Protein Alignment GluRIA and Gria3

DIOPT Version :10

• Sequence 1: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: NP_058582.4
• Gene: Gria3 / 53623
• MGIID: 95810
• Length: 888
• Species: Mus musculus
• Alignment Length: 896
• Identity: 381/896 - (42%)
• Similarity: 536/896 - (59%)
• Gaps: 90/896 - (10%)

  Fly    40 IPLGAIFEQGTDDVQSAFKYA--MLNHNLNVSSRRFELQAYVDVINTADAFKLSRLICNQFSRGV 102
            |.:|.:|.:.|....|||::|  :.|.|.|.:.:.|.|..:||.::::::|.::...|:||||||
Mouse    28 ISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTTEKPFHLNYHVDHLDSSNSFSVTNAFCSQFSRGV 92

  Fly   103 YSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLAPSSGLLDFAISMRPDYHQAIIDTIQYYG 167
            |::.|.....|.:||.|:.......||||.|      |:...:.|.|.|||....||:..:.||.
Mouse    93 YAIFGFYDQMSMNTLTSFCGALHTSFVTPSF------PTDADVQFVIQMRPALKGAILSLLGYYK 151

  Fly   168 WQSIIYLYDSHDGLLRLQQIYQELKPGNETFRVQMVKRIANVTMAIEFLHTLEDLGRFSKKRIVL 232
            |:..:||||:..|...||.|.:.....|.....:.|..|.::.   ||...:|::.|..:||.::
Mouse   152 WEKFVYLYDTERGFSILQAIMEAAVQNNWQVTARSVGNIKDIQ---EFRRIIEEMDRRQEKRYLI 213

  Fly   233 DCPAEMAKEIIVQHVRDIKLGR--RTYHYLLSGL-----VMDNHWPSDVVEFGAINITGFRIVDS 290
            ||..|....|:.|.|   .||:  |.|||:|:.|     |::.      |..|..|||||:||::
Mouse   214 DCEVERINTILEQVV---ILGKHSRGYHYMLANLGFTDIVLER------VMHGGANITGFQIVNN 269

  Fly   291 NRRAVRDFHDSRKRLEPSGQSQSQNAGGPNSLPAISAQAALMYDAVFVLVEAFNRILRKKPDQFR 355
            ....|:.|.....||:.....:::||       .:...:||.:||:.|:.|||..:.|::.|
Mouse   270 ENPMVQQFIQRWVRLDEREFPEAKNA-------PLKYTSALTHDAILVIAEAFRYLRRQRVD--- 324

  Fly   356 SNHLQRRSHGGSSSSSATGTNESSALLDCNTSKGWVTPWEQGEKISRVLRKVEIDGLSGEIRFDE 420
               :.||...|                ||..:.  ..||.||..|.|.|:.|::.|::|.|:||.
Mouse   325 ---VSRRGSAG----------------DCLANP--AVPWSQGIDIERALKMVQVQGMTGNIQFDT 368

  Fly   421 DGRRINYTLHVVEMSVNSTLQQVAEWRDDAGLLPLHSHNYASSSRSASASTGDYDRNHTYIVSSL 485
            .|||.|||:.|.||.|:.: ::...|.:....:|......::.|.|:        .|.|.:|:::
Mouse   369 YGRRTNYTIDVYEMKVSGS-RKAGYWNEYERFVPFSDQQISNDSSSS--------ENRTIVVTTI 424

  Fly   486 LEEPYLSLKQYTYGESLVGNDRFEGYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAPGGWDG 550
            ||.||:..|:  ..|.|.||:|:||||.|||..:|..:.|||::.:|.||.|||.:.... .|:|
Mouse   425 LESPYVMYKK--NHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETK-IWNG 486

  Fly   551 MVGELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPLSQEIWI 615
            |||||:...||||::.:|||..||.|||||||||:||||||||||.|..|||||||:||:.|||:
Mouse   487 MVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWM 551

  Fly   616 SVILSYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPNEFTM 680
            .::.:|:|||.||:.|:||.||||.:      :...::|         .:||:  ||.|||||.:
Mouse   552 CIVFAYIGVSVVLFLVSRFSPYEWHL------EDNNEEP---------RDPQS--PPDPPNEFGI 599

  Fly   681 LNSFWYSLAAFMQQGCDITPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKTPED 745
            .||.|:||.|||||||||:|.|::|||...||||||:|:||||||||||||||||||:||::.||
Mouse   600 FNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAED 664

  Fly   746 LTMQTDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYM-NANQHHSVHTYDEGIRRVRQSKGKYALL 809
            |..||::.||||..|||.||||||:|.::.|||.|| :|.......|..:|:.|||:||||:|.|
Mouse   665 LAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAFL 729

  Fly   810 VESPKNEYVNARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNKWWF 874
            :||..|||:..|.||||||||.|:|:||:|||||.||.||..:|.|||.|.|.|.|.:::||||:
Mouse   730 LESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALRTPVNLAVLKLSEQGILDKLKNKWWY 794

  Fly   875 DKTECNLDQETS--TPNELSLSNVAGIYYILIGGLLLAVIVAIMEFFCRNK 923
            ||.||......|  ..:.||||||||::|||:|||.||::||::||..:::
Mouse   795 DKGECGAKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFCYKSR 845

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..456	CDD:380603	131/423 (31%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	224/402 (56%)
		Lig_chan	610..906	CDD:459656	163/298 (55%)
Gria3	NP_058582.4	PBP1_iGluR_AMPA_GluR3	29..403	CDD:380610	131/423 (31%)
		PBP2_iGluR_AMPA	416..799	CDD:270433	224/402 (56%)