Protein Alignment GluRIA and GluRIB

DIOPT Version :10

• Sequence 1: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: NP_001261621.2
• Gene: GluRIB / 44484
• FlyBaseID: FBgn0264000
• Length: 1182
• Species: Drosophila melanogaster
• Alignment Length: 1087
• Identity: 704/1087 - (64%)
• Similarity: 828/1087 - (76%)
• Gaps: 141/1087 - (12%)

  Fly    18 SIFWPEF-----------------SSAQQQQQTVSLTEKIPLGAIFEQGTDDVQSAFKYAMLNHN 65
            |..||.|                 .|||.     |||||||||||||||||:|||||||||||||
  Fly     8 SCLWPSFLLWLTWSSGGGGGSGVGVSAQP-----SLTEKIPLGAIFEQGTDEVQSAFKYAMLNHN 67

  Fly    66 LNVSSRRFELQAYVDVINTADAFKLSRLICNQFSRGVYSMLGAVSPDSFDTLHSYSNTFQMPFVT 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Fly    68 LNVSSRRFELQAYVDVINTADAFKLSRLICNQFSRGVYSMLGAVSPDSFDTLHSYSNTFQMPFVT 132

  Fly   131 PWFPEKVLAPSSGLLDFAISMRPDYHQAIIDTIQYYGWQSIIYLYDSHDGLLRLQQIYQELKPGN 195
            ||||||||.||||.||||:|||||||||||||||:|||:.|||||||||||||||||||.|:|||
  Fly   133 PWFPEKVLTPSSGFLDFALSMRPDYHQAIIDTIQFYGWRKIIYLYDSHDGLLRLQQIYQGLRPGN 197

  Fly   196 ETFRVQMVKRIANVTMAIEFLHTLEDLGRFSKKRIVLDCPAEMAKEIIVQHVRDIKLGRRTYHYL 260
            |:|:|::||||:||:||||||||||.:|||..|.||||||.||||:|::|||||::|||||||||
  Fly   198 ESFQVELVKRISNVSMAIEFLHTLEQIGRFENKHIVLDCPTEMAKQILIQHVRDLRLGRRTYHYL 262

  Fly   261 LSGLVMDNHWPSDVVEFGAINITGFRIVDSNRRAVRDFHDSRKRLEPSGQSQSQNAGGPNSLPAI 325
            |||||||:.|.|:::||||||||||||||:|||.||:|:||.|||:|   ..|..||    ..:|
  Fly   263 LSGLVMDDRWESEIIEFGAINITGFRIVDTNRRLVREFYDSWKRLDP---QMSVGAG----RESI 320

  Fly   326 SAQAALMYDAVFVLVEAFNRILRKKPDQFRSNHLQRRSH-----GGSSSSSATGTNES------- 378
            |||||||||||||||||||:|||||||||| |::||||.     ..::|:|:.|.|.|
  Fly   321 SAQAALMYDAVFVLVEAFNKILRKKPDQFR-NNVQRRSQTLMVAQAAASTSSDGYNYSASGGGGG 384

  Fly   379 --------------------SALLDCNTSKGWVTPWEQGEKISRVLRKVEIDGLSGEIRFDEDGR 423
                                |..|||||:||||..||.|:||||.||||||:||:|:|:|::|||
  Fly   385 NGGAGGGFAGSDSGGSGGMASRALDCNTAKGWVNAWEHGDKISRYLRKVEIEGLTGDIKFNDDGR 449

  Fly   424 RINYTLHVVEMSVNSTLQQVAEWRDDAGLLPLHSHNYASSSRSASASTGDYDRNHTYIVSSLLEE 488
            |:|||||||||:|||.:.:||||.|||||.||:: .|.......     ::::|.||||:::|||
  Fly   450 RVNYTLHVVEMTVNSAMVKVAEWNDDAGLQPLNA-KYVRLRPHV-----EFEKNRTYIVTTVLEE 508

