DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIA and gria4a

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	NP_999971.1	Gene:	gria4a / 407735	ZFINID:	ZDB-GENE-020125-7	Length:	898	Species:	Danio rerio

Alignment Length:	930	Identity:	385/930 - (41%)
Similarity:	535/930 - (57%)	Gaps:	112/930 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 IPLGAIFEQGTDDVQSAFKYAMLNHNL--NVSSRRFELQAYVDVINTADAFKLSRLICNQFSRGV 102
            :.:|.:|.:.||...:||:.|:..||.  |.:...|.|..:||.|.||::|.::...|:|:||||
Zfish    22 VQIGGLFIRNTDQEYTAFRLAIFLHNTSPNATEAPFNLVPHVDNIETANSFAVTNAFCSQYSRGV 86

  Fly   103 YSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLAPSSGLLDFAISMRPDYHQAIIDTIQYYG 167
            :::.|.....|..||.|:.:...:..|||.|      |:.|...|.:.:||....|::..:.:|.
Zfish    87 FAIFGLYDKRSVHTLTSFCSALHISLVTPSF------PAEGETQFVLQLRPSIRGALLSLLDHYD 145

  Fly   168 WQSIIYLYDSHDGLLRLQQIYQELKPGNETFRVQMVKRIANVTMAIEFLHTLEDLGRFSKKRIVL 232
            |...::|||:..|...||.|.:  |.|...::|..: .:.|...| .:...||||.|..:|:.|:
Zfish   146 WSRFVFLYDTDRGYAVLQAIME--KAGQNGWQVSAI-CVENFNDA-SYRRLLEDLDRRQEKKFVI 206

  Fly   233 DCPAEMAKEIIVQHVRDIKLGR--RTYHYLLSGLVMDNHWPSDV----VEFGAINITGFRIVDSN 291
            |..||..:.|:.|.|   .:|:  :.|||:::.|..     .|:    ...|..|:|||::||.:
Zfish   207 DLEAERLQNILEQIV---SVGKHVKGYHYIVANLGF-----KDISLERFMHGGANVTGFQLVDFS 263

  Fly   292 RRAVRDFHDSRKRLEPSGQSQSQNAGGPNSLPAISAQAALMYDAVFVLVEAFNRILRKKPDQFRS 356
            :..|      .|.::...:...:...|..|.|..:  ::|.||.|.|:.|||..:.|:|.|
Zfish   264 KPMV------IKLMQRWNKLDQREYPGSESPPRYT--SSLTYDGVLVMAEAFRNLRRQKID---- 316

  Fly   357 NHLQRRSHGGSSSSSATGTNESSALLDCNTSKGWVTPWEQGEKISRVLRKVEIDGLSGEIRFDED 421
              :.||.:.|                ||..:.  ..||.||..:.|.|::|.|.||:|.|:||..
Zfish   317 --ISRRGNAG----------------DCLANP--AAPWNQGIDMERTLKQVRIQGLTGNIQFDHY 361

  Fly   422 GRRINYTLHVVEMSVNSTLQQVAEWRDDAGLLPLHSHNYASSSRSASASTGDYDRNHTYIVSSLL 486
            |||:|||:.|.|:..|.. :::..| :|...|.|..:..:..:.||.       .|.|.||::::
Zfish   362 GRRVNYTMDVFELKSNGP-RKIGYW-NDLDKLVLVQNELSMGNDSAM-------ENRTVIVTTIM 417

  Fly   487 EEPYLSLKQYTYGESLVGNDRFEGYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAPGGWDGM 551
            |.||:.||:  ..|...||::|||||.|||..:|..:||||:|.:|.||.|||.:.... .|:||
Zfish   418 EGPYVMLKK--NWEMYEGNEQFEGYCVDLASEVAKHIGIKYKISIVLDGKYGARDPETK-IWNGM 479

  Fly   552 VGELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPLSQEIWIS 616
            ||||:..:|:||::.:.||..||.|||||||||:||||||||||.|..|||||||:||:.|||:.
Zfish   480 VGELVYGKAEIAVAPLAITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMC 544

  Fly   617 VILSYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPNEFTML 681
            ::.:|:|||.||:.|:||.||||. ...|:..|..  ||.               ..|||||.:.
Zfish   545 IVFAYIGVSVVLFLVSRFSPYEWH-TEEPEEGSDG--PPS---------------DQPPNEFGIF 591

  Fly   682 NSFWYSLAAFMQQGCDITPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKTPEDL 746
            ||.|:||.||||||||.||.|::|||...||||||:|:||||||||||||||||||:||::.|||
Zfish   592 NSLWFSLGAFMQQGCDFTPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDL 656

  Fly   747 TMQTDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYM-NANQHHSVHTYDEGIRRVRQSKGKYALLV 810
            ..||::.||||..|||.||||||:|.::.|||.|| :|.......|..||:.|||:||||||.|:
Zfish   657 AKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPTVFTKTTAEGVARVRKSKGKYAFLL 721

  Fly   811 ESPKNEYVNARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFD 875
            ||..|||...|.||||||||.|:|:||:|||||.||.|...:|.|||.|.|.|.|.:::||||:|
Zfish   722 ESTMNEYTEQRKPCDTMKVGGNLDSKGYGVATPKGSQLGTPVNLAVLKLSEAGVLDKLKNKWWYD 786

  Fly   876 KTEC---NLDQETSTPNELSLSNVAGIYYILIGGLLLAVIVAIMEFFC----------------- 920
            |.||   :...:..:...||||||||::|||:|||.||::||::| ||
Zfish   787 KGECGPKDSGSKDKSSQALSLSNVAGVFYILVGGLGLAMLVALVE-FCYKSRAEAKKLKLTFSEA 850

  Fly   921 -RNKTPQLKSPGSNGSAGGV 939
             |||. :|...||.|..|.|
Zfish   851 MRNKA-RLSITGSLGENGRV 869

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375	125/419 (30%)
		ANF_receptor	53..434	CDD:279440	117/388 (30%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	224/402 (56%)
		Lig_chan	612..907	CDD:278489	163/298 (55%)
gria4a	NP_999971.1	PBP1_iGluR_AMPA_GluR4	23..393	CDD:107383	126/421 (30%)
		ANF_receptor	34..375	CDD:279440	118/390 (30%)
		PBP2_iGluR_AMPA_GluR4	408..790	CDD:270445	224/402 (56%)
		Lig_chan	540..821	CDD:278489	163/298 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590925
Domainoid	1	1.000	371	1.000	Domainoid score	I851
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	698	1.000	Inparanoid score	I657
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D89427at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm6377
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.910