DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIA and CG11155

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	NP_651941.2	Gene:	CG11155 / 43822	FlyBaseID:	FBgn0039927	Length:	910	Species:	Drosophila melanogaster

Alignment Length:	952	Identity:	302/952 - (31%)
Similarity:	473/952 - (49%)	Gaps:	150/952 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 AYLHFICASSIFWP--EFSSAQQQQQTVSLTEKIPLGAIF--EQGTDDVQSAFKYAMLNHNLNVS 69
            :||..||.|.|...  ..|:|        |...|.:||||  ::....::||||||:  :.:|..
  Fly    18 SYLKKICCSYIILSILVISNA--------LPPVIRVGAIFTEDERESSIESAFKYAI--YRINKE 72

  Fly    70 SR---RFELQAYVDVINTADAFKLSRLICNQFSRGVYSMLGAVSPDSFDTLHSYSNTFQMPFVTP 131
            ..   ..:|...::.:...|:|:.::.:|:|...||.::.|.........:.|....:.:|.:
  Fly    73 KTLLPNTQLVYDIEYVPRDDSFRTTKKVCSQLEAGVQAIFGPTDALLASHVQSICEAYDIPHI-- 135

  Fly   132 WFPEKVLAPSSGLLD-------FAISMRPDY---HQAIIDTIQYYGWQSIIYLYDSHDGLLRLQQ 186
                      .|.:|       |:|::.|.:   ..|..|.:.|..|..:..:|:...||..|..
  Fly   136 ----------EGRIDLEYNSKEFSINLYPSHTLLTLAYRDIMVYLNWTKVAIIYEEDYGLFNLMH 190

  Fly   187 IYQELKPGNETFRVQMVKRIANVTMAIEFLHTLEDLGRFSKKRIVLDCPAEMAKEIIVQHVRDIK 251
            ...|.|       .:|..|.|:.....:.|..:.....:   :|::|......|... :.:..::
  Fly   191 SSTETK-------AEMYIRQASPDSYRQVLRAIRQKEIY---KIIVDTNPSHIKSFF-RSILQLQ 244

  Fly   252 LGRRTYHYLLSGLVMDNHWPSDVVEF--GAINITGFRIVDSNRRAVRDFHDSRKRLEPSGQSQSQ 314
            :....|||:.:...::.:   |:.:|  .::|||.||:||.         ||::.||...|.|..
  Fly   245 MNDHRYHYMFTTFDLETY---DLEDFRYNSVNITAFRLVDV---------DSKRYLEVINQMQKL 297

  Fly   315 NAGG---PNSLPAISAQAALMYDAVFVLVEAFNRILRKKPDQFRSNHLQRRSHGGSSSSSATGTN 376
            ...|   .|..|.|..::|||:|:|:......:.:.......|...:|       |.:|..|
  Fly   298 QHNGLDTINGSPYIQTESALMFDSVYAFANGLHFLNLDNHQNFYIKNL-------SCTSDQT--- 352

  Fly   377 ESSALLDCNTSKGWVTPWEQGEKISRVLRKVEIDGLSGEIRFDEDGRRINYTLHVVEMSVNSTLQ 441
                             |..|..:...:.....|||:|.::|.| |||..:.|.::::. ...:|
  Fly   353 -----------------WNDGISLYNQINAAITDGLTGTVQFVE-GRRNIFKLDILKLK-QEKIQ 398

  Fly   442 QVAEWRDDAGLLPLHSHNYASSSRSASASTGDYD---RNHTYIVSSLLEEPYLSLKQYTYGESLV 503
            :|..|..|.|:             :.|..|..||   .|.|.:|.:..|.||:.:|:   .::|.
  Fly   399 KVGYWHPDDGV-------------NISDPTAFYDSNIANITLVVMTREERPYVMVKE---DKNLT 447

  Fly   504 GNDRFEGYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAP--GGWDGMVGELIRKEADIAISA 566
            ||.||||:|.||...:|.|:|.:|:|.||.|..||.   |.|  ..|:|:|.||:.:.||:|:::
  Fly   448 GNLRFEGFCIDLLKAIATQVGFQYKIELVPDNMYGV---YIPETNSWNGIVQELMERRADLAVAS 509

  Fly   567 MTITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPLSQEIWISVILSYVGVSFVLYFV 631
            |||...||.||||:||||.|||.|:.|.|..|...:|||:|||:.|||:.|:.:|:.|||.|:.:
  Fly   510 MTINYARESVIDFTKPFMNLGIGILFKVPTSQPTRLFSFMNPLAIEIWLYVLAAYILVSFALFVM 574

  Fly   632 TRFPPYEWRIVRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGC 696
            .||.||||:            .|          .|......:..|:|::.||||:....|::||.
  Fly   575 ARFSPYEWK------------NP----------HPCYKETDIVENQFSISNSFWFITGTFLRQGS 617

  Fly   697 DITPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKTPEDLTMQTDVNYGTLLYGS 761
            .:.|.:.:.||....|:||.:|:|||||||||||||||||::||::..||..||:::||||..||
  Fly   618 GLNPKATSTRIVGGCWFFFCLIIISSYTANLAAFLTVERMISPIESASDLAEQTEISYGTLEGGS 682

  Fly   762 TWEFFRRSQIGLHNKMWEYM-NANQHHSVHTYDEGIRRVRQSKGKYALLVESPKNEYVNARPPCD 825
            |..|||.|:||::.|||.|| |......|.||::||:||.:  |.||.|:||...:|...| .|:
  Fly   683 TMTFFRDSKIGIYQKMWRYMENRKTAVFVKTYEDGIKRVME--GSYAFLMESTMLDYAVQR-DCN 744

  Fly   826 TMKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFDKTE-CNLDQET--ST 887
            ..::|..:|:||:|:|||.|||.|.:::.|:|.|:|.|.:..:.:|||.:..: ||.|.::  |.
  Fly   745 LTQIGGLLDSKGYGIATPKGSPWRDKISLAILELQEKGIIQILYDKWWKNTGDVCNRDDKSKESK 809

  Fly   888 PNELSLSNVAGIYYILIGGLLLAVIVAIMEFFCRNKTPQLKS 929
            .|.|.:.|:.|::.:|:.||.|||:|||.| ||.|....|.:
  Fly   810 ANALGVENIGGVFVVLLCGLALAVVVAIFE-FCWNSRKNLNT 850

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375	92/431 (21%)
		ANF_receptor	53..434	CDD:279440	83/398 (21%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	174/405 (43%)
		Lig_chan	612..907	CDD:278489	120/298 (40%)
CG11155	NP_651941.2	PBP1_iGluR_Kainate	44..410	CDD:107377	92/444 (21%)
		ANF_receptor	61..393	CDD:279440	82/396 (21%)
		PBP2_iGluR_Kainate	424..793	CDD:270432	173/399 (43%)
		Lig_chan	555..829	CDD:278489	120/298 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462572
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.740