  Fly   489 PYLSLKQYTYGESLVGNDRFEGYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAPGGWDGMVG 553
            ||:.|||..:||.|.||:|||||||||||:||.:|||.||:|||:|||||:|...|.||||||||
  Fly   509 PYIMLKQVAFGEKLHGNNRFEGYCKDLADLLAKELGINYELRLVKDGNYGSEKSSAHGGWDGMVG 573

  Fly   554 ELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPLSQEIWISVI 618
            ||:||||||||:|||||||||||||||||||:||||||||||||||||||||:||||||||:|||
  Fly   574 ELVRKEADIAIAAMTITAERERVIDFSKPFMSLGISIMIKKPVKQTPGVFSFMNPLSQEIWVSVI 638

  Fly   619 LSYVGVSFVLYFVTRFPPYEWRIV-RRPQADSTA-----------QQPPGIIGGATLSEPQAHVP 671
            .||:|||.||:||:||.|:|||:| ::||...:.           ||||||||||.|..|..  |
  Fly   639 FSYIGVSIVLFFVSRFSPHEWRLVQQQPQQSQSPDPHAHHEQLANQQPPGIIGGAPLPAPPG--P 701

  Fly   672 PVP-----------------------------PNEFTMLNSFWYSLAAFMQQGCDITPPSIAGRI 707
            |.|                             .|||::.||||:|||||||||||::|.|::|||
  Fly   702 PTPGAQTAAGAAALQAALSAGSPGSGGSSSAVVNEFSVWNSFWFSLAAFMQQGCDLSPRSVSGRI 766

  Fly   708 AAAVWWFFTIILISSYTANLAAFLTVERMVAPIKTPEDLTMQTDVNYGTLLYGSTWEFFRRSQIG 772
            |||.|:|||:||||||||||||||||||||.||.:||||.|||:|.|||||:||||:||||||||
  Fly   767 AAASWFFFTLILISSYTANLAAFLTVERMVTPINSPEDLAMQTEVQYGTLLHGSTWDFFRRSQIG 831

  Fly   773 LHNKMWEYMNANQHHSVHTYDEGIRRVRQSKGKYALLVESPKNEYVNARPPCDTMKVGRNIDTKG 837
            ||||||||||:.:|..|.||||||:|||.||||||||||||||||||||.||||||||||:||||
  Fly   832 LHNKMWEYMNSRKHVFVPTYDEGIKRVRNSKGKYALLVESPKNEYVNAREPCDTMKVGRNLDTKG 896

  Fly   838 FGVATPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFDKTECNL--DQETSTPNELSLSNVAGIY 900
            ||:|||:||.|:..:|.|||||||||||:::|||||::|.||:.  |.||| .:||||||||||:
  Fly   897 FGIATPLGSALKDPINLAVLTLKENGELIKLRNKWWYEKAECSTHKDGETS-HSELSLSNVAGIF 960

  Fly   901 YILIGGLLLAVIVAIMEFFCRNKTPQLKSPGS---------NGSAGG----------------VP 940
            ||||||||::|.|||:|:..|::..:..|.||         .|.:||                ||
  Fly   961 YILIGGLLVSVFVAILEYCFRSRDSRSASSGSGMGLGMGLGGGMSGGSLGKANGSMMLGPSSAVP 1025

  Fly   941 GMLASSTYQRDSLSDAIMHSQAKLAMQASSEYDERLVGVELASNVRY 987
            |.:.|| :||.:|:|. ||::|||.:|||.:||...||....::::|
  Fly  1026 GGMPSS-HQRSTLTDT-MHAKAKLTIQASRDYDNGRVGYLNCASLQY 1070

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..456	CDD:380603	326/446 (73%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	305/442 (69%)
		Lig_chan	610..906	CDD:459656	219/338 (65%)
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..480	CDD:380603	325/444 (73%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	305/442 (69%)
		Lig_chan	630..966	CDD:459656	219/338 (65%)