Protein Alignment GluRIA and gria4a

DIOPT Version :10

• Sequence 1: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: NP_999971.1
• Gene: gria4a / 407735
• ZFINID: ZDB-GENE-020125-7
• Length: 898
• Species: Danio rerio
• Alignment Length: 930
• Identity: 385/930 - (41%)
• Similarity: 535/930 - (57%)
• Gaps: 112/930 - (12%)

  Fly    40 IPLGAIFEQGTDDVQSAFKYAMLNHNL--NVSSRRFELQAYVDVINTADAFKLSRLICNQFSRGV 102
            :.:|.:|.:.||...:||:.|:..||.  |.:...|.|..:||.|.||::|.::...|:|:||||
Zfish    22 VQIGGLFIRNTDQEYTAFRLAIFLHNTSPNATEAPFNLVPHVDNIETANSFAVTNAFCSQYSRGV 86

  Fly   103 YSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLAPSSGLLDFAISMRPDYHQAIIDTIQYYG 167
            :::.|.....|..||.|:.:...:..|||.|      |:.|...|.:.:||....|::..:.:|.
Zfish    87 FAIFGLYDKRSVHTLTSFCSALHISLVTPSF------PAEGETQFVLQLRPSIRGALLSLLDHYD 145

  Fly   168 WQSIIYLYDSHDGLLRLQQIYQELKPGNETFRVQMVKRIANVTMAIEFLHTLEDLGRFSKKRIVL 232
            |...::|||:..|...||.|.:  |.|...::|..: .:.|...| .:...||||.|..:|:.|:
Zfish   146 WSRFVFLYDTDRGYAVLQAIME--KAGQNGWQVSAI-CVENFNDA-SYRRLLEDLDRRQEKKFVI 206

  Fly   233 DCPAEMAKEIIVQHVRDIKLGR--RTYHYLLSGLVMDNHWPSDV----VEFGAINITGFRIVDSN 291
            |..||..:.|:.|.|   .:|:  :.|||:::.|..     .|:    ...|..|:|||::||.:
Zfish   207 DLEAERLQNILEQIV---SVGKHVKGYHYIVANLGF-----KDISLERFMHGGANVTGFQLVDFS 263

  Fly   292 RRAVRDFHDSRKRLEPSGQSQSQNAGGPNSLPAISAQAALMYDAVFVLVEAFNRILRKKPDQFRS 356
            :..|      .|.::...:...:...|..|.|..:  ::|.||.|.|:.|||..:.|:|.|
Zfish   264 KPMV------IKLMQRWNKLDQREYPGSESPPRYT--SSLTYDGVLVMAEAFRNLRRQKID---- 316

  Fly   357 NHLQRRSHGGSSSSSATGTNESSALLDCNTSKGWVTPWEQGEKISRVLRKVEIDGLSGEIRFDED 421
              :.||.:.|                ||..:.  ..||.||..:.|.|::|.|.||:|.|:||..
Zfish   317 --ISRRGNAG----------------DCLANP--AAPWNQGIDMERTLKQVRIQGLTGNIQFDHY 361

  Fly   422 GRRINYTLHVVEMSVNSTLQQVAEWRDDAGLLPLHSHNYASSSRSASASTGDYDRNHTYIVSSLL 486
            |||:|||:.|.|:..|.. :::..| :|...|.|..:..:..:.||.       .|.|.||::::
Zfish   362 GRRVNYTMDVFELKSNGP-RKIGYW-NDLDKLVLVQNELSMGNDSAM-------ENRTVIVTTIM 417

  Fly   487 EEPYLSLKQYTYGESLVGNDRFEGYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAPGGWDGM 551
            |.||:.||:  ..|...||::|||||.|||..:|..:||||:|.:|.||.|||.:.... .|:||
Zfish   418 EGPYVMLKK--NWEMYEGNEQFEGYCVDLASEVAKHIGIKYKISIVLDGKYGARDPETK-IWNGM 479

  Fly   552 VGELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPLSQEIWIS 616
            ||||:..:|:||::.:.||..||.|||||||||:||||||||||.|..|||||||:||:.|||:.
Zfish   480 VGELVYGKAEIAVAPLAITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMC 544

  Fly   617 VILSYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPNEFTML 681
            ::.:|:|||.||:.|:||.||||. ...|:..|..  ||.               ..|||||.:.
Zfish   545 IVFAYIGVSVVLFLVSRFSPYEWH-TEEPEEGSDG--PPS---------------DQPPNEFGIF 591

  Fly   682 NSFWYSLAAFMQQGCDITPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKTPEDL 746
            ||.|:||.||||||||.||.|::|||...||||||:|:||||||||||||||||||:||::.|||
Zfish   592 NSLWFSLGAFMQQGCDFTPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDL 656

  Fly   747 TMQTDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYM-NANQHHSVHTYDEGIRRVRQSKGKYALLV 810
            ..||::.||||..|||.||||||:|.::.|||.|| :|.......|..||:.|||:||||||.|:
Zfish   657 AKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPTVFTKTTAEGVARVRKSKGKYAFLL 721

  Fly   811 ESPKNEYVNARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFD 875
            ||..|||...|.||||||||.|:|:||:|||||.||.|...:|.|||.|.|.|.|.:::||||:|
Zfish   722 ESTMNEYTEQRKPCDTMKVGGNLDSKGYGVATPKGSQLGTPVNLAVLKLSEAGVLDKLKNKWWYD 786

  Fly   876 KTEC---NLDQETSTPNELSLSNVAGIYYILIGGLLLAVIVAIMEFFC----------------- 920
            |.||   :...:..:...||||||||::|||:|||.||::||::| ||
Zfish   787 KGECGPKDSGSKDKSSQALSLSNVAGVFYILVGGLGLAMLVALVE-FCYKSRAEAKKLKLTFSEA 850

  Fly   921 -RNKTPQLKSPGSNGSAGGV 939
             |||. :|...||.|..|.|
Zfish   851 MRNKA-RLSITGSLGENGRV 869

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..456	CDD:380603	126/422 (30%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	224/402 (56%)
		Lig_chan	610..906	CDD:459656	162/299 (54%)
gria4a	NP_999971.1	PBP1_iGluR_AMPA_GluR4	23..395	CDD:380611	127/423 (30%)
		PBP2_iGluR_AMPA_GluR4	408..790	CDD:270445	224/402 (56%)