DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GluRIA and Ir68a

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	NP_648455.2	Gene:	Ir68a / 39269	FlyBaseID:	FBgn0036150	Length:	704	Species:	Drosophila melanogaster

Alignment Length:	485	Identity:	96/485 - (19%)
Similarity:	173/485 - (35%)	Gaps:	137/485 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   508 FEGYCKDLADMLAAQLGIK---YEIRLVQDGNY-----GAENQYAPGGWDG-----------MVG 553
            |:|...::.:.|...|..|   |:....::.::     ||...|..|..||           :|.
  Fly   244 FQGVEVEIMNALGKALNFKPVYYKPNQTENMDWTELDGGASVAYGSGNPDGYAQNGTHIDSMLVD 308

  Fly   554 ELIRKEADIAISAMTITAERERVIDFSKP-------FMTLGISIMIKKPVKQTPGVF-SFLNPLS 610
            |:....|..||..:.:.....::::.|.|       |:|         |...|...: :|:.|.|
  Fly   309 EVAAHSARFAIGDLHLFQVYLKLVELSAPHNFECLTFLT---------PESSTDNSWQTFILPFS 364

  Fly   611 QEIWISVILSYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQQPPGIIGGATLSE------PQAH 669
            ..:|:.|:||...|..|.|.::..                    ..||.|...||      |..:
  Fly   365 AGMWVGVLLSLFVVGTVFYAISFL--------------------NAIINGNVSSEFFRCLRPNRN 409

  Fly   670 VPPVPPNEFTMLNSFWYSLAAFMQQGCDITPPSIAG---------------------------RI 707
            | |:.|..:..: ||..:::.:.....|..|..:..                           |:
  Fly   410 V-PMDPKIYRRI-SFRIAISRYRSSKGDRMPRDLFDGYTNCILLTYSMLLYVALPRMPRNWPLRV 472

  Fly   708 AAAVWWFFTIILISSYTANLAAFLTVERMVAPIKTPEDLTMQTDVNYGTLLYGST--WEFFRRSQ 770
            ....:|.:.|:|:::|.|:..|.|........|.|.||| :::.:...|   |:|  .:||..:.
  Fly   473 LTGWYWIYCILLVATYRASFTAILANPAARVTIDTLEDL-LRSHIPPST---GATENRQFFLEAN 533

  Fly   771 IGLHNKMWEYMNANQHHSVHTYDEGIRRVRQSKGKYALLVESPKNEYVNARPPCDTMKVGRNIDT 835
            ..:..|:.|.|      .|..|.:.:.. |.:||:.|..    .||:.        ::..|..|.
  Fly   534 DEVARKVGEKM------EVFGYSDDLTS-RIAKGQCAYY----DNEFY--------LRYLRVADE 579

  Fly   836 KGFG--------------VATPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFDKTECNLDQETS 886
            .|..              :|....|.|:.|::.::..|.|.|.:.    ||..|..| :|..|..
  Fly   580 SGSALHIMKECVLYMPVVLAMEKNSALKPRVDASIQHLAEGGLIA----KWLKDAIE-HLPAEAL 639

  Fly   887 TPNELSLSNVAGIYYILIGGLLLAVIVAIM 916
            ...| :|.|:...:...: .||:..:::::
  Fly   640 AQQE-ALMNIQKFWSSFV-ALLIGYVISML 667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375
		ANF_receptor	53..434	CDD:279440
		PBP2_iGluR_AMPA	477..879	CDD:270433	88/446 (20%)
		Lig_chan	612..907	CDD:278489	68/343 (20%)
Ir68a	NP_648455.2	Lig_chan	429..661	CDD:278489	52/261 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462517
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740