...:||      |...:.:..:|:..|...
Zfish   372 TGRINFNRTNGLRTDFDLDVISLK-EEGLEKIGTWDPASGL------NMTENQKGKTANVTDSLS 429

  Fly   477 NHTYIVSSLLEEPYLSLKQYTYGESLVGNDRFEGYCKDLADMLAAQLGIKYEIRLVQDGNYGAEN 541
            |.:.:||::|||||:..|:  ..:.|.|||||||||.||...|||.||..||:|||:||.|||::
Zfish   430 NRSLVVSTILEEPYVMFKK--SDKPLYGNDRFEGYCVDLLRELAAILGFGYELRLVEDGRYGAQD 492

  Fly   542 QYAPGGWDGMVGELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFL 606
            : :.|.|:|||.||:..:||:|::.:.||..||:|||||||||||||||:.:||....|||||||
Zfish   493 E-SSGQWNGMVRELMDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFL 556

  Fly   607 NPLSQEIWISVILSYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQQPPGIIGGATLSEPQAHVP 671
            ||||.:||:.::|:|:|||.||:.:.||.||||........||
Zfish   557 NPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDS---------------------- 599

  Fly   672 PVPPNEFTMLNSFWYSLAAFMQQGCDITPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERM 736
            .|..|.||:|||||:.:.|.||||.::.|.:::.||...:|||||:|:|||||||||||||||||
Zfish   600 DVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERM 664

  Fly   737 VAPIKTPEDLTMQTDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYMNANQHH-SVHTYDEGIRRVR 800
            .:||.:.:||..||.:.||.:..|||..||::::|..::||||:|::.:|. .|.:.:|||.||.
Zfish   665 ESPIDSADDLAKQTKIEYGVVEDGSTMTFFKKTKISTYDKMWEFMSSRRHSVMVKSIEEGIERVL 729

  Fly   801 QSKGKYALLVESPKNEYVNARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKENGEL 865
            .|  .||.|:||...|:|..| .|:..::|..||:|.:||.||:|||.|.::..|:|.|:|.|:|
Zfish   730 TS--DYAFLMESTTIEFVTQR-NCNLTQIGGLIDSKAYGVGTPMGSPYRDKITIAILQLQEEGKL 791

  Fly   866 LRIRNKWWFDKTECNLDQETSTPNELSLSNVAGIYYILIGGLLLAVIVAIMEFFCRNK 923
            ..::.||| ....|. ::|....:.|.:.|:.||:.:|..||:|:|.||:.||..::|
Zfish   792 HMMKEKWW-RGNGCP-EEENKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSK 847

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..456	CDD:380603	112/433 (26%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	192/402 (48%)
		Lig_chan	610..906	CDD:459656	122/296 (41%)
grik2	NP_001410875.1	PBP1_iGluR_Kainate	37..414	CDD:380605	113/438 (26%)
		Periplasmic_Binding_Protein_Type_2	430..800	CDD:473866	192/398 (48%)