DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GluRIA and grid2

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	NP_001004123.1	Gene:	grid2 / 448841	ZFINID:	ZDB-GENE-040913-1	Length:	1009	Species:	Danio rerio

Alignment Length:	983	Identity:	247/983 - (25%)
Similarity:	436/983 - (44%)	Gaps:	181/983 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 FLAYLHFICASSIFWPEFSSAQQQQQTVSLTEKIPLGAIFEQGTDDVQSAFKYAMLNHNLNVSSR 71
            |.|.|..|...|:.|          :.|.....|.:||||::........|:.|:.:.|||....
Zfish     4 FPAVLFLITFWSLEW----------EPVLPDSIIHIGAIFDESAKKDDEVFRMAVADLNLNNEIL 58

  Fly    72 RFE-LQAYVDVINTADAFKLSRLICNQFSRGVYSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPE 135
            ..| :...|:.::..:.|:..:..|...:||:.:::.::...|..:|.|.::...:|.:   |.:
Zfish    59 ETEKITVSVEFVDGNNPFQAVQEACELMNRGILALVSSIGCMSAGSLQSLADAMHIPHL---FIQ 120

  Fly   136 KVLA--PSSGLL--------DFAISMRPDYH--QAIIDTIQYYGWQSIIYLYDSHDGLLRLQQIY 188
            :..|  |.|...        |:.:.:||..:  ..|...:..|.||..|..||:...:..::...
Zfish   121 RAPAGTPRSSCPPTTRAQPDDYTLFVRPPVYLNDVIFQVVMEYTWQKFIIFYDTDYDIRGIENFL 185

  Fly   189 QELKPGNETFRVQMVKRIANV-------TMAIEFLHTLEDLGRFSKKRIVLDCPAEMAKEIIVQH 246
            .:.........:|.|:...|:       ||.:|.||...|    :.:|.||......||..|.:.
Zfish   186 DQTSQQGMDVSLQKVESNINMMITGMFRTMRVEELHRYRD----TLRRAVLFMSPATAKAFITEV 246

  Fly   247 VRDIKLGRRTYHYLLSGLV-MDNHW--------PSDVVEFGAINITGFRIV--------DSNRRA 294
            |.             :.|| .|..|        ..||.|....:|....:|        ::::|.
Zfish   247 VE-------------TNLVAFDCQWIIINEEISDMDVQELVMKSIGRLTLVRQTFPLPQNTSQRC 298

  Fly   295 VRDFHDSRKRL----EPSGQSQSQNAGGPNSLPAISAQAALMYDAVFVLVEAFNRILRKKPDQFR 355
            ||:.|.....|    :|..|             .:......:||.|.:|...|:|.|.
Zfish   299 VRNNHRINTSLCDPKDPKAQ-------------MLEITNRYIYDTVLLLANTFHRKLE------- 343

  Fly   356 SNHLQRRSHGGSSSSSATGTNESSALLDCNTSKGWVTPWEQGEKISRVLRKVEIDGLSGEIRFDE 420
                .|:.|             |.|.|.| ..|| ..||:.|:.:...::|..:.||:..:.|::
Zfish   344 ----DRKWH-------------SMASLSC-IRKG-SKPWQGGKSMLETVKKGGVSGLTSLLEFND 389

  Fly   421 DGRRINYTLHVVEMSVN------STLQQVAEWRDDAGLLPLHSHNYASSSRSASASTGDYDRNHT 479
            :|.  |..:|...:..|      ..:.::|.|.      |:|..|...:.|....:.    |...
Zfish   390 NGS--NPNIHFEILGTNYGEDRGRGVSRLATWD------PIHGLNGTLTDRKLENNM----RGVV 442

  Fly   480 YIVSSLLEEPYLSLKQYTYGESLVGNDRFEGYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYA 544
            ..|.::||||::.:.:...|:.    .:::|:..|:.|.||..||.||||.:..|..||  :|.|
Zfish   443 LRVVTVLEEPFVMVSENVLGKP----KKYQGFSIDVLDALANYLGFKYEIYVAPDHKYG--SQQA 501

  Fly   545 PGGWDGMVGELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPL 609
            .|.|:|::|||:.|.||:.:||:|||.|||.|:||:..:|...:.::::| .::|..:|:.|.|.
Zfish   502 DGTWNGLIGELVFKRADVGLSALTITPERESVVDFTTRYMDYSVGVLLRK-AERTVDMFACLAPF 565

  Fly   610 SQEIWISVILSYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQQPPGIIGGATLSEPQAHVPPVP 674
            ...:|..:..:.:.|..::|.:      .|            ..||.:..|:..|.
Zfish   566 DLSLWACIAGTVLLVGTLVYLL------NW------------LNPPRLPMGSVSST--------- 603

  Fly   675 PNEFTMLNSFWYSLAAFMQQGCDITPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAP 739
                |:.||.|:...:|:|||.::...::|.|:...|||.|.:|:|||||||||||||:.|:...
Zfish   604 ----TLYNSMWFVYGSFVQQGGEVPYTTLATRMMMGVWWLFALIVISSYTANLAAFLTISRIENS 664

  Fly   740 IKTPEDLTMQTDVNYGTLLYGSTWEFFRRSQIG------LHNKMWEYMN--ANQHHSVHTYDEGI 796
            |::.:||..|||:.|||:|..:.::..|...:.      ::::||..:|  ....::|....|||
Zfish   665 IQSLQDLAKQTDLPYGTVLDSAVYDQVRSKGMNPFERDPMYSQMWRMINRTGGAENNVEESKEGI 729

  Fly   797 RRVRQSKGKYALLVESPKNEYVNAR-PPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLK 860
            |:|:.  |::|.:.::...|||... ..|....|..|:..:|:|:|...|||.|...::.:|.|:
Zfish   730 RKVKY--GRFAFVWDAAVLEYVAINDEDCSLYTVSNNVADRGYGMAMQHGSPYRDIFSQRILELQ 792

  Fly   861 ENGELLRIRNKWWFDKTECNLDQETST---PNELSLSNVAGIYYILIGGLLLAVIVAIME-FFCR 921
            :||::..::.|||...:.|:|.....|   .:.|.:.:.||::::|..|::|:.::|.:| ::.|
Zfish   793 QNGDMDILKLKWWPRDSPCDLYSPVGTRKSGSALDIHSFAGVFFVLAAGVVLSCLIATVETWWTR 857

  Fly   922 NKTPQLKS 929
            .|..::.|
Zfish   858 RKGSRVPS 865

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375	93/458 (20%)
		ANF_receptor	53..434	CDD:279440	86/421 (20%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	127/410 (31%)
		Lig_chan	612..907	CDD:278489	86/306 (28%)
grid2	NP_001004123.1	PBP1_iGluR_delta_2	28..427	CDD:107386	95/465 (20%)
		ANF_receptor	42..404	CDD:279440	86/422 (20%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	126/405 (31%)
		Lig_chan	568..841	CDD:278489	86/305 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	989..1009
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810