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Protein Alignment GluRIA and Gria3

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	NP_001268858.2	Gene:	Gria3 / 53623	MGIID:	95810	Length:	888	Species:	Mus musculus

Alignment Length:	895	Identity:	381/895 - (42%)
Similarity:	536/895 - (59%)	Gaps:	88/895 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 IPLGAIFEQGTDDVQSAFKYA--MLNHNLNVSSRRFELQAYVDVINTADAFKLSRLICNQFSRGV 102
            |.:|.:|.:.|....|||::|  :.|.|.|.:.:.|.|..:||.::::::|.::...|:||||||
Mouse    28 ISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTTEKPFHLNYHVDHLDSSNSFSVTNAFCSQFSRGV 92

  Fly   103 YSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLAPSSGLLDFAISMRPDYHQAIIDTIQYYG 167
            |::.|.....|.:||.|:.......||||.|      |:...:.|.|.|||....||:..:.||.
Mouse    93 YAIFGFYDQMSMNTLTSFCGALHTSFVTPSF------PTDADVQFVIQMRPALKGAILSLLGYYK 151

  Fly   168 WQSIIYLYDSHDGLLRLQQIYQELKPGNETFRVQMVKRIANVTMAIEFLHTLEDLGRFSKKRIVL 232
            |:..:||||:..|...||.|.:.....|.....:.|..|.::.   ||...:|::.|..:||.::
Mouse   152 WEKFVYLYDTERGFSILQAIMEAAVQNNWQVTARSVGNIKDIQ---EFRRIIEEMDRRQEKRYLI 213

  Fly   233 DCPAEMAKEIIVQHVRDIKLGR--RTYHYLLSGLVMDNHWPSDV----VEFGAINITGFRIVDSN 291
            ||..|....|:.|.|   .||:  |.|||:|:.|..     :|:    |..|..|||||:||::.
Mouse   214 DCEVERINTILEQVV---ILGKHSRGYHYMLANLGF-----TDIVLERVMHGGANITGFQIVNNE 270

  Fly   292 RRAVRDFHDSRKRLEPSGQSQSQNAGGPNSLPAISAQAALMYDAVFVLVEAFNRILRKKPDQFRS 356
            ...|:.|.....||:.....:::||       .:...:||.:||:.|:.|||..:.|::.|
Mouse   271 NPMVQQFIQRWVRLDEREFPEAKNA-------PLKYTSALTHDAILVIAEAFRYLRRQRVD---- 324

  Fly   357 NHLQRRSHGGSSSSSATGTNESSALLDCNTSKGWVTPWEQGEKISRVLRKVEIDGLSGEIRFDED 421
              :.||...|                ||..:.  ..||.||..|.|.|:.|::.|::|.|:||..
Mouse   325 --VSRRGSAG----------------DCLANP--AVPWSQGIDIERALKMVQVQGMTGNIQFDTY 369

  Fly   422 GRRINYTLHVVEMSVNSTLQQVAEWRDDAGLLPLHSHNYASSSRSASASTGDYDRNHTYIVSSLL 486
            |||.|||:.|.||.|:.: ::...|.:....:|......::.|.|:        .|.|.:|:::|
Mouse   370 GRRTNYTIDVYEMKVSGS-RKAGYWNEYERFVPFSDQQISNDSSSS--------ENRTIVVTTIL 425

  Fly   487 EEPYLSLKQYTYGESLVGNDRFEGYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAPGGWDGM 551
            |.||:..|:  ..|.|.||:|:||||.|||..:|..:.|||::.:|.||.|||.:.... .|:||
Mouse   426 ESPYVMYKK--NHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETK-IWNGM 487

  Fly   552 VGELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPLSQEIWIS 616
            ||||:...||||::.:|||..||.|||||||||:||||||||||.|..|||||||:||:.|||:.
Mouse   488 VGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMC 552

  Fly   617 VILSYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPNEFTML 681
            ::.:|:|||.||:.|:||.||||.:      :...::|         .:||:  ||.|||||.:.
Mouse   553 IVFAYIGVSVVLFLVSRFSPYEWHL------EDNNEEP---------RDPQS--PPDPPNEFGIF 600

  Fly   682 NSFWYSLAAFMQQGCDITPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKTPEDL 746
            ||.|:||.|||||||||:|.|::|||...||||||:|:||||||||||||||||||:||::.|||
Mouse   601 NSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDL 665

  Fly   747 TMQTDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYM-NANQHHSVHTYDEGIRRVRQSKGKYALLV 810
            ..||::.||||..|||.||||||:|.::.|||.|| :|.......|..:|:.|||:||||:|.|:
Mouse   666 AKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAFLL 730

  Fly   811 ESPKNEYVNARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFD 875
            ||..|||:..|.||||||||.|:|:||:|||||.||.||..:|.|||.|.|.|.|.:::||||:|
Mouse   731 ESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALRTPVNLAVLKLSEQGILDKLKNKWWYD 795

  Fly   876 KTECNLDQETS--TPNELSLSNVAGIYYILIGGLLLAVIVAIMEFFCRNK 923
            |.||......|  ..:.||||||||::|||:|||.||::||::||..:::
Mouse   796 KGECGAKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFCYKSR 845

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.