Protein Alignment GluRIA and Ekar

DIOPT Version :10

• Sequence 1: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: NP_001036250.1
• Gene: Ekar / 43806
• FlyBaseID: FBgn0039916
• Length: 899
• Species: Drosophila melanogaster
• Alignment Length: 981
• Identity: 296/981 - (30%)
• Similarity: 492/981 - (50%)
• Gaps: 168/981 - (17%)

  Fly    40 IPLGAIF--EQGTDDVQSAFKYAMLNHNLNVSSR---RFELQAYVDVINTADAFKLSRLICNQFS 99
            :.:||||  :.|..:.:.||:||:  |.||:...   ...:..||:.:|..|:|:..:.:|....
  Fly    23 VRIGAIFSNQPGMYNSELAFRYAI--HRLNMDKSLLPETTVDYYVEYVNRFDSFETVQKVCKLIR 85

  Fly   100 RGVYSMLGAVSP-DSFDTLH--SYSNTFQMPFVTPWFPEKVLAPSSGLLDFAISMRPD---YHQA 158
            .||.::.   || ||....|  |..:...:|.:           .....||:|::.|.   .:.|
  Fly    86 VGVQAVF---SPTDSVLATHINSICDALDIPNI-----------GRSAHDFSINVYPSKQLVNYA 136

  Fly   159 IIDTIQYYGWQSIIYLYDSHDGLLRLQQIYQELKPGNETFRVQMVKRIANVTMAIEF----LHTL 219
            ..|.|||..|.....|::..:|::.|.|:.:..   :....::.|.|.:.|:...||    :|
  Fly   137 FNDVIQYLNWTRFGILHEKENGIINLHQLSRSF---HGEVHMRQVSRDSYVSALNEFKGKEIH-- 196

  Fly   220 EDLGRFSKKRIVLDCPAE----MAKEIIVQHVRDIKLGRRTYHYLLSGLVMDNHWPSDVVEFGAI 280
                     .|::|..:.    :.|.|:.|.:.:.|     ||||.:...::.:...| .::..:
  Fly   197 ---------NIIIDTNSNGISILLKNILQQQMNEYK-----YHYLFTSFDLETYDLED-FKYNFV 246

  Fly   281 NITGFRIVDSNRRAVRDFHDSRKRLEPSGQSQSQNAGGP------NSLPAISAQAALMYDAVFVL 339
            |||.||:||:....|:..      |:..|.........|      .....:.::.|||:|:|:|.
  Fly   247 NITSFRLVDTADVGVKQI------LKDIGLYSHHIFKKPYLNLHIKKSTILESEPALMFDSVYVF 305

  Fly   340 VEAFNRILRKKPDQFRSNHLQRRSHGGSSSSSATGTNESSALLDCNTSKGWVTPWEQGEKISRVL 404
            ......:              .:||      |.|..|     :.|.....    |:.|..:...|
  Fly   306 AIGLQTL--------------EQSH------SLTLLN-----ISCEEENS----WDGGLSLINYL 341

  Fly   405 RKVEIDGLSGEIRFDEDGRRINYTLHVVEMSVNSTLQQVAEWRDDAGLLPLHSH-NYASSSRSAS 468
            ..||..||:|.|:| :||:|:.:.|.::::..:| :.:|.||..       |.| |....|....
  Fly   342 NAVEWKGLTGPIQF-KDGQRVQFKLDLIKLKQHS-IVKVGEWTP-------HGHLNITEPSMFFD 397

  Fly   469 ASTGDYDRNHTYIVSSLLEEPYLSLKQYTYGESLVGNDRFEGYCKDLADMLAAQLGIKYEIRLVQ 533
            |.:    .|.|.:|.::||.||:.:.   ||::..||:||.|:|.|:.:.::.::|..|.:.||.
  Fly   398 AGS----MNVTLVVITILETPYVMMH---YGKNFTGNERFYGFCVDILETISREVGFDYILDLVP 455

  Fly   534 DGNYGAENQYAPGGWDGMVGELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQ 598
            |..|||::. ..|.|:|||.:|::.:||:|:.:||||..||.||||:||||.|||||:.|.|..:
  Fly   456 DRKYGAKDP-ETGEWNGMVAQLMKYKADLAVGSMTITYARESVIDFTKPFMNLGISILFKVPTSE 519

  Fly   599 TPGVFSFLNPLSQEIWISVILSYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQQPPGIIGGATL 663
            ...:|||:|||:.||||.|:::|..||..:|.|.:..|.||:.:.....::.:      ||
  Fly   520 PTRLFSFMNPLAIEIWIYVLIAYFLVSLCIYIVGKLSPIEWKCINACDLENIS------IG---- 574

  Fly   664 SEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGCDITPPSIAGRIAAAVWWFFTIILISSYTANLA 728
                        |:|::.:|||:::..||||..||.|.:::.||.::.|.||::|:::|||||||
  Fly   575 ------------NQFSLTDSFWFTIGTFMQQSPDIYPRAMSTRIISSTWGFFSLIIVASYTANLA 627

  Fly   729 AFLTVERMVAPIKTPEDLTMQTDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYMNANQHHSVH--T 791
            ||||.|||:.||:..|||..||:::||||..|||..|||.|.|..:.|:|..|: |:..|..  |
  Fly   628 AFLTTERMINPIENAEDLASQTEISYGTLDSGSTMTFFRDSVIETYKKIWRSMD-NKKPSAFTTT 691

  Fly   792 YDEGIRRVRQSKGKYALLVESPKNEYVNARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAV 856
            |::||:||.|  |.||.|:||...:|:..| .|:..::|..:||||:|:|||.|||.|.:::.|:
  Fly   692 YEDGIKRVNQ--GNYAFLMESTMLDYIVQR-DCNLTQIGGLLDTKGYGIATPKGSPWRDKISLAI 753

  Fly   857 LTLKENGELLRIRNKWWFDKTECNLDQET---STPNELSLSNVAGIYYILIGGLLLAVIVAIMEF 918
            |.|:|.|::..:.:|||.:..|....:.|   |..|.|.|.::.|::.:||.|:::|.:||..||
  Fly   754 LELQERGDIQMLYDKWWKNTDETCTRKNTSKQSKANSLGLESIGGVFVVLIAGIIVAAVVAFFEF 818

  Fly   919 FCRNKTPQLKSPGSNGSAGGVPGMLASSTYQRDSLSDAIMHSQAKLAMQASSEY--DERLVGVEL 981
            :...:.....:|..:         :.::.|.:|.:            :::...|  .:|...:|:
  Fly   819 WYNFRYNYEATPSQS---------VVNNKYNQDGI------------LESERNYTPPDRSFWIEI 862

  Fly   982 ASNVRY 987
            |..:||
  Fly   863 AEELRY 868

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..456	CDD:380603	99/439 (23%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	168/403 (42%)
		Lig_chan	610..906	CDD:459656	117/300 (39%)
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..390	CDD:380605	102/445 (23%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	167/398 (42%)
		Lig_chan	532..806	CDD:459656	117/299 (39%)