Protein Alignment GluRIA and Ir85a

DIOPT Version :10

• Sequence 1: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: NP_649833.1
• Gene: Ir85a / 41052
• FlyBaseID: FBgn0037630
• Length: 605
• Species: Drosophila melanogaster
• Alignment Length: 754
• Identity: 120/754 - (15%)
• Similarity: 247/754 - (32%)
• Gaps: 255/754 - (33%)

  Fly   258 HYLLSGLVM------DNHWPSDVVEFGAINITGFRIVDSNR-RAVRDFHDSRKRLEPSGQSQSQ- 314
            |.||..:::      :||.|.|:.:...:.:...:|:...| :.:..:.:::...|.:||...:
  Fly     8 HILLLAILVNLAGTRENHIPLDLKKSSIVMVKMSQILCKARIKVLFVYFENQTSHEHTGQILKEV 72

  Fly   315 ------NAGGPNSLPAISAQAALMYDAVFVLVEAFN----RILRKKPDQFRSNHLQRRSHGGSSS 369
                  |...|  |.|:.....||| .|.:......    .::|||      :..:.|||
  Fly    73 TKCDISNQNTP--LEAVKDDGILMY-MVMITTNISQPLELSLIRKK------SAAKHRSH----- 123

  Fly   370 SSATGTNESSALL--DCNT-SKGWV-TPWEQGEKISRVLRKVEIDGLSGEIRFDEDGRRINYTLH 430
                     ..||  |.:| |..|: ..:.|..||                          :.|:
  Fly   124 ---------VFLLVRDADTVSDAWMRASFRQFWKI--------------------------WLLN 153

  Fly   431 VVEMSVNSTLQQVAEWRDDAGLLPLHSH-----NYASSSRSASASTGDYDRNHTYIVSSLLEEPY 490
            :|          :..|||  |.|..:.:     ||.....:........::.....:.::..:|
  Fly   154 IV----------ILYWRD--GRLNAYRYNPFMDNYLIPVDNKPNEVPTLEQLFPKTIPNMQRKP- 205

  Fly   491 LSLKQYTYGE----------SLVGNDRFEGYCKDLADMLAAQLG--IKYEIRLVQDGNYGAENQY 543
              |:...|.:          :::|.|          .:|||.:.  :...:.:.:..:|...|..
  Fly   206 --LRMCIYKDDVRAIFWRQGTILGTD----------GLLAAYVAERLNATMMITRPHSYNNHNLS 258

  Fly   544 APGGWDGMVGELIRKEADIAISAM-----TITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVF 603
            :    |....|:.::..|:|::..     |...:.|..:..::.    .:.:::.| .|..|..:
  Fly   259 S----DICFLEVAKEYVDVAMNIRFLVPDTFRKQAESTVSHTRD----DLCVIVPK-AKTAPTFW 314

  Fly   604 SFLNPLSQEIWISVILSYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQQPPGIIGGATLSEPQA 668
            :........:|..:::|.:..:...|.:               .....:.|..:..|| |:.|..
  Fly   315 NIFRSFGSLVWALILVSVLVANVFCYIL---------------KSEVGRVPMQLFAGA-LTMPMT 363

  Fly   669 HVPPVPPNEFTMLNSFWYSLAAFMQQGCDITPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTV 733
            .:||.            :|:..|:                 ..|.:|.:::.|::..||.:.:..
  Fly   364 QIPPN------------HSIRLFL-----------------IFWLYFGLLICSAFKGNLTSMMVF 399

  Fly   734 ERMVAPIKTPEDLTMQTDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYMNANQHHSV--HTYDEGI 796
            :..:            .|:|....|..|.:....|.:         ::...||...  |.::..|
  Fly   400 QPYL------------PDINQLGALARSHYHIIIRPR---------HVKHIQHFLTLGHKHESRI 443

  Fly   797 RR-------------VRQSKGKYALLVESPKNEY------VNARPPCDTMKVGRNIDTKGFGV-- 840
            |.             :|.:..::|.|     .:|      ||:|.   .|.:||.:    |.:
  Fly   444 REQMLEVSDTQMYEMMRNNDIRFAYL-----EKYHIARFQVNSRV---HMHLGRPL----FHLMN 496

  Fly   841 ----------ATPIGSPLRKRLNEAVLTLKENGELLRIRNKWW-------FDKTECN-LDQETST 887
                      ..|.|||....|:..:.:..|.|     ..::|       |.|:... :::...:
  Fly   497 SCLVPFHAVYIVPYGSPYLGFLDSLIRSSHEFG-----FERYWDRIMNSAFIKSGVKVVNRRRGS 556

  Fly   888 PNE----LSLSNVAGIYYILIGGLLLAVIVAIMEFFCRN 922
            .|:    |.|.:...::.:.:.|:.:|.||...|....|
  Fly   557 GNDEPVVLKLQHFHAVFALWLVGIGMACIVLAWEHLTHN 595

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..456	CDD:380603	42/219 (19%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	67/458 (15%)
		Lig_chan	610..906	CDD:459656	51/340 (15%)
Ir85a	NP_649833.1	None