DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIA and KaiR1D

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster

Alignment Length:	905	Identity:	294/905 - (32%)
Similarity:	498/905 - (55%)	Gaps:	106/905 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 SLTEKIPLGAIFEQGTDDVQSAFKYAM--LNHNLNVSSRRFELQAYVDVINTADAFKLSRLICNQ 97
            ||.:.|.:|.:|....|..:.||:.|:  :|.:.::..|. :|.|.::.|:..|:|...:.:|..
  Fly    25 SLPDIIKIGGLFHPADDHQELAFRQAVDRINADRSILPRS-KLVAQIERISPFDSFHAGKRVCGL 88

  Fly    98 FSRGVYSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLAPSSGLLDFAISMRP---DYHQAI 159
            .:.||.::.|..|..:...:.|..:..::|.:...:..::...|.     .:::.|   ...:|.
  Fly    89 LNIGVAAIFGPQSSHTASHVQSICDNMEIPHLENRWDYRLRRESC-----LVNLYPHPNTLSKAY 148

  Fly   160 IDTIQYYGWQSIIYLYDSHDGLLRLQQIYQELKPGNETFRVQMVKRIANVTMAIEFLHTLEDLGR 224
            :|.::::||::...:|:::||::|||::   ||....|.....|:::::   :.::...|:.:..
  Fly   149 VDIVRHWGWKTFTIIYENNDGIVRLQEL---LKAHGMTPFPITVRQLSD---SGDYRPLLKQIKN 207

  Fly   225 FSKKRIVLDCPAEMAKEIIVQHVRDIKLGRRTYHYLLSGLVMDNHWPS-DVVEFGAINITGFRIV 288
            .::..|||||..|...|::.| .:.|.:....:.||::.|  |.|..: |...:|..||||||::
  Fly   208 SAEAHIVLDCSTERIHEVLKQ-AQQIGMMSDYHSYLVTSL--DLHTVNLDEFRYGGTNITGFRLI 269

  Fly   289 DSNRRAVRDFHDSRKRLEPSGQSQSQNAGGPNSLPAISAQAALMYDAVFVLVEAFNRILRKKPDQ 353
              |.:.|.|. ..:..::..|..:|.|      |..:.::.|||||||.:..:|.:.:     |.
  Fly   270 --NEKIVSDV-VRQWSIDEKGLLRSAN------LTTVRSETALMYDAVHLFAKALHDL-----DT 320

  Fly   354 FRSNHLQRRSHGGSSSSSATGTNESSALLDCNTSKGWVTPWEQGEKISRVLRKVEIDGLSGEIRF 418
            .:...:...|..|.|:                        |:.|..:...::.||:.||:..|:|
  Fly   321 SQQIDIHPISCDGQST------------------------WQHGFSLINYMKIVEMKGLTNVIKF 361

  Fly   419 DEDGRRINYTLHVVEMSVNSTLQQVAEWRDDAGLLP---LHSHNYASSSRSASASTGDYDRNHTY 480
            |..|.|.::.|.:||:: .:.::::..|.   ..||   ..:..::...:...|:.    :|.|.
  Fly   362 DHQGFRTDFMLDIVELT-PAGIRKIGTWN---STLPDGINFTRTFSQKQQEIEANL----KNKTL 418

  Fly   481 IVSSLLEEPYLSLKQYTYGESLVGNDRFEGYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAP 545
            :|:::|..||...|:...  .|.|||:||||..||...::..||..|:|:||.||:||:.|:..
  Fly   419 VVTTILSNPYCMRKESAI--PLSGNDQFEGYAVDLIHEISKSLGFNYKIQLVPDGSYGSLNKLT- 480

  Fly   546 GGWDGMVGELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPLS 610
            |.|:||:.||:.:.||:||:.:|||.|||:.:||:.|||.||:||:.:||:||.|.:||||:|||
  Fly   481 GEWNGMIRELLEQRADLAIADLTITFEREQAVDFTTPFMNLGVSILYRKPIKQPPNLFSFLSPLS 545

  Fly   611 QEIWISVILSYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPP 675
            .::||.:..:|:|||.:|:.:.:|.||||.                       :...||...| .
  Fly   546 LDVWIYMATAYLGVSVLLFILAKFTPYEWP-----------------------AYTDAHGEKV-E 586

  Fly   676 NEFTMLNSFWYSLAAFMQQGCDITPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPI 740
            ::||:||..|:::.:.||||||..|.:::.|:.|.:|||||:|:|||||||||||||||||.:||
  Fly   587 SQFTLLNCMWFAIGSLMQQGCDFLPKALSTRMVAGIWWFFTLIMISSYTANLAAFLTVERMDSPI 651

  Fly   741 KTPEDLTMQTDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYMNANQHHSVHTYD--EGIRRVRQSK 803
            ::.|||..||.:.||.|..|||..|||.|:|..:.:||.:|. :...||.|..  ||:.||.:.|
  Fly   652 ESAEDLAKQTRIKYGALKGGSTAAFFRDSKISTYQRMWSFME-SARPSVFTASNGEGVERVAKGK 715

  Fly   804 GKYALLVESPKNEYVNARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRI 868
            |.||.|:||...|||..| .|:..:||..:|||.:|:|||..||.|..:|..:|.|:|.|:|..:
  Fly   716 GSYAFLMESTSIEYVTER-NCELTQVGGMLDTKSYGIATPPNSPYRTAINSVILKLQEEGKLHIL 779

  Fly   869 RNKWWFDKT---ECNLD--QETSTPNELSLSNVAGIYYILIGGLLLAVIVAIMEFFCRNK 923
            :.|||.:|.   :|.::  :.:|..|||.|:||.|::.:|:||:.:|.::|:.||..:::
  Fly   780 KTKWWKEKRGGGKCRVETSKSSSAANELGLANVGGVFVVLMGGMGVACVIAVCEFVWKSR 839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375	93/417 (22%)
		ANF_receptor	53..434	CDD:279440	88/386 (23%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	179/406 (44%)
		Lig_chan	612..907	CDD:278489	125/301 (42%)
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..397	CDD:107377	95/422 (23%)
		ANF_receptor	42..378	CDD:279440	89/388 (23%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:304360	177/398 (44%)
		Lig_chan	547..823	CDD:278489	125/301 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	169	1.000	Inparanoid score	I1556
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7871
SonicParanoid	0	0.000	Not matched by this tool.
	9	8.890