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Protein Alignment GluRIA and Gria1

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	NP_113796.1	Gene:	Gria1 / 50592	RGDID:	621531	Length:	907	Species:	Rattus norvegicus

Alignment Length:	972	Identity:	383/972 - (39%)
Similarity:	550/972 - (56%)	Gaps:	133/972 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 IPLGAIFEQGTDDVQSAFKYAMLNHNLNVSSRRFELQAYVDVINTADAFKLSRLICNQFSRGVYS 104
            |.:|.:|........:||::|     |:..:...:|...:|::|.:|:|:::...|:|||:|||:
  Rat    25 IQIGGLFPNQQSQEHAAFRFA-----LSQLTEPPKLLPQIDIVNISDSFEMTYRFCSQFSKGVYA 84

  Fly   105 MLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLAPSSGLLDFAISMRPDYHQAIIDTIQYYGWQ 169
            :.|.....:.:.|.|:.....:.|:||.||    ..:|.  .|.:.:||:..:|:|..|.:|.||
  Rat    85 IFGFYERRTVNMLTSFCGALHVCFITPSFP----VDTSN--QFVLQLRPELQEALISIIDHYKWQ 143

  Fly   170 SIIYLYDSHDGLLRLQQIYQELKPGNETFRVQMVKRIANVTMAIEFLHTLEDLGRFSKKRIVLDC 234
            :.:|:||:..||..||::.......|  ::|..|..:.........|  .:||.:..::.:|:||
  Rat   144 TFVYIYDADRGLSVLQRVLDTAAEKN--WQVTAVNILTTTEEGYRML--FQDLEKKKERLVVVDC 204

  Fly   235 PAEMAKEIIVQHVRDIKLGRRTYHYLLSGL-VMDNHWPSDVVEF---GAINITGFRIVDSN---- 291
            .:|....|:.|.|:..|.| ..|||:|:.| .||    .|:.:|   || |:|||::|:..
  Rat   205 ESERLNAILGQIVKLEKNG-IGYHYILANLGFMD----IDLNKFKESGA-NVTGFQLVNYTDTIP 263

  Fly   292 RRAVRDFH--DSRKRLEPSGQSQSQNAGGPNSLPAISAQAALMYDAVFVLVEAFNRILRKKPDQF 354
            .|.::.:.  |||.......:.....             :||.||.|.|:.|||..:.|::.|
  Rat   264 ARIMQQWRTSDSRDHTRVDWKRPKYT-------------SALTYDGVKVMAEAFQSLRRQRID-- 313

  Fly   355 RSNHLQRRSHGGSSSSSATGTNESSALLDCNTSKGWVTPWEQGEKISRVLRKVEIDGLSGEIRFD 419
                :.||.:.|                ||..:.  ..||.||..|.|.|::|..:||:|.::|:
  Rat   314 ----ISRRGNAG----------------DCLANP--AVPWGQGIDIQRALQQVRFEGLTGNVQFN 356

  Fly   420 EDGRRINYTLHVVEMSVNSTLQQVAEWRDDAGLLPLHSHNYASSSRSASASTGDYDRNHTYIVSS 484
            |.|||.||||||:||. :..::::..|.:|...:|..:...|....|:.       :|.||||::
  Rat   357 EKGRRTNYTLHVIEMK-HDGIRKIGYWNEDDKFVPAATDAQAGGDNSSV-------QNRTYIVTT 413

  Fly   485 LLEEPYLSLKQYTYGESLVGNDRFEGYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAPGGWD 549
            :||:||:.||:  ......||||:||||.:||..:|..:|..|.:.:|.||.|||.:.... .|:
  Rat   414 ILEDPYVMLKK--NANQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTK-AWN 475

  Fly   550 GMVGELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPLSQEIW 614
            ||||||:...||:|::.:|||..||.|||||||||:||||||||||.|..|||||||:||:.|||
  Rat   476 GMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIW 540

  Fly   615 ISVILSYVGVSFVLYFVTRFPPYEWRI--VRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPNE 677
            :.::.:|:|||.||:.|:||.||||..  ....:..:|:.|                     .||
  Rat   541 MCIVFAYIGVSVVLFLVSRFSPYEWHSEEFEEGRDQTTSDQ---------------------SNE 584

  Fly   678 FTMLNSFWYSLAAFMQQGCDITPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKT 742
            |.:.||.|:||.|||||||||:|.|::|||...||||||:|:||||||||||||||||||:||::
  Rat   585 FGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIES 649

  Fly   743 PEDLTMQTDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYM-NANQHHSVHTYDEGIRRVRQSKGKY 806
            .|||..||::.||||..|||.||||||:|.:..|||.|| :|.....|.|.:||:.|||:|||||
  Rat   650 AEDLAKQTEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKY 714

  Fly   807 ALLVESPKNEYVNARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNK 871
            |.|:||..|||:..|.||||||||.|:|:||:|:|||.||.||..:|.|||.|.|.|.|.:::||
  Rat   715 AYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRNPVNLAVLKLNEQGLLDKLKNK 779

  Fly   872 WWFDKTECNL---DQETSTPNELSLSNVAGIYYILIGGLLLAVIVAIMEF-------------FC 920
            ||:||.||..   |.:..| :.||||||||::|||||||.||::||::||             ||
  Rat   780 WWYDKGECGSGGGDSKDKT-SALSLSNVAGVFYILIGGLGLAMLVALIEFCYKSRSESKRMKGFC 843

  Fly   921 -----------RNKT-PQLKSPGSNGSAG-GVPGMLASSTYQRDSLSDAIMHSQAKLAMQAS 969
                       |..| |:....|::|..| |..|.:.|..:.:...|...|...:.:.:.|:
  Rat   844 LIPQQSINEAIRTSTLPRNSGAGASGGGGSGENGRVVSQDFPKSMQSIPCMSHSSGMPLGAT 905

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.