DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIA and gria1b

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	NP_991293.1	Gene:	gria1b / 403044	ZFINID:	ZDB-GENE-020125-2	Length:	917	Species:	Danio rerio

Alignment Length:	987	Identity:	380/987 - (38%)
Similarity:	550/987 - (55%)	Gaps:	143/987 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 SLTEKIPLGAIFEQGTDDVQ-SAFKYAMLNHNLNVSSRRFELQAYVDVINTADAFKLSRLICNQF 98
            |....|.:|.:|.  ||..: ..|::|:..|| :|.    :|...||:::|..:|.::...|:||
Zfish    20 SFPSNINIGGLFP--TDSHEYDVFRFALSQHN-DVP----KLVPQVDMVDTGSSFAMTYAFCSQF 77

  Fly    99 SRGVYSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLAPSSGLLD----FAISMRPDYHQAI 159
            |:|||:::|.....:.:.|.|:.....:.||||.||          :|    |.|.:||:...|:
Zfish    78 SKGVYAIIGLYDRKTMNMLMSFCGALHVCFVTPSFP----------IDTNNQFVIQLRPELQDAL 132

  Fly   160 IDTIQYYGWQSIIYLYDSHDGLLRLQQIYQELKPGNETFRVQMVKRIANVTMAIEFLHTLEDLGR 224
            |..:::|.|...:|:|.|..||..||:|..  ....:|::|..: ....:|.| .||..::||..
Zfish   133 IALVEHYKWNKFVYMYSSDSGLTVLQKILD--TAAEKTWQVTSI-NFDTLTEA-AFLKAIQDLDN 193

  Fly   225 FSKKRIVLDCPAEMAKEIIVQHVRDIKLGRRTYHYLLSGL-VMDNHWPSDVVEF--GAINITGFR 286
            ..:.:|:|||..|....|: ..:...|...:.|||:|:.| .:|    .::.||  |..|:|||:
Zfish   194 KKEFKIILDCELERLNSIL-NLIAAQKKNLKNYHYILANLGFLD----LNLTEFRKGGANVTGFQ 253

  Fly   287 IVDSNRRAV------------RDFHDSRKRLEPSGQSQSQNAGGPNSLPAISAQAALMYDAVFVL 339
            :::.....|            :|....::||:.:|                    ||.||.|.|:
Zfish   254 LMNYTNPTVSRTIQDWLEFDSKDLKSPKRRLKYTG--------------------ALTYDGVTVM 298

  Fly   340 VEAFNRILRKKPDQFRSNHLQRRSHGGSSSSSATGTNESSALLDCNTSKGWVTPWEQGEKISRVL 404
            ..||..:.:::.|      :.||.:.|...::..                  .||.||..|.|.|
Zfish   299 ATAFQNLRKQRID------ISRRGNAGECLANPP------------------APWGQGIDIQRAL 339

  Fly   405 RKVEIDGLSGEIRFDEDGRRINYTLHVVEMSVNSTLQQVAEWRDDAGLLPLHSHNYASSSRSASA 469
            ::|:.:||:|.::|::.|.|.|:|:.|:|...:.. ::|..|                :.|....
Zfish   340 QQVQFEGLTGHVQFNDKGHRTNFTVSVMEFGPSGP-KKVGYW----------------NQREKYV 387

  Fly   470 STGDYD---------RNHTYIVSSLLEEPYLSLKQYTYGESLVGNDRFEGYCKDLADMLAAQLGI 525
            ||..|.         :|.||:|:::||.||:.||:  ..|.|||||::||||.:||..:|..:|.
Zfish   388 STATYSNMLNETFGLQNRTYVVTTILEAPYVMLKK--NHEQLVGNDKYEGYCVELAAEIAKHVGY 450

  Fly   526 KYEIRLVQDGNYGAENQYAPGGWDGMVGELIRKEADIAISAMTITAERERVIDFSKPFMTLGISI 590
            .|.:.||.||.|||.:.... .|:||||||:..:||:|::.:|||..||.|||||||||:|||||
Zfish   451 SYRLELVGDGKYGARDAETM-MWNGMVGELVYGKADVAVAPLTITLVREEVIDFSKPFMSLGISI 514

  Fly   591 MIKKPVKQTPGVFSFLNPLSQEIWISVILSYVGVSFVLYFVTRFPPYEWRIVRRPQ-ADSTAQ-Q 653
            |||||.|..|||||||:||:.|||:.::.:|:|||.||:.|:||.||||......: ||...| |
Zfish   515 MIKKPTKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHADDEEETADQQNQNQ 579

  Fly   654 PPGIIGGATLSEPQ------AHVPPVPPNEFTMLNSFWYSLAAFMQQGCDITPPSIAGRIAAAVW 712
            ||......:.::.|      ....|...|||.:.||.|:||.|||||||||:|.|::|||...||
Zfish   580 PPSPEPNQSPNQSQNQREEKQEKQPEHTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVW 644

  Fly   713 WFFTIILISSYTANLAAFLTVERMVAPIKTPEDLTMQTDVNYGTLLYGSTWEFFRRSQIGLHNKM 777
            ||||:|:||||||||||||||||||:||::.|||..||::.||||..|||.||||||:|.:..||
Zfish   645 WFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDGGSTKEFFRRSKIAVFEKM 709

  Fly   778 WEYM-NANQHHSVHTYDEGIRRVRQSKGKYALLVESPKNEYVNARPPCDTMKVGRNIDTKGFGVA 841
            |.|| :|.....|.|.|||:.|||:||||||.|:||..|||:..|.||||||||.|:|:||:|||
Zfish   710 WSYMKSAEPTVFVKTTDEGVVRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVA 774

  Fly   842 TPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFDKTECNL---DQETSTPNELSLSNVAGIYYIL 903
            ||.||.||..:|.|||.|.|.|.|.:::||||:||.||..   |.:..| :.||||||||::|||
Zfish   775 TPKGSALRNPVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKT-SALSLSNVAGVFYIL 838

  Fly   904 IGGLLLAVIVAIMEFFCRNK-----------TPQLKSPGSNGSAGGVPGMLASSTYQRDSLSDAI 957
            ||||.||::||::||..:::           ...|.|..:...:||..|.:.:..:.:.:.:...
Zfish   839 IGGLGLAMLVALVEFCYKSRIESRRMKQIIDAAMLSSTLTRMGSGGENGRVMAHDFPKGAQTLPC 903

  Fly   958 MHSQAKLAMQAS 969
            |...|.:.:..:
Zfish   904 MGQAAAMGLSTT 915

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375	112/431 (26%)
		ANF_receptor	53..434	CDD:279440	105/400 (26%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	230/410 (56%)
		Lig_chan	612..907	CDD:278489	171/306 (56%)
gria1b	NP_991293.1	PBP1_iGluR_AMPA_GluR1	26..387	CDD:107385	113/447 (25%)
		ANF_receptor	41..368	CDD:279440	105/394 (27%)
		PBP2_iGluR_AMPA_GluR1	404..812	CDD:270447	230/410 (56%)
		Lig_chan	536..842	CDD:278489	171/306 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590917
Domainoid	1	1.000	371	1.000	Domainoid score	I851
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	698	1.000	Inparanoid score	I657
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D89427at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm6377
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.770