DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GluRIA and Ir68b

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	NP_648548.1	Gene:	Ir68b / 39378	FlyBaseID:	FBgn0036250	Length:	635	Species:	Drosophila melanogaster

Alignment Length:	440	Identity:	80/440 - (18%)
Similarity:	148/440 - (33%)	Gaps:	106/440 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   530 RLVQDGNYGAENQYAPGGWDGMVGELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKK 594
            |.:.:|||           .|:|.:::......|.::..:.......::...|:....:.:::..
  Fly   247 RCLPNGNY-----------TGVVSDIVGGHTHFAPNSRFVLDCIWPAVEVLYPYTRRNLHLVVPA 300

  Fly   595 PVKQTPGVFSFLNPLSQEIWISVILSYVGVSFVLYFVTRFPPYEWRIVRRP--QADSTAQQPPGI 657
            ...| |....|:....:.:|..::::.:.|..|.:.:.|.   :.||.||.  |..:|..:...:
  Fly   301 SAIQ-PEYLIFVRVFRRTVWYLLLVTLLVVVLVFWVMQRL---QRRIPRRGVIQFQATWYEILEM 361

  Fly   658 IGGATLSEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGCDITPPSIAGRIAAAVWWFFTIILISS 722
            .|...:.||...:     :.|:.:.:|                  :.|      |..|:.:|.:.
  Fly   362 FGKTHVGEPAGRL-----SSFSSMRTF------------------LMG------WILFSYVLSTI 397

  Fly   723 YTANLAAFLTVERMVAPIKTPEDLTMQTDVN-YG-TLLYGSTWEFFRRSQIGLHNKMWEYMNANQ 785
            |.|.|.:..........:...:|| :..||: |. |.:|.:........|.||    .|..:...
  Fly   398 YFAKLESGFVRPSYEEQVDRVDDL-VHLDVHIYAVTTMYDAVRSALTEHQYGL----LENRSRQL 457

  Fly   786 HHSVHT--YDEGIRR--------VRQSKGKYALLV----ESPKNEYVNARPPCDTMKVGRNIDTK 836
            ...:.|  |...:||        :|....:..|.:    ::.:..|..||....:|
  Fly   458 PLGIATSYYQPVVRRRDRRAAFIMRDFHARDFLAITYDSQAERPAYHIAREYLRSM--------- 513

  Fly   837 GFGVAT---PIGSPLRKRLNEAVLTLKENGELLRIRNKWWFDKTECNLDQE------------TS 886
               :.|   |.|||...||........|:|.....|......:...:.|.|            .|
  Fly   514 ---ICTYILPRGSPFLHRLESLYSGFLEHGFFEHWRQMDLITRVGASPDAEEFLEDLGDQTDTDS 575

  Fly   887 TPNELSLSN---------VAGIYYIL---IGGLLLAVIVAIMEFFCRNKT 924
            ..|||::.|         :.|.:|:.   ||...|...|....:|.|.:|
  Fly   576 GSNELAIRNKKVVLTLDILQGAFYLWSVGIGISCLGFAVEHAHWFWRRQT 625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375
		ANF_receptor	53..434	CDD:279440
		PBP2_iGluR_AMPA	477..879	CDD:270433	64/369 (17%)
		Lig_chan	612..907	CDD:278489	64/339 (19%)
Ir68b	NP_648548.1	Lig_chan	333..607	CDD:278489	60/322 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462577
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840