Protein Alignment GluRIA and Grik

DIOPT Version :10

• Sequence 1: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: NP_001262788.1
• Gene: Grik / 42476
• FlyBaseID: FBgn0038840
• Length: 907
• Species: Drosophila melanogaster
• Alignment Length: 988
• Identity: 276/988 - (27%)
• Similarity: 454/988 - (45%)
• Gaps: 184/988 - (18%)

  Fly    38 EKIPLGAIFEQGTDDVQSAFKYAMLNHNLNVSSRRFELQAYVDVINTADAFKLSRLICNQFSRGV 102
            |:..:|.::|....|::..|..|:  ...|..:...:|......|...::|:.|:.:|....:.:
  Fly    32 ERTNVGLVYENTDPDLEKIFHLAI--SKANEENEDLQLHGVSVSIEPGNSFETSKKLCKMLRQNL 94

  Fly   103 YSMLGAVSPDSFDTLHSYSNTFQMPFV-TPWFPEKVLAPSSGLLDF-----AISMRPDYHQAII- 160
            .::.|..|..:.....|..:..::||: |.|             ||     .|::.|  |.|.:
  Fly    95 VAVFGPTSNLAARHAMSICDAKELPFLDTRW-------------DFGAQLPTINLHP--HPATLG 144

  Fly   161 ----DTIQYYGWQSIIYLYDSHDGLLRLQQIYQELKPGNETFRVQ------------MVKRIANV 209
                |.:...||:|...:|:|.:.|..::::.|.......|..|:            :::||.|.
  Fly   145 VALRDMVVALGWESFTIIYESGEYLPTVRELLQMYGTAGPTVTVRRYELDLNGNYRNVLRRIRNA 209

  Fly   210 -TMAIEFLHTLEDLGRFSKKRIVLDCPAEMAKEIIVQHVRDIKLGRRTYHYLLSGL---VMDNHW 270
             ..:...:.::..|..|.|:                  .:.:.|....|.|::..|   .||
  Fly   210 DDFSFVVVGSMATLPEFFKQ------------------AQQVGLVTSDYRYIIGNLDWHTMD--- 253

  Fly   271 PSDVVEFGAINITGFRIVDSNRRAVRDFHDSRKRLEPSGQSQSQNAGGP--NSLPAISAQAALMY 333
             .:..:....||||.|:|..:...|::.   .|.|..| :...||...|  ||:       ||:|
  Fly   254 -LEPYQHAGTNITGLRLVSPDSEQVQEV---AKALYES-EEPFQNVSCPLTNSM-------ALVY 306

  Fly   334 DAVFVLVEAFNRILRKKPDQFRSNHLQRRSHGGSSSSSATGTNESSALLDCNTSKGWVTPWEQGE 398
            |.|.:|.|.:..:                             |.....|.||..    :.|::|.
  Fly   307 DGVQLLAETYKHV-----------------------------NFRPVALSCNDD----SAWDKGY 338

  Fly   399 KISRVLRKVEIDGLSGEIRFDEDGRRINYTLHVVEMSVNSTLQQVAEWRDDAGL---LPLHSHNY 460
            .:...::.:.::||:|.||||.:|.|.::.|.|:|::| |.:|::.:|..:.|.   .|..:|:.
  Fly   339 TLVNYMKSLTLNGLTGPIRFDYEGLRTDFKLEVIELAV-SGMQKIGQWSGEDGFQENRPAPAHSL 402

  Fly   461 ASSSRSASASTGDYDRNHTYIVSSLLEEPYLSLKQYTYGESLVGNDRFEGYCKDLADMLAAQLGI 525
            ....||..        |.:::|.:.:.|||..||:.:  |.|.|||:|||:..:|.|.|:.:||.
  Fly   403 EPDMRSLV--------NKSFVVITAISEPYGMLKETS--EKLEGNDQFEGFGIELIDELSKKLGF 457

  Fly   526 KYEIRLVQDGNYGAENQYAPGGWDGMVGELIRKEADIAISAMTITAERERVIDFSKPFMTLGISI 590
            .|..||.:|..||..:. ..|.|:||:.|:|...||:.|:.:|:|:|||..:||:.|||:|||.|
  Fly   458 SYTWRLQEDNKYGGIDP-KTGEWNGMLREIIDSRADMGITDLTMTSERESGVDFTIPFMSLGIGI 521

  Fly   591 MIKKPVKQTPGVFSFLNPLSQEIWISVILSYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQQPP 655
            :.:||:|:.|.:|||::|.|.|:|:.:.|:|:|||..::.:.|..|.||            ..|
  Fly   522 LFRKPMKEPPKLFSFMSPFSGEVWLWLGLAYMGVSISMFVLGRLSPAEW------------DNP- 573

  Fly   656 GIIGGATLSEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGCDITPPSIAGRIAAAVWWFFTIILI 720
                     .|....|....|:|:..|..|:|:.|.:|||.::.|.:.:.|..||.|||||:||:
  Fly   574 ---------YPCIEEPTELENQFSFANCLWFSIGALLQQGSELAPKAYSTRAVAASWWFFTLILV 629

  Fly   721 SSYTANLAAFLTVERMVAPIKTPEDLTM-QTDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYMNAN 784
            ||||||||||||||.:|.||...:||:. :..||||..:.|:|:.||:.|....:.:|:|:|..|
  Fly   630 SSYTANLAAFLTVESLVTPINDADDLSKNKGGVNYGAKIGGATFNFFKESNYPTYQRMYEFMRDN 694

  Fly   785 QHHSVHTYDEGIRRVRQSKGKYALLVESPKNEYVNARPPCDTMKVGRNIDTKGFGVATPIGSPLR 849
            ..:..:|..||:.||..|  .||.|:||...||:..| .|...:||..:|.||:|:|.....|.|
  Fly   695 PQYMTNTNQEGVDRVENS--NYAFLMESTTIEYITER-RCTLTQVGALLDEKGYGIAMRKNWPYR 756

  Fly   850 KRLNEAVLTLKENGELLRIRNKWWFDKT---ECNLDQETSTPNELSLSNVAGIYYILIGGLLLAV 911
            ..|::|||.::|.|.|.:::.|||.:|.   .|:...|.|....|.:||:.|::.::..|....:
  Fly   757 DTLSQAVLEMQEQGLLTKMKTKWWQEKRGGGACSDADEDSGAVALEISNLGGVFLVMGVGSFFGI 821

  Fly   912 IVAIMEFF---------------------------CRNKTPQLKSPGSNGSAGGVPGMLASSTYQ 949
            .|:::|..                           |...|..:|.| .|.|..........|:..
  Fly   822 FVSLLEMVLGVKERSDENQVSFKTELLDEIRFILQCSGNTKAVKYP-KNSSRSNASSKSKGSSMS 885

  Fly   950 RDSLSDAIMHSQA 962
            .|||.:....:.|
  Fly   886 VDSLPEDTSEADA 898

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..456	CDD:380603	92/446 (21%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	159/405 (39%)
		Lig_chan	610..906	CDD:459656	109/299 (36%)
Grik	NP_001262788.1	PBP1_iGluR_Kainate	35..395	CDD:380605	91/443 (21%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:473866	157/397 (40%)