Protein Alignment GluRIA and GluRIID

DIOPT Version :10

• Sequence 1: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: NP_651982.1
• Gene: GluRIID / 44483
• FlyBaseID: FBgn0028422
• Length: 902
• Species: Drosophila melanogaster
• Alignment Length: 1012
• Identity: 294/1012 - (29%)
• Similarity: 471/1012 - (46%)
• Gaps: 168/1012 - (16%)

  Fly    11 LHFICASSIFWPEFSSAQQQ-----QQTVSLTEKIPLGAIFEQGTDDVQSAFKYA--MLNHNLNV 68
            :|| |..|:.....|..|.|     ....|..:.|.||.|.:..||.::..|::|  ::|:.|.|
  Fly     1 MHF-CWISLIILSLSRVQAQFYGGNAYEASSGQSIRLGLITDDATDRIRQTFEHAISVVNNELGV 64

  Fly    69 S-SRRFELQAYVDVINTADAFKLSRLICNQFSRGVYSMLGAVSPDSFDTLHSYSNTFQMPFVTPW 132
            . ....|..||.   |:..||   ..:|.....||.::.|..:..:...|.:..::..:||:.|.
  Fly    65 PLVGETEQVAYG---NSVQAF---AQLCRLMQSGVGAVFGPAARHTASHLLNACDSKDIPFIYPH 123

  Fly   133 FPEKVLAPSSGLLDFAISMRP-DYHQAIIDTIQYYGWQSIIYLYDSHDGLLRLQQIYQELKPGNE 196
                 |:..|....|.:...| |...|:.|.:..:.|...|:.|:|.:.|..|..:.........
  Fly   124 -----LSWGSNPDGFNLHPSPEDIANALYDIVNQFEWSRFIFCYESAEYLKILDHLMTRYGIKGP 183

  Fly   197 TFRVQMVKRIANVTMAIEFLHTLEDLGRFSKKRIVLDCPAEMAKEIIVQHVRDIKLGRRTYHYLL 261
            ..:|...    ::.:...:...|..:.:....|||:........|::.| .:.:.:....|.|::
  Fly   184 VIKVMRY----DLNLNGNYKSVLRRIRKSEDSRIVVVGSTTGVAELLRQ-AQQVGIMNEDYTYII 243

  Fly   262 SGLVMDNHWPSDVVE--FGAINITGFRIVDSNRRAVRDFHDSRKRLEPSGQSQSQNAGGPNSLPA 324
            ..|   |....|:.|  :...||||.|:...::..|||..:  |..:..|:|:..|:|.    ..
  Fly   244 GNL---NLHTFDLEEYKYSEANITGIRMFSPDQEEVRDLME--KLHQELGESEPVNSGS----TF 299

  Fly   325 ISAQAALMYDAVFVLVEAFNRILRKKPDQFRSNHLQRRSHGGSSSSSATGTNESSALLDCNTSKG 389
            |:.:.||.||||.|:.|.             :.||..:..                :|:|:....
  Fly   300 ITMEMALTYDAVRVIAET-------------TKHLPYQPQ----------------MLNCSERHD 335

  Fly   390 WVTPWEQGEKISRVLRKVEI--DGLSGEIRFDEDGRRINYTLHVVEMSVNSTLQQVAEWRDDAGL 452
            .|.|  .|......:|.:||  ..::|.|.|:.:.|: .:|..|:|:. .|.|.:|..|.:
  Fly   336 NVQP--DGSTFRNYMRSLEIKEKTITGRIYFEGNVRK-GFTFDVIELQ-TSGLVKVGTWEE---- 392

  Fly   453 LPLHSHNYASSSRSASASTGDYDR----NHTYIV-SSLLEEPYLSLKQYTYGESLVGNDRFEGYC 512
                ..::.......:.:..|.|.    |.|:|| .|:..:||.||.:..  ::|:||::|:||.
  Fly   393 ----GKDFEFQRPPQAVNFNDIDDGSLVNKTFIVLISVATKPYASLVESI--DTLIGNNQFQGYG 451

  Fly   513 KDLADMLAAQLGIKYEIRLVQDG--NYGAENQYAPGGWDGMVGELIRKEADIAISAMTITAERER 575
            .||...||.:||..:..|   ||  :||:.|: ......||:.|::...||:||:.:|||:|||.
  Fly   452 VDLIKELADKLGFNFTFR---DGGNDYGSFNK-TTNSTSGMLKEIVEGRADLAITDLTITSEREE 512

  Fly   576 VIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPLSQEIWISVILSYVGVSFVLYFVTRFPPYEWR 640
            |||||.|||.|||:|:..||.|..|.:|||::|.|.|:|:.:.::|:|||...:.:.|..|.||
  Fly   513 VIDFSIPFMNLGIAILYVKPQKAPPALFSFMDPFSSEVWLYLGIAYLGVSLCFFIIGRLSPIEW- 576

  Fly   641 IVRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGCDITPPSIAG 705
                       ..|          .|....|....|:||:.||.|::..|.:|||.:|.|.:::.
  Fly   577 -----------DNP----------YPCIEEPEELENQFTINNSLWFTTGALLQQGSEIAPKALST 620

  Fly   706 RIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKTPEDLT-MQTDVNYGTLLYGSTWEFFRRS 769
            |..:|:|||||:|::||||||||||||:|...:||.:.:||. .:.||.||....|||..||..|
  Fly   621 RTISAIWWFFTLIMVSSYTANLAAFLTIENPTSPINSVKDLADNKDDVQYGAKRTGSTRNFFSTS 685

  Fly   770 QIGLHNKMWEYMNANQHHSVHTYDEGIRRVRQSKGKYALLVESPKNEYVNARPPCDTMKVGRNID 834
            :..::.||.||:||:....:....:|:.:|: |..|||.|:||...|:...| .|:..|||..:|
  Fly   686 EEPIYIKMNEYLNAHPEMLMENNQQGVDKVK-SGTKYAFLMESTSIEFNTVR-ECNLTKVGDPLD 748

  Fly   835 TKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFD--KTECNLDQETSTPNELSLSNVA 897
            .||:|:|.....|.|.:.|:|:|.|:|.|.|.|::||||.:  ...|:...:...|:||.:.|::
  Fly   749 EKGYGIAMVKNWPYRDKFNKALLELQEQGVLARLKNKWWNEVGAGVCSAKSDDDGPSELGVDNLS 813

  Fly   898 GIYYILIGGLLLAVIVAIM-----------------------EF-----FCRNKTPQLKSPGSNG 934
            |||.:|:.|.::::|::|:                       ||     |..|:.| |||
  Fly   814 GIYVVLVIGSIISIIISILCWCYFVYKKAKNYEVPFCDALAEEFRIVIRFSENERP-LKS----- 872

  Fly   935 SAGGVPGMLASSTYQRDSLSDAIMHSQAKLAMQASSE 971
                     |.|.|.|...|     ||:..:::..||
  Fly   873 ---------AQSIYSRSRNS-----SQSIESLKTDSE 895

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..456	CDD:380603	93/422 (22%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	161/407 (40%)
		Lig_chan	610..906	CDD:459656	110/298 (37%)
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..400	CDD:380605	93/430 (22%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	160/400 (40%)
		Lig_chan	547..819	CDD:459656	109/295 (37%)