Protein Alignment GluRIA and grin2da

DIOPT Version :10

• Sequence 1: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: XP_073787594.1
• Gene: grin2da / 449864
• ZFINID: ZDB-GENE-041008-124
• Length: 1918
• Species: Danio rerio
• Alignment Length: 891
• Identity: 203/891 - (22%)
• Similarity: 352/891 - (39%)
• Gaps: 208/891 - (23%)

  Fly   129 VTPWFPEKVLAPSSGLLDFAISMRPDYHQAIIDTIQYYGWQSIIYLYDSHDGLLRLQ-------- 185
            :|||.|..|:                             |.::   .:|..|.|.||
Zfish   105 MTPWGPANVI-----------------------------WLAV---NESSPGSLLLQLCELLATT 137

  Fly   186 ----QIYQELK--PGNETFRVQMVKRI-ANVTMAIEFLHTLEDLGRFSKKR----IVLDCPAEMA 239
                .:::|.|  |.|......|::.: |...:.:..:.....|||..::.    :...|..::.
Zfish   138 PLQGLVFEEEKPPPPNRAPLAPMLEFVSAQTGVPVIAVGGGAGLGREPQESGSVYLQFSCSTDLQ 202

  Fly   240 KEIIVQHVRDIKL-----------GRRTYHYLLSGLVMDNH--WPSDVVEFGAINITG------- 284
            .|:|.:.:.:...           |...:..::.|::..:.  |....|..  :|:|.
Zfish   203 LEVIFEVLEEFDWTAFSVVTTRHHGYEDFLAMVEGMIDGSFIGWERKSVVM--LNLTDDPGGART 265

  Fly   285 FRIVDSNRRAVRDFHDSRKRLE-------PSGQSQSQN---AGGPNSLPAISAQAALMYDAVFVL 339
            .|::..|...||..:.|::..|       .|||:...:   |.|| .|..:..:.  :..|:|.:
Zfish   266 RRLLKENEAQVRLLYCSQEEAEQIFKAAWASGQATPSHMWFAVGP-GLSGLGLEG--LPKALFAV 327

  Fly   340 VEAFNRILRKKPDQFRSNHLQ----------------RRSHGGSSSSSATGTNESSALLDCNTSK 388
                      :|..:|....:                ||.:||:..:|..|    :.::|.|
Zfish   328 ----------RPQGWRDEPRRRIAKGVSVLTHGAMALRREYGGARGTSFAG----NCMMDGN--- 375

  Fly   389 GWVTPWEQGEKISRVLRKVEIDGLSG-EIRFDEDGRRINYTLHVVEMSVNSTLQQVAEWRDDAGL 452
                   |.:::...:|......||| :..|:.||...|..|.|:..:.....::|..|.:  |:
Zfish   376 -------QTQRVPGRIRFFSNITLSGRDYSFNNDGYLANPLLDVISYTAGRGWEEVGWWEN--GV 431

  Fly   453 LPLHSHNYASSSRSASASTGDYDRNHTYIVSSLLEEPYLSLKQYTYGES----------LVGNDR 507
            |.|   .|...||.........|..|..:| :|.|.|::.::....|..          |..|:|
Zfish   432 LRL---RYPPWSRYGPFLKPLDDSQHLRVV-TLEERPFVIVEPADPGTGSCIRDSVPCRLPLNNR 492

  Fly   508 --------------FEGYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAPGGWDGMVGELIRK 558
                          .:|:|.|:...||..:|..|::.||.:|.:|   :...|.|:|||||::.|
Zfish   493 SSMVVEGIQSMKHCCKGFCIDVLKRLAKIVGFTYDLYLVTNGRHG---KNIDGQWNGMVGEVVSK 554

  Fly   559 EADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPLSQEIWISVILSYVG 623
            .||:||.::||..||..|::||.||:..|||:|:.:. ..|....:||.|.|..:|:.:.:..:.
Zfish   555 RADMAIGSLTINEERSEVVEFSVPFVETGISVMVSRS-NGTVSPSAFLEPYSPAVWVMMFVMCLS 618

  Fly   624 VSFVLYFVTR-FPPYEWRIVRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPNEFTMLNSFWYS 687
            |..|..|:.. |.|..:.  |..|:..||       ||               ::||:..|.|..
Zfish   619 VVAVTVFIFEFFSPVGYN--RSLQSGKTA-------GG---------------SKFTIGKSIWLL 659

  Fly   688 LAAFMQQGCDI-TPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKTPEDLTMQ-- 749
            .|........: .|.....:|...||.||.:|.::|||||||||:..|..:..:....|...|
Zfish   660 WALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEEYIDTVSGLSDKKFQHP 724

  Fly   750 ----TDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYMNANQHHSVHTYDEGIRRVRQSKGKY-ALL 809
                ..:.:||:..|||.|..|.:...:|    :||..|....|....|.::     .||. |.:
Zfish   725 TEQYPPLRFGTVPNGSTEENIRSNYPNMH----QYMVRNNQRGVEDAIENLK-----TGKLDAFI 780

  Fly   810 VESPKNEYVNARPP-CDTMKV--GRNIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNK 871
            .::....|:..:.. |..|.:  |:...|.|:|||....|..::.|:.|:|.|..:.|:..:...
Zfish   781 YDAAVLNYMARKDEGCKVMTIGSGKVFATTGYGVALHKNSRWKRPLDLALLQLVGDDEIDMLERL 845

  Fly   872 WWFDKTECNLDQETSTPNELSLSNVAGIYYILIGGLLLAVIVAIME 917
            |.  ...|:.|:.....::|.:.|:||::|:|:..:.|:::|...|
Zfish   846 WL--SGICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWE 889

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..456	CDD:380603	69/392 (18%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	118/437 (27%)
		Lig_chan	610..906	CDD:459656	77/307 (25%)
grin2da	XP_073787594.1	None